Guidance Document on Acute Oral Toxicity Testing
Guidance Document on Acute Oral Toxicity Testing

Author: Organisation for Economic Co-operation and Development

Publisher:

Published: 2002

Total Pages: 24

ISBN-13:

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This Guidance Document provides information for both the regulated community and regulators to assist with the choice of the most appropriate Guideline to enable particular data requirements to be met while reducing the number of animals used and animal suffering.

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on Acute Oral Toxicity Testing
OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on Acute Oral Toxicity Testing

Author: OECD

Publisher: OECD Publishing

Published: 2002-05-10

Total Pages: 24

ISBN-13: 926407841X

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This Guidance Document provides information for both the regulated community and regulators to assist with the choice of the most appropriate Guideline to enable particular data requirements to be met while reducing the number of animals used and animal suffering.

OECD Series on Testing and Assessment Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests
OECD Series on Testing and Assessment Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests

Author: OECD

Publisher: OECD Publishing

Published: 2017-04-13

Total Pages: 19

ISBN-13: 9264274758

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Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context of this document, acute toxicity studies refer to studies involving a single exposure to a test chemical and include those assessing systemic toxicity as ...

Test No. 223: Avian Acute Oral Toxicity Test
Test No. 223: Avian Acute Oral Toxicity Test

Author: OECD

Publisher: OECD Publishing

Published: 2010-07-23

Total Pages: 25

ISBN-13: 9264090894

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This Test Guideline describes procedures designed to estimate the acute oral toxicity of substances to birds, and it provides three testing options: (1) limit dose test, (2) LD50-slope test, and (3) LD50-only test. The LD50-slope and LD50-only ...

Alternatives to Animal Testing
Alternatives to Animal Testing

Author: Hajime Kojima

Publisher: Springer

Published: 2018-12-27

Total Pages: 130

ISBN-13: 9811324476

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This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.