Glycoimmunology 2
Glycoimmunology 2

Author: John S. Axford

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 267

ISBN-13: 1461553830

DOWNLOAD EBOOK

The Jenner International Glycoimmunology Meetings have charted the rapid devel opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is making and ranged from the basic biochemistry of carbohydrate physiology to therapeutic trials utilizing synthetic sugars designed to block inflammatory responses. The meeting is summarized in considerable detail in this book which will provide the interested scientist and clinician with the essential up-to-date facts within the field of glyco immunology. Acknowledgments Many people have been involved in ensuring the success of the Jenner Glycoimmu nology Meetings but none more so than my secretary Susan Henderson who has borne the brunt of all four meetings and is currently preparing for the 5th.

Essentials of Glycobiology
Essentials of Glycobiology

Author: Ajit Varki

Publisher: CSHL Press

Published: 1999

Total Pages: 694

ISBN-13: 9780879696818

DOWNLOAD EBOOK

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Glycoimmunology
Glycoimmunology

Author: Azita Alavi

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 291

ISBN-13: 1461518857

DOWNLOAD EBOOK

Proceedings of the Third Jenner International Glycoimmunology meeting held in Il Ciocco, Tuscany, Italy, October 11-14, 1994

Glycoimmunology in Xenotransplantation
Glycoimmunology in Xenotransplantation

Author: Cheorl-Ho Kim

Publisher: Springer Nature

Published: 2024

Total Pages: 378

ISBN-13: 981997691X

DOWNLOAD EBOOK

This book describes general glycobiology in emphasizing the structures, biosynthesis, glycosylation and distribution of the glycans and xenogenic glycoantigens in eukaryotic cells of mammals including mouse, swine, chimpanzee and human. In the middle, I have focused on topics in xenotransplantation glycobiology and expand descriptions of allogenic and xenoantigenic transplantation to open the dawn in insights into the origin of life. One of the biological diversity, named species diversity, is a phenomenon environmentally adapted from the evolutionary process for long period. The distinct structures of glycans discriminate each organism and are the essential molecular basis of the discrimination and difference between the organisms, giving an incompatibility between the different species. Diversity and variations in carbohydrate chain structures between family, species, kingdoms and domains mark the global pattern and signs of immune self- and non-self recognition. In human, diversity in ABH blood group antigens is observed in human family and this type pattern distinguishes individuals from a pan-family to non-dividable unit of the family. Blood transfusion and organ transplantation are impossible even in the allogenic cross between humans if carbohydrates are ignored. This explains how and how human beings are a lonely existence. ABH-related antibodies induce hemolysis or hyperacute or allograft rejection due to incompatible graft property even between the same species. The incompatibility is an immunologic rejection when the recipient host receives the tissues or organs from the different species of donors, as well-known in pig-to-human xenotransplantation. The immunologic incompatibility between the donor pigs and the recipient human are based on the evolutionary distance between pigs and humans. This distance allows a xenograft rejection between the 2 mammals. Modification or deletion of the specific gene locus for immune rejection on genome of donor animals disrupts the immunological recognition ligands of the donor organs, consequently preventing the immune rejection of the human recipient and xenograft rejection. This book helps undergraduate and graduate students, researcher and professors who are involved in the glycobiology and xenoantigenic biology with recent advances in the xenotransplantation basic and clinic.

Protein Glycosylation
Protein Glycosylation

Author: Roslyn M. Bill

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 517

ISBN-13: 1461549396

DOWNLOAD EBOOK

Protein Glycosylation provides clear, up-to-date, and integrated coverage of key topics in this field. Particular emphasis is placed on the biosynthetic pathways that result in a wide variety of identified protein-bound oligosaccharides. Protein Glycosylation begins with an overview of the chemical structures of mono- and oligosaccharides, to provide a scientific basis for the later chapters. The book includes discussions on the purification, function, and enzyme kinetics of selected glycosidases and glycotransferases, as well as a review of the roles of oligosaccharides in glycoprotein function and the in vivo role of glycoproteins themselves. Finally, the in vitro synthesis of glycoproteins is presented, together with future directions in glycobiology. Protein Glycosylation serves as an excellent text for upper-level undergraduate and graduate students as well as a reference for those scientists whose training is not in glycobiology but who are moving into this field.

Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2
Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Author: David A. Sullivan

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 1013

ISBN-13: 1461553598

DOWNLOAD EBOOK

During the past two decades, a significant international research effort has been di rected toward understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays an essential role in maintaining corneal and conjunctival integrity, protecting against microbial challenge, and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in countless individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perfo ration of the cornea, an increased incidence of infectious disease, and, potentially, pro nounced visual disability and blindness. To promote further progress in this field of vision research, the Second International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance was held at the Southampton Princess Resort in Bermuda November 16-19, 1996. This conference was organized and directed by David A. Sullivan, Ph. D. , codirected by Darlene A. Dartt, Ph. D. , and Michele A. Meneray, Ph. D. , and sponsored by the Schepens Eye Research Institute (Boston, MA), an affiliate of Harvard Medical School. The meeting was designed to assess critically the current knowledge and "state of the art" research on the structure and function of lacrimal tissue, tears, and the ocular sur face in both health and disease.

Glycans in Cell Interaction and Recognition
Glycans in Cell Interaction and Recognition

Author: Michele Aubrey

Publisher: CRC Press

Published: 2002-01-17

Total Pages: 256

ISBN-13: 0203304543

DOWNLOAD EBOOK

Glycoproteins play an important role in the regulation of gene expression, cell growth, migration, differentiation and apoptosis. Over the last decade, research has highlighted the therapeutic implications of glycoproteins for many physiological and pathological processes, such as inflammation, arthritis and metastasis. The first part of the book d

Glycoscience: Biology and Medicine
Glycoscience: Biology and Medicine

Author: Tamao Endo

Publisher: Springer

Published: 2021-01-14

Total Pages:

ISBN-13: 9784431548362

DOWNLOAD EBOOK

The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies. Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book will provide numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

Glycobiology of Innate Immunology
Glycobiology of Innate Immunology

Author: Cheorl-Ho Kim

Publisher: Springer Nature

Published: 2022-03-31

Total Pages: 673

ISBN-13: 9811690812

DOWNLOAD EBOOK

This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.