Glioblastoma:
Glioblastoma:

Author: Swapan K. Ray

Publisher: Springer Science & Business Media

Published: 2009-10-31

Total Pages: 427

ISBN-13: 1441904107

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Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.

Precision Molecular Pathology of Glioblastoma
Precision Molecular Pathology of Glioblastoma

Author: José Javier Otero

Publisher: Springer Nature

Published: 2021-04-30

Total Pages: 266

ISBN-13: 3030691705

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This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists. The book reviews basic principles such as epidemiology and etiology, and modern 2016 WHO classification of CNS tumors. Chapters cover a general overview of common molecular techniques used in molecular pathology, molecular pathology in a developing country, key drivers of patient outcomes and predictors of response to radiation and/or chemotherapy treatment, and immunohistochemical surrogates for key molecular pathology. It concludes with reviews on radiomics, animal and stem cell models of glioblastoma, and a chapter on the emerging field of Glioblastoma Neuroscience. Precision Molecular Pathology of Glioblastoma is intended for pathology residents and fellows interested in glioblastoma, general surgical pathologists who need reviews on how to implement modern glioblastoma classification, as well as neuro-radiologists, oncologists, and radiation oncologists needing a holistic perspective to glioblastoma diagnosis and management.

A Statistic of One
A Statistic of One

Author: Stephen Hatrak

Publisher:

Published: 2012-05

Total Pages: 0

ISBN-13: 9781475916362

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A Statistic of One: My Walk with Glioblastoma Multiforme traces Stephen Hatrak's life from his diagnosis of glioblastoma multiforme, the deadliest of malignant brain tumors, to the present. He chronicles the trials and tribulations he faced and the losses he suffered along his journey. Faith and inner strength are formidable allies in overcoming any tragedy in one's life, and they played vital roles in his struggle. He was told from the start that the he might have twelve months to live; even so, he defi ed the odds and, six years later, is telling his own story. Despite the dire statistics associated with a diagnosis of glioblastoma, there are several stories of long-term survival; these stories gave him hope that this cancer could be tamed. To overcome this challenge in his life, he had to believe in himself and fi nd his inner sixth sense to strengthen his resolve. Along the way, he learned that life with brain cancer could be tough, but that he could be even tougher. What cancer cannot do....separate me from my soul, squash my spirit, and stop the sun from rising in the east and setting in the west; creating new tomorrows and new opportunities. A Statistic of One is an uplifting story of faith and perseverance; how we cope with challenge will determine how we move forward and live life to its fullest.

They Call Me "The Miracle": The Carmen Rice Story
They Call Me

Author: Randy R. Harris

Publisher: Ambassador International

Published: 2021-10-26

Total Pages: 114

ISBN-13: 1649600941

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Cancer is a major worldwide public health problem and is the second leading cause of death in the United States. In 2018, there were seventeen million new cancer cases and 9.5 million cancer deaths worldwide. Seemingly, everyone has been affected by or knows of someone who is affected by the disease. In 2004, doctors discovered that Carmen Rice had a stage 4 Glioblastoma Multiforme brain tumor, one of the deadliest of all cancers—the same cancer which killed John McCain, Edward Kennedy, and Beau Biden. After being diagnosed with a glioblastoma tumor, twenty-nine-year-old Brittany Maynard made headline news when she moved to Oregon to die with dignity. Carmen’s doctor gave her six months to live, but with her faith in God and tenacious spirit, Carmen just kept beating the odds. After all these years, Carmen is “off the map” and into uncharted territory. They Call Me "The Miracle" is her story.

Irreversible Electroporation
Irreversible Electroporation

Author: Boris Rubinsky

Publisher: Springer Science & Business Media

Published: 2009-11-25

Total Pages: 320

ISBN-13: 364205420X

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Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art.

The Heterogeneity of Cancer Metabolism
The Heterogeneity of Cancer Metabolism

Author: Anne Le

Publisher: Springer

Published: 2018-06-26

Total Pages: 186

ISBN-13: 331977736X

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Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Navigating Glioblastoma
Navigating Glioblastoma

Author: Sally Connolly

Publisher: McFarland

Published: 2020-07-10

Total Pages: 211

ISBN-13: 1476641064

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A stale marriage. A deadly diagnosis. For Sally Connolly, three years of struggle followed her husband Peter's surgery for terminal brain cancer at age 61. Choosing treatment options that interfered least with his career, Peter focused his limited energy on work, with little left for his family, further straining the marriage during his remaining days. Connolly's clear-eyed and affecting memoir recounts their wrangling over gender roles, money management, domestic decisions and lifestyle changes. Through their traumatic journey, they find humor and comfort in unexpected places.

Glioblastoma - a Guide for Patients and Loved Ones
Glioblastoma - a Guide for Patients and Loved Ones

Author: Gideon Burrows

Publisher:

Published: 2017-09-15

Total Pages:

ISBN-13: 9780955369551

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Glioblastoma and anaplastic astrocytoma are two of the most common form of brain tumours in adults. Too often they can be life changing, even life limiting for patients, wreaking devastation on their families. This readable, moving and non technical guide is your comprehensive patient focussed guide to these obstinate brain cancers. It covers everything from getting an accurate diagnosis, to dealing with the physical, mental and emotional impact of the disease. From treatment options and how to cope with their side effects, to newly developing techniques and future research. This book presents an honest and realistic picture, with a personal approach. Featuring dozens of personal testimonies from those with these high grade brain tumours and their loved ones, the book offers information, reassurance and support on these, the most complex of brain tumours.

Re-Irradiation: New Frontiers
Re-Irradiation: New Frontiers

Author: Carsten Nieder

Publisher: Springer

Published: 2016-10-25

Total Pages: 368

ISBN-13: 3319418254

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This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.

Intracranial and Spinal Radiotherapy
Intracranial and Spinal Radiotherapy

Author: Lia M. Halasz

Publisher: Springer Nature

Published: 2021-03-08

Total Pages: 208

ISBN-13: 3030645088

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This book is a practical, up-to-date guide to the treatment of patients with brain and spinal tumors. Leading experts in the field explain treatment techniques in detail, highlighting key considerations in the use of external beam radiation therapy, intensity-modulated radiation therapy, particle therapy, radiosurgery, and stereotactic body radiation therapy. Specific recommendations are described for different tumor types, and helpful information provided on other important issues, such as the interaction of radiotherapy and systemic therapy and the avoidance of treatment complications. With the development of modern technology, highly conformal radiotherapy techniques have become more complicated, yet also more widely employed. This book will equip readers with the knowledge required to set up practices to deliver quality brain and spinal radiation therapy appropriate to each patient. It will be of benefit to radiation oncologists, clinical oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses as well as medical oncologists and surgical oncologists with an interest in radiotherapy.