Hereditary Colorectal Cancer

Hereditary Colorectal Cancer

Author: Joji Utsunomiya

Publisher: Springer Science & Business Media

Published: 2013-11-27

Total Pages: 564

ISBN-13: 4431683372

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Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.


Modern Clinical Molecular Techniques

Modern Clinical Molecular Techniques

Author: Peter Hu

Publisher: Springer Science & Business Media

Published: 2012-05-11

Total Pages: 428

ISBN-13: 1461421705

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This timely book covers the need to know clinical practices for all those involved in molecular laboratory science. The field of molecular medicine is evolving at an astounding speed. Propelled by the new insights and technologies, advances are being made at an unprecedented rate. With dual measure given to today’s breakthroughs, this book is a collection of the most current practices relevant to the clinical molecular laboratorian. It begins with an introductory section on techniques and procedure. It then presents four separate sections on infectious disease, oncology, pre/post-natal, and identity testing, with specific chapters clearly outlining clinical protocols used in daily practice. Modern Clinical Molecular Techniques cuts to the heart of what is essential for the practicing molecular laboratory scientist. It is an outstanding resource for those operating within or looking to set up a clinical molecular laboratory.


Absolute Clinical Radiation Oncology Review

Absolute Clinical Radiation Oncology Review

Author: Daniel M. Trifiletti

Publisher: Springer

Published: 2019-01-22

Total Pages: 492

ISBN-13: 3319968092

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This book provides a quick reference guide for clinicians in radiation oncology. It is designed to be an intuitive and easily reviewed study guide for board or maintenance of certification examinations, as well as a quick reference for residents and established radiation oncologists who need a refresher. The text begins with a general pearls chapter that radiation oncologists should consider in all aspects of their practice, including cancer visibility, dosing, counseling recommendations, and toxicity management. The subsequent chapters then delve into different cancer disease sites, including pediatrics, central nervous system, head and neck, thoracic, breast, gastrointestinal, gynecologic, genitourinary, hematologic, soft tissue, palliative, and radiophysics/radiobiology. Within each chapter, each disease and its recommended approach is then summarized in only a few pages, allowing a focus on the most essential information. Bullet points, figures, tables, and images make for an intuitive reader experience. Recommendations are taken from the American Society for Radiation Oncology (ASTRO), the European Society for Radiation Oncology (ESTRO), and the National Comprehensive Cancer Network (NCCN). Planning guides for imaging, diagnosis, and staging offer readers a starting point in approaching each patient based on disease origin, and dosing guidelines then detail consideration for treatment methods. Each chapter additionally includes disease-specific pearls and key points to test the knowledge reviewed in the chapters. Experts in the disease sites from the United States serve as senior authors on each chapter. The authors include all diseases associated with radiation oncology training to ensure a comprehensive resource for exam studying and clinical care. Residents, trainees, and established radiation oncologists find this an ideal study resource for both board and certification exams, as well as an easily accessible aid during practice.


13th International Conference on Theory and Application of Fuzzy Systems and Soft Computing — ICAFS-2018

13th International Conference on Theory and Application of Fuzzy Systems and Soft Computing — ICAFS-2018

Author: Rafik A. Aliev

Publisher: Springer

Published: 2018-12-28

Total Pages: 970

ISBN-13: 3030041646

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This book presents the proceedings of the 13th International Conference on Application of Fuzzy Systems and Soft Computing (ICAFS 2018), held in Warsaw, Poland on August 27–28, 2018. It includes contributions from diverse areas of soft computing such as uncertain computation, Z-information processing, neuro-fuzzy approaches, evolutionary computing and others. The topics of the papers include theory of uncertainty computation; theory and application of soft computing; decision theory with imperfect information; neuro-fuzzy technology; image processing with soft computing; intelligent control; machine learning; fuzzy logic in data analytics and data mining; evolutionary computing; chaotic systems; soft computing in business, economics and finance; fuzzy logic and soft computing in the earth sciences; fuzzy logic and soft computing in engineering; soft computing in medicine, biomedical engineering and the pharmaceutical sciences; and probabilistic and statistical reasoning in the social and educational sciences. The book covers new ideas from theoretical and practical perspectives in economics, business, industry, education, medicine, the earth sciences and other fields. In addition to promoting the development and application of soft computing methods in various real-life fields, it offers a useful guide for academics, practitioners, and graduates in fuzzy logic and soft computing fields.


Salt Sugar Fat

Salt Sugar Fat

Author: Michael Moss

Publisher: Signal

Published: 2013-02-26

Total Pages: 461

ISBN-13: 0771057091

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From a Pulitzer Prize-winning investigative reporter at The New York Times comes the troubling story of the rise of the processed food industry -- and how it used salt, sugar, and fat to addict us. Salt Sugar Fat is a journey into the highly secretive world of the processed food giants, and the story of how they have deployed these three essential ingredients, over the past five decades, to dominate the North American diet. This is an eye-opening book that demonstrates how the makers of these foods have chosen, time and again, to double down on their efforts to increase consumption and profits, gambling that consumers and regulators would never figure them out. With meticulous original reporting, access to confidential files and memos, and numerous sources from deep inside the industry, it shows how these companies have pushed ahead, despite their own misgivings (never aired publicly). Salt Sugar Fat is the story of how we got here, and it will hold the food giants accountable for the social costs that keep climbing even as some of the industry's own say, "Enough already."


Stem Cells & Regenerative Medicine

Stem Cells & Regenerative Medicine

Author: Krishnarao Appasani

Publisher: Springer Science & Business Media

Published: 2010-11-01

Total Pages: 632

ISBN-13: 1607618605

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Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.


Human Chromosomes

Human Chromosomes

Author: Orlando J. Miller

Publisher: Springer Science & Business Media

Published: 2011-06-28

Total Pages: 508

ISBN-13: 1461301394

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The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. This new edition continues to cover both basic and up-to-date material on normal and defective chromosomes, yet is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes.