Growth Hormone in Adults
Growth Hormone in Adults

Author: Anders Juul

Publisher: Cambridge University Press

Published: 2000-04-27

Total Pages: 536

ISBN-13: 9780521641883

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This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.

Growth Hormone Deficiency in Adults
Growth Hormone Deficiency in Adults

Author: Jens O. L. Jørgensen

Publisher: Karger Medical and Scientific Publishers

Published: 2005-01-01

Total Pages: 241

ISBN-13: 3805579926

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It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Gigantism and Acromegaly
Gigantism and Acromegaly

Author: Constantine A. Stratakis

Publisher: Academic Press

Published: 2021-06-01

Total Pages: 312

ISBN-13: 0128145382

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Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. - Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism - Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics - Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism

The Passion According to G.H.
The Passion According to G.H.

Author: Clarice Lispector

Publisher: New Directions Publishing

Published: 2012-06-13

Total Pages: 209

ISBN-13: 0811220699

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Lispector’s most shocking novel. The Passion According to G.H., Clarice Lispector’s mystical novel of 1964, concerns a well-to-do Rio sculptress, G.H., who enters her maid’s room, sees a cockroach crawling out of the wardrobe, and, panicking, slams the door—crushing the cockroach—and then watches it die. At the end of the novel, at the height of a spiritual crisis, comes the most famous and most genuinely shocking scene in Brazilian literature… Lispector wrote that of all her works this novel was the one that “best corresponded to her demands as a writer.”

Human Growth Hormone
Human Growth Hormone

Author: Adair Stuart Mason

Publisher:

Published: 1972

Total Pages: 218

ISBN-13:

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Human Growth Hormone is a compendium of papers that discusses all aspects of human growth hormone (HGH) relevant in the treatment of dwarfs who are HGH deficient. This book discusses the approach of growth hormone treatment including the preparation of the hormone, its effect and interactions with other hormones, the methods used to detect growth hormone in human plasma, as well as its clinical applications. One author discusses the preparation of human growth hormone, its storage, method of bioassay, and procedures for ampouling HGH for clinical use. A couple of authors review the metabolic a ...

Growth Hormone Secretagogues
Growth Hormone Secretagogues

Author: E. Ghigo

Publisher: Elsevier

Published: 1999-09-07

Total Pages: 341

ISBN-13: 0080532691

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Growth hormone secretagogues (GHS) administered alone or in combination with growth hormone releasing hexapeptides, are effective probes for the diagnosis of GH deficiency in both children and adults. Current research has developed and tested different GHS compounds that are active by the oral route, and have improved potency and bioavailability, giving rise to exciting therapeutic possibilities. There was an enthusiastic response from experts in this area to the idea of distilling the huge amount of available data into one multi-authored volume. Each contributor has advanced the field of knowledge, and has here emphasized the practical aspects of their work, reviewing the subject in the light of their own experience. Therefore, the theme of the book is a practical one. The volume deals with all aspects of GHS that are relevant to the field, from the chemical structure to the different analogues, to the cloning and expression of the GHS-receptor and the role of these compounds in the physiological control of GH secretion. Also discussed are the most recent advances in relation to the possible role of these compounds in the diagnostic therapeutic settings in different clinical situations, either in children, adults or the elderly. The book meets the requirement of covering most, if not all of the advances in the field. It will enable scientists and clinicians to keep abreast of the rapidly evolving knowledge of the most recent years, and will also prove useful as a review for all interested in this topic.

Growth Hormone Therapy in Pediatrics
Growth Hormone Therapy in Pediatrics

Author: Michael B. Ranke

Publisher: Karger Medical and Scientific Publishers

Published: 2007-01-01

Total Pages: 534

ISBN-13: 3805582560

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For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.

Who
Who

Author: Geoff Smart

Publisher: Ballantine Books

Published: 2008-09-30

Total Pages: 210

ISBN-13: 0345504194

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In this instant New York Times Bestseller, Geoff Smart and Randy Street provide a simple, practical, and effective solution to what The Economist calls “the single biggest problem in business today”: unsuccessful hiring. The average hiring mistake costs a company $1.5 million or more a year and countless wasted hours. This statistic becomes even more startling when you consider that the typical hiring success rate of managers is only 50 percent. The silver lining is that “who” problems are easily preventable. Based on more than 1,300 hours of interviews with more than 20 billionaires and 300 CEOs, Who presents Smart and Street’s A Method for Hiring. Refined through the largest research study of its kind ever undertaken, the A Method stresses fundamental elements that anyone can implement–and it has a 90 percent success rate. Whether you’re a member of a board of directors looking for a new CEO, the owner of a small business searching for the right people to make your company grow, or a parent in need of a new babysitter, it’s all about Who. Inside you’ll learn how to • avoid common “voodoo hiring” methods • define the outcomes you seek • generate a flow of A Players to your team–by implementing the #1 tactic used by successful businesspeople • ask the right interview questions to dramatically improve your ability to quickly distinguish an A Player from a B or C candidate • attract the person you want to hire, by emphasizing the points the candidate cares about most In business, you are who you hire. In Who, Geoff Smart and Randy Street offer simple, easy-to-follow steps that will put the right people in place for optimal success.

G.H. Mead
G.H. Mead

Author: G. H. Mead

Publisher: Routledge

Published: 2011-05-16

Total Pages: 448

ISBN-13: 1135262233

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This book introduces social scientists to the ideas of George Herbert Mead (1863-1931) - one of the most original yet neglected thinkers of early twentieth century sociology. Mead is an exceptional case amongst sociological classics in that, until now, there has been no comprehensive reader of his work. As the first one-volume, comprehensive edited collection of Mead’s published and unpublished writing, this book fills this gap. It is the first to critically assess all of Mead's writings and draw out the aspects that are central to his system of thought. The book is divided into three parts (social psychology, science and epistemology, and democratic politics), comprising a total of 30 chapters - a third of which are published here for the first time. G.H. Mead: A Reader provides a unique and timely contribution to the understanding of this key theorist. It is essential reading for both undergraduate and postgraduate students in the fields of sociology, social psychology, philosophy of social science, social and cultural anthropology, and social and political theory.

Sex-Steroid Interactions with Growth Hormone
Sex-Steroid Interactions with Growth Hormone

Author: Johannes D. Veldhuis

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 367

ISBN-13: 1461215463

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Sex-Steroid Interactions with Growth Hormone presents the proceedings of an international symposium held from October 22-25 in Naples, Florida. The proceedings provide new insights and concepts gained by molecular, cellular and neuroendocrine research into mechanistic interactions of the reproductive and somatotrophic axes. Chapters include discussions of the impact of sex steroids on growth hormone secretion in both children and adults; sex steroids, growth hormone releasing factor, and somatostatin; how sex steroids modulate growth hormone action on target issues; and differential effects of growth hormone secretagogues in men and women. This volume is designed for physicians, scientists and other health professionals interested or trained in clinical and basic endocrinology, growth or reproduction.