Fungal Secondary Metabolism
Fungal Secondary Metabolism

Author: Nancy P. Keller

Publisher: Humana Press

Published: 2012-10-14

Total Pages: 288

ISBN-13: 9781627031219

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Filamentous fungi have long been known for their ability to produce an enormous range of unusual chemical compounds known as secondary metabolites, many of which have potentially useful antibiotic or pharmacological properties. Recent focus on fungal genomics coupled with advances in detection and molecular manipulation techniques has galvanized a revitalization of this field. Fungal Secondary Metabolism: Methods and Protocols is aimed at providing the key methodologies currently in use and necessary for accessing and exploiting the natural product information provided by the genomes of this large and varied kingdom. Written by active researchers in the field, the chapters deal with all the steps necessary, from optimization of fungal culture conditions for metabolite production, through rapid genome sequencing and bioinformatics, and genetic manipulations for functional analysis, to detection and testing of metabolites. In addition, chapters on basic science address approaches to the genetic regulation, protein biochemistry, and cellular localization of the biosynthetic pathways. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and hands-on, Fungal Secondary Metabolism: Methods and Protocols encourages new investigators to enter the field and expands upon the expertise and range of skills of those already researching fungal natural products.

Gene Expression Systems in Fungi: Advancements and Applications
Gene Expression Systems in Fungi: Advancements and Applications

Author: Monika Schmoll

Publisher: Springer

Published: 2016-04-04

Total Pages: 505

ISBN-13: 3319279513

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Biotechnology has emerged as one of the key environmentally safe technologies for the future which enables use of biomass to develop novel smart materials and to replace oil derived products. Fungi are the most efficient producers of the enzymes needed for this purpose and in addition they produce a plethora of secondary metabolites, among which novel antibiotics can be found. Industrial application and exploitation of the metabolic capacities of fungi requires highly productive and robust gene expression systems, which can be achieved by selection of appropriate species and strain improvement. In this book we aim to summarize homologous and heterologous gene expression systems of fungi for production of enzymes and secondary metabolites. A broad overview on requirements, challenges and successful applications shall serve as a basis for further development of fungi as biotechnological workhorses in research and industry.

Microbial Technology for the Welfare of Society
Microbial Technology for the Welfare of Society

Author: Pankaj Kumar Arora

Publisher: Springer Nature

Published: 2019-09-12

Total Pages: 343

ISBN-13: 981138844X

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This book describes various aspects of modern microbiology including microbial enzymes, secondary metabolites, next-generation sequencing, microbial-based biopesticides, microbial-based cancer therapies, biodiesel, and microbial products from fermentation, biodegradation, bioremediation and wastewater treatment. Further, it explains how and why microbes play an important role in preserving the welfare of living beings and the environment. Many bacteria play a significant part in cleaning our environment by detoxifying various xenobiotic compounds, while several microbes produce secondary metabolites that are useful to human beings. The book is divided into 15 chapters that cover various aspects of microorganism-based biotechnology, including recent methodologies such as advanced molecular techniques, as well developments in classical microbiological techniques. The authors also explain how the latest and classical techniques are being used in modern-day microbial biotechnology. All chapters were written by experts from prominent universities, research laboratories, and institutes around the globe. Above all, they focus on recent advances in microbial technology that promote the welfare of living beings and the environment.

Endophytes and Secondary Metabolites
Endophytes and Secondary Metabolites

Author: Sumita Jha

Publisher: Springer

Published: 2019-07-24

Total Pages: 0

ISBN-13: 9783319904832

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This reference work presents an authoritative review of endophytes and their applications to human welfare. Endophytes have become a class of interesting and curious microorganisms due to their intimate intra- and intercellular association with plants for competence, survival and reproduction. They can be bacteria or fungi, and they are usually non-pathogenic to their host. Endophytes have important applications in agriculture and industry, namely, they can help with plant growth, act as biocontrol agents and biosurfactant and secondary metabolite producers, and they are also rich sources of bioactive natural products. Novel and beneficial effects of endophytes are constantly emerging, and this book, divided into four sections, provides readers with the latest developments in this fast expanding field. In the first section, readers will discover the biology of the major groups of endophytes, followed by a summary of conventional and molecular tools for endophytes’ identification in Section II. The production of high-value metabolites by endophytes will be explored in the third section of this book, and in the final section, readers will find several case studies, examples and prospects for endophytes’ application in agriculture and industry. Written by leading international authors, this reference work will appeal to a wide readership, from students and researchers in the field of botany, biotechnology and agriculture to professionals interested in the production and applications of endophytic metabolites.

Natural Compounds as Drugs, Volume II
Natural Compounds as Drugs, Volume II

Author: Frank Petersen

Publisher: Springer Science & Business Media

Published: 2008-07-29

Total Pages: 425

ISBN-13: 3764385952

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The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. A compilation of current applicable technology makes this a brilliant reference work.

Secondary Metabolites in Soil Ecology
Secondary Metabolites in Soil Ecology

Author: Petr Karlovsky

Publisher: Springer Science & Business Media

Published: 2008-01-03

Total Pages: 296

ISBN-13: 3540745432

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Microbiologists and soil scientists will find this study compelling reading. It focuses on the role of bacterial, fungal and plant secondary metabolites in soil ecosystems. Our understanding of the biological function of secondary metabolites is surprisingly limited, considering our knowledge of their structural diversity and pharmaceutical activity. This book reviews functional aspects of secondary metabolite production, with a focus on interactions among soil organisms.

Fungal Biomolecules
Fungal Biomolecules

Author: Vijai Kumar Gupta

Publisher: John Wiley & Sons

Published: 2015-04-20

Total Pages: 412

ISBN-13: 1118958292

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Fungi have an integral role to play in the development of the biotechnology and biomedical sectors. The fields of chemical engineering, Agri-food,Biochemical, pharmaceuticals, diagnostics and medical device development all employ fungal products, with fungal biomolecules currently used in a wide range of applications, ranging from drug development to food technology and agricultural biotechnology. Understanding the biology of different fungi in diverse ecosystems, as well as their biotropic interactions with other microorganisms, animals and plants, is essential to underpin effective and innovative technological developments. Fungal Biomolecules is a keystone reference, integrating branches of fungal product research into a comprehensive volume of interdisciplinary research. As such, it: reflects state-of-the-art research and current emerging issues in fungal biology and biotechnology reviews the methods and experimental work used to investigate different aspects of fungal biomolecules provides examples of the diverse applications of fungal biomolecules in the areas of food, health and the environment is edited by an experienced team, with contributions from international specialists This book is an invaluable resource for industry-based researchers, academic institutions and professionals working in the area of fungal biology and associated biomolecules for their applications in food technology, microbial and biochemical process, biotechnology, natural products, drug development and agriculture.

Fusarium Species
Fusarium Species

Author: Abraham Z. Joffe

Publisher: Wiley-Interscience

Published: 1986-08-14

Total Pages: 616

ISBN-13:

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This clear, in-depth guide describes the Fusarium genus and its toxins--a widespread group of plant pathogens associated with disease and sometimes death in humans and livestock and implicated as the active agent in ``yellow rain.'' Noted authority Abraham Joffe presents new and original research into the biology of the Fusarium and the chemistry, biochemical and toxicological properties of their toxins.