Modified Cyclodextrins for Chiral Separation

Modified Cyclodextrins for Chiral Separation

Author: Weihua Tang

Publisher: Springer Science & Business Media

Published: 2013-05-24

Total Pages: 266

ISBN-13: 3642376487

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Modified Cyclodextrins for Chiral Separation offers a review of the latest advances in developing modified cyclodextrins as chiral selectors for various chromatographic and electromigration techniques. Over the years, many descriptions of chiral separation have appeared in academic journals and books, but most of them have been devoted to either the development of analytical methods and protocols or the summary of different chiral selectors, including cyclodextrins for chiral separation applications. This is in marked contrast to this volume which focuses on the research endeavors concerning the development of cyclodextrin derivatives specifically as either chiral mobile phases for capillary electrophoresis, or chiral stationary phases for various chromatographic techniques including gas chromatography, or high-performance liquid chromatography and supercritical fluid chromatography. The ongoing thread in this book is the synthesis of structurally-defined cyclodextrin derivatives and their applications in enantiomer separation by means of different analytical techniques. Modified Cyclodextrins for Chiral Separation is intended for those who are interested in expanding their knowledge of cyclodextrin chemistry and chiral separation, and in what cyclodextrin modification can be made to suit the needs of chiral selectors for different analytical techniques. It primarily focuses on the state-of-the-art cyclodextrin chemistry which is the basis for all chiral selectors used in these chiral separation techniques. Weihua Tang, PhD, is a professor at the Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, China. Siu-Choon Ng, PhD, is a professor at the Division of Chemical and Biomedical Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore. Dongping Sun, PhD, is a professor at the Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, China.


Enantiomer Separation

Enantiomer Separation

Author: Fumio Toda

Publisher: Springer Science & Business Media

Published: 2007-11-04

Total Pages: 334

ISBN-13: 1402023375

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In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.


Differentiation of Enantiomers I

Differentiation of Enantiomers I

Author: Volker Schurig

Publisher: Springer

Published: 2013-12-16

Total Pages: 286

ISBN-13: 3319032399

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The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.


Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Author: Satinder Ahuja

Publisher: John Wiley & Sons

Published: 2011-03-31

Total Pages: 474

ISBN-13: 1118097750

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Discusses chiral separations and offers guidance for selecting the optimum method for desired results Chiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds. This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development. Considering chiral separations in the biotechnological and pharmaceutical industries, as well as for food applications, Dr. Ahuja provides insights into a broad range of topics. Opening with a broad overview of chiral separations, regulatory considerations in drug product development, and basic issues in method development, the book: Covers a variety of modern methods such as gas chromatography, high performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity of small and large molecules Provides detailed information on useful chiral stationary phases (CSPs) for HPLC Includes handy information on selection of an appropriate CSP, including mechanistic studies Offers strategies for fast method development with HPLC, SFC, and CE Discusses preparatory methods utilized in the pharmaceutical industry With in-depth discussions of the current state of the field as well as suggestions to assist future developments, Chiral Separation Methods for Pharmaceutical and Biotechnological Products is an essential text for laboratory investigators, managers, and regulators who are involved in chiral separations in the pharmaceutical industry, as well as students preparing for careers in these fields.


Handbook of Methods and Instrumentation in Separation Science

Handbook of Methods and Instrumentation in Separation Science

Author:

Publisher: Academic Press

Published: 2009-11-11

Total Pages: 881

ISBN-13: 0123757274

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Handbook of Methods and Instrumentation in Separation Science, Volume 1 provides concise overviews and summaries of the main methods used for separation. It is based on the Encyclopedia of Separation Science. The handbook focuses on the principles of methods and instrumentation. It provides general concepts concerning the subject matter; it does not present specific procedures. This volume discusses the separation processes including affinity methods, analytical ultracentrifugation, centrifugation, chromatography, and use of decanter centrifuge and dye. Each methodology is defined and compared with other separation processes. It also provides specific techniques, principles, and theories concerning each process. Furthermore, the handbook presents the applications, benefits, and validation of the processes described in this book. This handbook is an excellent reference for biomedical researchers, environmental and production chemists, flavor and fragrance technologists, food and beverage technologists, academic and industrial librarians, and nuclear researchers. Students and novices will also find this handbook useful for practice and learning. - One-stop source for information on separation methods - General overviews for quick orientation - Ease of use for finding results fast - Expert coverage of major separation methods - Coverage of techniques for all sizes of samples, pico-level to kilo-level


Analytical Separation Science, 5 Volume Set

Analytical Separation Science, 5 Volume Set

Author: Jared Anderson

Publisher: John Wiley & Sons

Published: 2016-02-29

Total Pages: 2148

ISBN-13: 3527333746

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Endlich ein Forschungsleitfaden für Wissenschaftler des Fachgebiets, die neue Methoden entwickeln oder einsetzen. Dieses Handbuch umfasst fünf thematische Bände und bietet damit einen umfassenden Überblick über das Fachgebiet. Erläutert werden Grundlagen, die Methodenentwicklung und hochkarätige Anwendungen für alle wichtigen Analyseverfahren, darunter chromatische Verfahren, Techniken in den Bereichen Elektromigration und Membranen. Dieses Referenzwerk umfasst ein breites Spektrum und legt den Schwerpunkt auf Entwicklungen für die Zukunft. Damit ist es ein Muss für Forscher und eine wertvolle Wissensquelle für Studenten im Hauptstudium und Studienabsolventen.


Bio-Targets and Drug Delivery Approaches

Bio-Targets and Drug Delivery Approaches

Author: Sabyasachi Maiti

Publisher: CRC Press

Published: 2016-11-03

Total Pages: 611

ISBN-13: 1498730000

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The advances in drug delivery systems over recent years have resulted in a large number of novel delivery systems with the potential to revolutionize the treatment and prevention of diseases. Bio-Targets and Drug Delivery Approaches is an easy-to-read book for students, researchers and pharmaceutical scientists providing a comprehensive introduction to the principles of advanced drug delivery and targeting their current applications and potential future developments.


TRAC: Trends in Analytical Chemistry

TRAC: Trends in Analytical Chemistry

Author: Y. Gohshi

Publisher: Elsevier

Published: 2013-09-17

Total Pages: 617

ISBN-13: 1483274691

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Trends in Analytical Chemistry, Volume 12 focuses on the advancements of processes, technologies, automation, and applications of analytical chemistry. The selection first offers information on single-cell analysis at the level of a single human erythrocyte and micellar catalysis in reaction-rate methods. Topics include analytical strategies, analysis of single erythrocytes, kinetic aspects of micellar catalysis, and micellar kinetic multicomponent determination. The text then takes a look at advances in the field of laser atomic spectroscopy and molecular recognition of sugars, including detection of sugar complexation, driving force and selectivity of sugar complexation, atomization/excitation source, and diagnostic tool. The manuscript examines charge-remote fragmentations for structural determination of lipids; advances in speciation analysis by capillary gas chromatography; and chemical pattern recognition and multivariate analysis for QSAR studies. The publication also ponders on in-vivo microdialysis sampling in pharmacokinetic studies; a novel single beam optical spectrophotometer for fast luminescence, absorption, and reflection measurements of turbid materials; and techniques for the study and characterization of advanced materials. The selection is a dependable reference for readers interested in the trends in analytical chemistry.