Post-translational Modifications of Proteins
Post-translational Modifications of Proteins

Author: Christoph Kannicht

Publisher: Humana Press

Published: 2008-04-01

Total Pages: 0

ISBN-13: 9781588297198

DOWNLOAD EBOOK

This is a fully up-dated and expanded practical guide to protein structure-function relationships. This important area of research is brought up-to-date by the leading scientists in the field. The compilation of detailed protocols focuses on protein function, proteome research and characterization of pharmaceutical proteins, while following the successful format of the Methods in Molecular BiologyTM series. Comprehensive and cutting edge, the book serves as practical guide for researchers working in the field of protein structure-function relationships and the rapidly growing field of proteomics, as well as scientists in the pharmaceutical industries.

Functional Proteomics
Functional Proteomics

Author: Luke Erber

Publisher: American Chemical Society

Published: 2021-12-30

Total Pages: 161

ISBN-13: 0841299242

DOWNLOAD EBOOK

The fundamental importance of proteins in cellular activity and drug discovery combined with the enormous complexity of proteoforms requires wide-ranging strategies to characterize the proteome at a system-wide scale. Because of its speed, sensitivity, and reliability, mass spectrometry–based proteomics technology has become a critical platform for systematic analysis of proteins. Functional Proteomics covers the basic knowledge about and summarizes some of the latest developments in this field as an introduction for anyone interested in applying functional proteomics strategies to study biological pathways and diseases.

Functional Proteomics
Functional Proteomics

Author: Julie D. Thompson

Publisher: Humana Press

Published: 2008-08-12

Total Pages: 0

ISBN-13: 9781588299710

DOWNLOAD EBOOK

As the emerging field of proteomics continues to expand at an extremely rapid rate, the relative quantification of proteins, targeted by their function, becomes its greatest challenge. Complex analytical strategies have been designed that allow comparative analysis of large proteomes, as well as in depth detection of the core proteome or the interaction network of a given protein of interest. In Functional Proteomics: Methods and Protocols, expert researchers describe the latest protocols being developed to address the problems encountered in high-throughput proteomics projects, with emphasis on the factors governing the technical choices for given applications. The case studies within the volume focus on the following three crucial aspects of the experimental design: 1) the strategy used for the selection, purification and preparation of the sample to be analyzed by mass spectrometry, 2) the type of mass spectrometer used and the type of data to be obtained from it, and 3) the method used for the interpretation of the mass spectrometry data and the search engine used for the identification of the proteins in the different types of sequence data banks available. As a part of the highly successful Methods in Molecular BiologyTM series, the chapters compile step-by-step, readily reproducible laboratory protocols, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Functional Proteomics: Methods and Protocols is an ideal resource for all scientists pursuing this developing field and its multitudinous data.

Functional Proteomics and Nanotechnology-Based Microarrays
Functional Proteomics and Nanotechnology-Based Microarrays

Author: Josh LaBaer

Publisher: CRC Press

Published: 2019-05-08

Total Pages: 212

ISBN-13: 0429533772

DOWNLOAD EBOOK

This volume introduces in a coherent and comprehensive fashion the Pan Stanford Series on Nanobiobiotechnology by defining and reviewing the major sectors of Nanobiotechnology and Nanobiosciences with respect to the most recent developments. Nanobiotechnology indeed appears capable of yielding a scientific and industrial revolution along the routes correctly foreseen by the numerous programs on Nanotechnology launched over the last decade by numerous Councils and Governments worldwide, beginning in the late 1995 by the Science and Technology Council in Italy and by the President Clinton in USA and ending this year with President Putin in Russian Federation.

Proteomics for Biological Discovery
Proteomics for Biological Discovery

Author: Timothy D. Veenstra

Publisher: John Wiley & Sons

Published: 2006-06-12

Total Pages: 361

ISBN-13: 0470007737

DOWNLOAD EBOOK

Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics. Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Accessible to the novice while providing experienced investigators essential information Proteomics for Biological Discovery is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics.

Guide to Yeast Genetics: Functional Genomics, Proteomics, and Other Systems Analysis
Guide to Yeast Genetics: Functional Genomics, Proteomics, and Other Systems Analysis

Author:

Publisher: Academic Press

Published: 2010-02-27

Total Pages: 961

ISBN-13: 012375173X

DOWNLOAD EBOOK

This fully updated edition of the bestselling three-part Methods in Enzymology series, Guide to Yeast Genetics and Molecular Cell Biology is specifically designed to meet the needs of graduate students, postdoctoral students, and researchers by providing all the up-to-date methods necessary to study genes in yeast. Procedures are included that enable newcomers to set up a yeast laboratory and to master basic manipulations. This volume serves as an essential reference for any beginning or experienced researcher in the field. - Provides up-to-date methods necessary to study genes in yeast - Includes proceedures that enable newcomers to set up a yeast laboratory and to master basic manipulations - Serves as an essential reference for any beginning or experienced researcher in the field

Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods
Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods

Author: Debasis Bagchi

Publisher: John Wiley & Sons

Published: 2015-10-12

Total Pages: 685

ISBN-13: 1118930428

DOWNLOAD EBOOK

Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals. A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.

Proteome Research
Proteome Research

Author: Marc R. Wilkins

Publisher: Springer Science & Business Media

Published: 1997

Total Pages: 270

ISBN-13: 9783540627531

DOWNLOAD EBOOK

Introduction to the proteome (K. L. Williams, D. F. Hochstrasser). Two-dimensional electrophoresis: the state of the art and future directions (B. R. Herbert, J.-C. Sanchez, L. Bini). large-scale comparative protein modeling ( M. C. Peitsch, N. Guex); Clinical and biomedical applications of proteomics (D. F. Hochstrasser). Biological applications of proteomics (K. L. Williams, V. Pallini). Conclusions (D. F. Hochstrasser, L. Williams). Index.

Posttranslational Modification of Proteins
Posttranslational Modification of Proteins

Author: Christoph Kannicht

Publisher: Humana Press

Published: 2002-04-16

Total Pages: 322

ISBN-13: 9780896036789

DOWNLOAD EBOOK

Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the posttranslational modifications of protein, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins. Among the methods presented are those for analyzing the assignment of disulfide bond sites in proteins, protein N-glycosylation and protein O-glycosylation, and oligosaccharides present at specific single glycosylation sites in a protein. Additional powerful techniques facilitate the analysis of glycosylphosphatidylinositols, lipid modifications, protein phosphorylation and sulfation, protein methylation and acetylation, a-amidation, g-glutamate, isoaspartate, and lysine hydroxylation.

Genomics and Proteomics
Genomics and Proteomics

Author: Sándor Suhai

Publisher: Springer Science & Business Media

Published: 2007-05-08

Total Pages: 246

ISBN-13: 0306468239

DOWNLOAD EBOOK

Genome research will certainly be one of the most important and exciting sci- tific disciplines of the 21st century. Deciphering the structure of the human genome, as well as that of several model organisms, is the key to our understanding how genes fu- tion in health and disease. With the combined development of innovativetools, resources, scientific know-how, and an overall functional genomic strategy, the origins of human and other organisms’geneticdiseases can be traced. Scientificresearch groups and dev- opmental departments of several major pharmaceutical and biotechnological companies are using new, innovative strategies to unravel how genes function, elucidating the gene protein product, understanding how genes interact with others-both in health and in the disease state. Presently, the impact of the applications of genome research on our society in medicine, agriculture and nutrition will be comparable only to that of communication technologies. In fact, computational methods, including networking, have been playing a substantial role even in genomics and proteomics from the beginning. We can observe, however, a fundamental change of the paradigm in life sciences these days: research focused until now mostly on the study of single processes related to a few genes or gene products, but due to technical developments of the last years we can now potentially identify and analyze all genes and gene products of an organism and clarify their role in the network of lifeprocesses.