This three-volume set is a desirable reference for a wide range of specialists who study secondary fungal metabolites ranging from pharmaceutical house researchers, agricultural researchers, those involved in food and feed control regulation, and veterinary researchers. It discusses in depth the molecular formula of, the molecular weights of, and fungal/plant source indexes of secondary fungal metabolites.
Handbook of Toxic Fungal Metabolites presents UV, IR, 1H NMR, 13C NMR, and mass spectra for identification of known mycotoxins or related metabolites by both chemists and researchers. The handbook is oriented primarily toward fungal metabolites that elicit a toxic response in vertebrate animals. It also contains metabolites that show little or no known acute toxicity. The handbook is divided into 21 sections. Mycotoxin and fungal metabolite members are considered into each section based on their chemical relationships, except for the last four groups, Aspergillus, Penicillium, Fusarium, and miscellaneous toxins. The final section focuses on miscellaneous toxins that could not be classified under the considered categories, namely slaframine, diplodiatoxin, and roseotoxin B. This handbook is of great value to mycotoxicologists, and food and feed researchers.
The purpose of this book was not to provide a comprehensive overview of the vast arena of how fungi and fungal metabolites are able to improve human and animal nutrition and health; rather, we, as Guest Editors, wished to encourage authors working in this field to publish their most recent work in this rapidly growing journal in order for the large readership to appreciate the full potential of wonderful and beneficial fungi. Thus, this Special Issue welcomed scientific contributions on applications of fungi and fungal metabolites, such as bioactive fatty acids, pigments, polysaccharides, alkaloids, terpenoids, etc., with great potential in human and animal nutrition and health.
Primary and secondary metabolism; Fungi, their cultivation and their secondary metabolism; Secondary metabolites derived without the intervention of acetate; Secondary metabolites derived from fatty acids; Polyketides; Terpenes and steroids; Secondary metabolites derived from intermediates of the tricarboxylic acid cycle; Secondary metabolites derived from amino-acids; Miscellaneous secondary metabolites; Addendum; Formula index; Organism index; Subject index.
Microbiologists and soil scientists will find this study compelling reading. It focuses on the role of bacterial, fungal and plant secondary metabolites in soil ecosystems. Our understanding of the biological function of secondary metabolites is surprisingly limited, considering our knowledge of their structural diversity and pharmaceutical activity. This book reviews functional aspects of secondary metabolite production, with a focus on interactions among soil organisms.
Filamentous fungi have long been known for their ability to produce an enormous range of unusual chemical compounds known as secondary metabolites, many of which have potentially useful antibiotic or pharmacological properties. Recent focus on fungal genomics coupled with advances in detection and molecular manipulation techniques has galvanized a revitalization of this field. Fungal Secondary Metabolism: Methods and Protocols is aimed at providing the key methodologies currently in use and necessary for accessing and exploiting the natural product information provided by the genomes of this large and varied kingdom. Written by active researchers in the field, the chapters deal with all the steps necessary, from optimization of fungal culture conditions for metabolite production, through rapid genome sequencing and bioinformatics, and genetic manipulations for functional analysis, to detection and testing of metabolites. In addition, chapters on basic science address approaches to the genetic regulation, protein biochemistry, and cellular localization of the biosynthetic pathways. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and hands-on, Fungal Secondary Metabolism: Methods and Protocols encourages new investigators to enter the field and expands upon the expertise and range of skills of those already researching fungal natural products.
Fungi occupy an important place in the natural world, as non-photosynthetic organisms, they obtain their nutrients from the degradation of organic material. They use many of their secondary metabolites to secure a place in a competitive natural environment and to protect themselves from predation. The diverse structures, biosyntheses and biological activities of fungal metabolites have attracted chemists for many years. Fungi are ubiquitous and their activities affect many aspects of our daily lives whether it be as sources of pharmaceuticals and food or as spoilage organisms and the causes of.
This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
