Author is a renowned writer in international climbing community Fascinating story of hoax that inspired a quest for a North American Shangri-La Vivid recounting of fabled mountains from across the world Using an infamous deception about a fake mountain range in British Columbia as her jumping-off point, Katie Ives, the well-known editor of Alpinist, explores the lure of blank spaces on the map and the value of the imagination. In Imaginary Peaks she details the cartographical mystery of the Riesenstein Hoax within the larger context of climbing history and the seemingly endless quest for newly discovered peaks and claims of first ascents. Imaginary Peaks is an evocative, thought-provoking tale, immersed in the literature of exploration, study of maps, and basic human desire.
In this tender, funny, and sharp companion to her acclaimed memoir-in-essays Amateur Hour, Kimberly Harrington explores and confronts marriage, divorce, and the ways love, loss, and longing shape a life. Six weeks after Kimberly and her husband announced their divorce, she began work on a book that she thought would only be about divorce — heavy on the dark humor with a light coating of anger and annoyance. After all, on the heels of planning to dissolve a twenty-year marriage they had chosen to still live together in the same house with their kids. Throw in a global pandemic and her idea of what the end of a marriage should look and feel like was flipped even further on its head. This originally dark and caustic exploration turned into a more empathetic exercise, as she worked to understand what this relationship meant and why marriage matters so much. Over the course of two years of what was supposed to be a temporary period of transition, she sifted through her past—how she formed her ideas about relationships, sex, marriage, and divorce. And she dug back into the history of her marriage — how she and her future ex-husband had met, what it felt like to be madly in love, how they had changed over time, the impact having children had on their relationship, and what they still owed one another. But You Seemed So Happy is a time capsule of sorts. It’s about getting older and repeatedly dying on the hill of being wiser, only to discover you were never all that dumb to begin with. It’s an honest, intimate biography of a marriage, from its heady, idealistic, and easy beginnings to it slowly coming apart and finally to its evolution into something completely unexpected. As she probes what it means when everyone assumes you’re happy as long as you’re still married, Harrington skewers engagement photos, Gen X singularity, small-town busybodies, and the casual way we make life-altering decisions when we’re young. Ultimately, this moving and funny memoir in essays is a vulnerable and irreverent act of forgiveness—of ourselves, our partners, and the relationships that have run their course but will always hold profound and permanent meaning in our lives.
Starting middle school brings all the usual challenges — until the unthinkable happens, and Fern and her family must find a way to heal. Twelve-year-old Fern feels invisible. It seems as though everyone in her family has better things to do than pay attention to her: Mom (when she’s not meditating) helps Dad run the family restaurant; Sarah is taking a gap year after high school; and Holden pretends that Mom and Dad and everyone else doesn’t know he’s gay, even as he fends off bullies at school. Then there’s Charlie: three years old, a “surprise” baby, the center of everyone’s world. He’s devoted to Fern, but he’s annoying, too, always getting his way, always dirty, always commanding attention. If it wasn’t for Ran, Fern’s calm and positive best friend, there’d be nowhere to turn. Ran’s mantra, “All will be well,” is soothing in a way that nothing else seems to be. And when Ran says it, Fern can almost believe it’s true. But then tragedy strikes- and Fern feels not only more alone than ever, but also responsible for the accident that has wrenched her family apart. All will not be well. Or at least all will never be the same.
Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.
Overcome the toughest clinical challenges in nephrology with the new 9th edition of Brenner/Rector’s The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Alan S. L. Yu, and Barry M. Brenner,, together with a diverse list of international contributors bring you the latest knowledge and best practices on every front in nephrology worldwide. Brand-new sections on Global Considerations in Nephrology and Pediatric Nephrology, as well as new chapters on recent clinical trials, cardiovascular and renal risk prediction in chronic kidney disease, identification of genetic causes of kidney disease, and many others, keep you at the forefront of this rapidly growing, ever-changing specialty. Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices. Broaden your knowledge base with expert, dependable, comprehensive answers for every stage of your career from the most comprehensive, definitive clinical reference in the field! Prepare for certification or recertification with a review of the basic science that underpins clinical nephrology as well as a comprehensive selection of the most important bibliographical sources in nephrology. Visually grasp and better understand critical information with the aid of over 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making. Get internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors, all of whom are at the top and the cutting edge of your field. A new editorial team headed by Dr. Taal and hand-picked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. Access information quickly thanks to a new, reorganized format and supplemental figures, tables, additional references, and expanded discussions. Keep current with the rapid development of care and research worldwide. A new section, "Global Considerations", focuses on regions outside Europe and North America. Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty. Improve therapy and outcomes for children with renal disease. New to this edition, "Pediatric Nephrology" addresses renal pathologies that usually present in childhood and covers topics such as Maturation of Kidney Structure and Function; Fluid; Electrolyte and Acid-Base Disorders in Children; Diseases of the Kidney and Urinary Tract in Children; Dialysis in Children; and Kidney Transplantation in Children. Stay up to date with all the latest clinical information including recent clinical trials, genetic causes of kidney disease, and cardiovascular and renal risk prediction in chronic kidney disease.
The Urinary System, 2nd Edition provides a concise and highly visual approach to the basic sciences and clinical pathology of the kidney, bladder, and ureters. This volume in The Netter Collection of Medical Illustrations (the CIBA "Green Books") has been expanded and revised by Drs. Christopher Rehbeck Kelly and Jaime Landman to capture current clinical perspectives in nephrology and urology - from normal anatomy, histology, physiology, and development to glomerular and tubular diseases, infections, urological surgeries, and cancers. It also features hundreds of radiologic and pathologic images to supplement the classic Netter illustrations, as well as new illustrations created - Get complete, integrated visual guidance on the kidney, ureters, and bladder in a single source, from basic sciences and normal anatomy and function through pathologic conditions. - Adeptly navigate current controversies and timely topics in clinical medicine with guidance from expert editors, authors, and the input of an international advisory board. - Gain a rich, comprehensive clinical view of the urinary system by seeing classic Netter anatomic illustrations side by side with cutting-edge radiologic images, pathology slides, and the latest molecular biology findings. - Visualize the timely topics in nephrology and urology, including HIV-associated nephropathy, hepatorenal syndrome, laparoscopic and robotic surgeries, and tumor cryoblation. - See current clinical concepts captured in the visually rich Netter artistic tradition via contributions from Carlos Machado, MD, and other artists working in the Netter style.
