Until now, no comprehensive handbook on industrial biocatalysis has been available. Soliciting chapters on virtually every aspect of biocatalysis from international experts most actively researching the field, the Handbook of Industrial Biocatalysis fills this need. The handbook is divided into three sections based on types of substrates. T
Substantially revising and updating the classic reference in the field, this handbook offers a valuable overview and myriad details on current chemical processes, products, and practices. No other source offers as much data on the chemistry, engineering, economics, and infrastructure of the industry. The Handbook serves a spectrum of individuals, from those who are directly involved in the chemical industry to others in related industries and activities. It provides not only the underlying science and technology for important industry sectors, but also broad coverage of critical supporting topics. Industrial processes and products can be much enhanced through observing the tenets and applying the methodologies found in chapters on Green Engineering and Chemistry (specifically, biomass conversion), Practical Catalysis, and Environmental Measurements; as well as expanded treatment of Safety, chemistry plant security, and Emergency Preparedness. Understanding these factors allows them to be part of the total process and helps achieve optimum results in, for example, process development, review, and modification. Important topics in the energy field, namely nuclear, coal, natural gas, and petroleum, are covered in individual chapters. Other new chapters include energy conversion, energy storage, emerging nanoscience and technology. Updated sections include more material on biomass conversion, as well as three chapters covering biotechnology topics, namely, Industrial Biotechnology, Industrial Enzymes, and Industrial Production of Therapeutic Proteins.
The aim of this book is to present in a single volume an up-to-date account of the chemistry and chemical engineering which underlie the major areas of the chemical process industry. This most recent edition includes several new chapters which comprise important threads in the industry's total fabric. These new chapters cover waste minimization, safety considerations in chemical plant design and operation, emergency response planning, and statistical applications in quality control and experimental planning. Together with the chapters on chemical industry economics and wastewater treatment~ they provide a unifying base on which the reader can most effectively apply the information provided in the chapters which describe the various areas of the chemical process industries. The ninth edition of this established reference work contains the contributions of some fifty experts from industry, government, and academe. I have been humbled by the breadth and depth of their knowledge and expertise and by the willingness and enthusiasm with which they shared their knowledge and insights. They have, without exception, been unstinting in their efforts to make their respective chapters as complete and informative as possible within the space available. Errors of omission, duplication, and shortcomings in organization are mine. Grateful acknowledgment is made to the editors of technical journals and publishing houses for permission to reproduce illustrations and other materials and to the many industrial concerns which contributed drawings and photographs. Comments and criticisms by readers will be welcome.
Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts-with
This substantially revised and updated classic reference offers a valuable overview and myriad details on current chemical processes, products, and practices. No other source offers as much data on the chemistry, engineering, economics, and infrastructure of the industry. The two volume Handbook serves a spectrum of individuals, from those who are directly involved in the chemical industry to others in related industries and activities. Industrial processes and products can be much enhanced through observing the tenets and applying the methodologies found in the book’s new chapters.
This widely respected and frequently consulted reference work provides a wealth of information and guidance on industrial chemistry and biotechnology. Industries covered span the spectrum from salt and soda ash to advanced dyes chemistry, the nuclear industry, the rapidly evolving biotechnology industry, and, most recently, electrochemical energy storage devices and fuel cell science and technology. Other topics of surpassing interest to the world at large are covered in chapters on fertilizers and food production, pesticide manufacture and use, and the principles of sustainable chemical practice, referred to as green chemistry. Finally, considerable space and attention in the Handbook are devoted to the subjects of safety and emergency preparedness. It is worth noting that virtually all of the chapters are written by individuals who are embedded in the industries whereof they write so knowledgeably.
Describing all topics of white biotechnology admitted to the 7th EU Frame Programme and new industrial production processes aiming towards the Kyoto objectives, this comprehensive overview covers the technology, applications, economic potential and implications for society. Directed at readers with a general interest in a specific technology, this is equally suitable as an introductory handbook to a wide range of industries, including chemicals, biotechnology and pharmaceuticals, food and feed, paper and pulp, personal care, energy and agriculture.
Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.
This book provides an actual overview of the structure, function, and application of carbohydrate-modifying biocatalysts. Carbohydrates have been disregarded for a long time by the scientific community, mainly due to their complex structure. Meanwhile, the situation changed with increasing knowledge about the key role carbohydrates play in biological processes such as recognition, signal transduction, immune responses, and others. An outcome of research activities in glycoscience is the development of several new pharmaceuticals against serious diseases such as malaria, cancer, and various storage diseases. Furthermore, the employment of carbohydrate-modifying biocatalysts—enzymes as well as microorganisms—will contribute significantly to the development of environmentally friendly processes boosting a shift of the chemical industry from petroleum- to bio-based production of chemicals from renewable resources. The updated content of the second edition of this book has been extended by discussing the current state of the art of using recombinantly expressed carbohydrate-modifying biocatalysts and the synthesis of minicellulosomes in connection with consolidated bioprocessing of lignocellulosic material. Furthermore, a synthetic biology approach for using DAHP-dependent aldolases to catalyze asymmetric aldol reactions is presented.
A diverse team of researchers, technologists, and engineers describe, in simple and practical language, the major current and evolving technologies for improving the biocatalytic capabilities of mammalian, microbial, and plant cells. The authors present state-of-the-art techniques, proven methods, and strategies for industrial screening, cultivation, and scale-up of these cells, and describe their biotech and industrial uses. Special emphasis is given to the solving critical issues encountered during the discovery of new drugs, process development, and the manufacture of new and existing compounds. Other topics include recombinant protein expression, bioinformatics, high throughput screening, analytical tools in biotechnology, DNA shuffling, and genomics discovery.