Principles of Developmental Genetics
Principles of Developmental Genetics

Author: Sally A. Moody

Publisher: Elsevier

Published: 2007-07-19

Total Pages: 1094

ISBN-13: 0080550711

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Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.• Includes new research not previously published in any other book on the molecular geneticprocesses that regulates development• Chapters present a broad understanding on the application of animal model systems, allowingresearchers to better treat clinical disorders and comprehend human development• Relates the application of new technologies to the manipulation of stem cells, causes ofhuman birth defects, and several human disease conditions• Each chapter includes a bulleted summary highlighting clinical aspects of animal models

Genetics and Molecular Biology
Genetics and Molecular Biology

Author: Robert F. Schleif

Publisher:

Published: 1993

Total Pages: 724

ISBN-13:

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In the first edition of Genetics and Molecular Biology, renowned researcher and award-winning teacher Robert Schleif produced a unique and stimulating text that was a notable departure from the standard compendia of facts and observations. Schleif's strategy was to present the underlying fundamental concepts of molecular biology with clear explanations and critical analysis of well-chosen experiments. The result was a concise and practical approach that offered students a real understanding of the subject. This second edition retains that valuable approach--with material thoroughly updated to include an integrated treatment of prokaryotic and eukaryotic molecular biology. Genetics and Molecular Biology is copiously illustrated with two-color line art. Each chapter includes an extensive list of important references to the primary literature, as well as many innovative and thought-provoking problems on material covered in the text or on related topics. These help focus the student's attention of a variety of critical issues. Solutions are provided for half of the problems. Praise for the first edition: "Schleif's Genetics and Molecular Biology... is a remarkable achievement. It is an advanced text, derived from material taught largely to postgraduates, and will probably be thought best suited to budding professionals in molecular genetics. In some ways this would be a pity, because there is also gold here for the rest of us... The lessons here in dealing with the information explosion in biology are that an ounce of rationale is worth a pound of facts and that, for educational value, there is nothing to beat an author writing about stuff he knows from theinside."--Nature. "Schleif presents a quantitative, chemically rigorous approach to analyzing problems in molecular biology. The text is unique and clearly superior to any currently available."--R.L. Bernstein, San Francisco State University. "The greatest strength is the author's ability to challenge the student to become involved and get below the surface."--Clifford Brunk, UCLA

Scientific Frontiers in Developmental Toxicology and Risk Assessment
Scientific Frontiers in Developmental Toxicology and Risk Assessment

Author: National Research Council

Publisher: National Academies Press

Published: 2000-12-21

Total Pages: 348

ISBN-13: 0309070864

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Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Developmental Genetics and Plant Evolution
Developmental Genetics and Plant Evolution

Author: Quentin C.B. Cronk

Publisher: CRC Press

Published: 2004-01-29

Total Pages: 568

ISBN-13: 9781420024982

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A benchmark text, Developmental Genetics and Plant Evolution integrates the recent revolution in the molecular-developmental genetics of plants with mainstream evolutionary thought. It reflects the increasing cooperation between strongly genomics-influenced researchers, with their strong grasp of technology, and evolutionary morphogenetists and sys

Genetics of Bone Biology and Skeletal Disease
Genetics of Bone Biology and Skeletal Disease

Author: Rajesh V. Thakker

Publisher: Academic Press

Published: 2017-10-31

Total Pages: 880

ISBN-13: 0128041986

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Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Dictionary of Developmental Biology and Embryology
Dictionary of Developmental Biology and Embryology

Author: Frank J. Dye

Publisher: John Wiley & Sons

Published: 2012-02-21

Total Pages: 257

ISBN-13: 1118076516

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A newly revised edition of the standard reference for the field today—updated with new terms, major discoveries, significant scientists, and illustrations Developmental biology is the study of the mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, and genetic levels. The discipline has gained prominence in part due to new interdisciplinary approaches and advances in technology, which have led to the rapid emergence of new concepts and words. The Dictionary of Developmental Biology and Embryology, Second Edition is the first comprehensive reference focused on the field's terms, research, history, and people. This authoritative A-to-Z resource covers classical morphological and cytological terms along with those from modern genetics and molecular biology. Extensively cross-referenced, the Dictionary includes definitions of terms, explanations of concepts, and biographies of historical figures. Comparative aspects are described in order to provide a sense of the evolution of structures, and topics range from fundamental terminology, germ layers, and induction to RNAi, evo-devo, stem cell differentiation, and more. Readers will find such features of embryology and developmental biology as: Vertebrates Invertebrates Plants Developmental genetics Evolutionary developmental biology Molecular developmental biology Medical embryology The author's premium on accessibility allows readers at all levels to enhance their vocabulary in their field and understand terminology beyond their specific focus. Researchers and students in developmental biology, cell biology, developmental genetics, and embryology will find the dictionary to be a vital resource.

A History of Genetics
A History of Genetics

Author: Alfred Henry Sturtevant

Publisher: CSHL Press

Published: 2001

Total Pages: 190

ISBN-13: 9780879696078

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In the small “Fly Room†at Columbia University, T.H. Morgan and his students, A.H. Sturtevant, C.B. Bridges, and H.J. Muller, carried out the work that laid the foundations of modern, chromosomal genetics. The excitement of those times, when the whole field of genetics was being created, is captured in this book, written in 1965 by one of those present at the beginning. His account is one of the few authoritative, analytic works on the early history of genetics. This attractive reprint is accompanied by a website, http://www.esp.org/books/sturt/history/ offering full-text versions of the key papers discussed in the book, including the world's first genetic map.

Mammalian Development
Mammalian Development

Author: Patrick P. L. Tam

Publisher:

Published: 2013

Total Pages: 0

ISBN-13: 9781936113248

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"A subject collection from Cold Spring Harbor perspectives in biology."