Textbook Of Structural Biology (Second Edition)
Textbook Of Structural Biology (Second Edition)

Author: Anders Liljas

Publisher: World Scientific

Published: 2016-09-27

Total Pages: 610

ISBN-13: 9813142499

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This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures.

Architects of Structural Biology
Architects of Structural Biology

Author: John Meurig Thomas

Publisher: Oxford University Press

Published: 2020-02-28

Total Pages: 320

ISBN-13: 0192596713

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Architects of Structural Biology is an amalgam of memoirs, biography, and intellectual history of the personalities and single-minded devotion of four scientists who are among the greatest in modern times. These three chemists and one physicist, all Nobel laureates, played a pivotal role in the creation of a new and pervasive branch of biology. This led in turn to major developments in medicine and to the treatment of diseases as a result of advances made in arguably one of the greatest centres of scientific research ever: the Laboratory of Molecular Biology in Cambridge, which they helped to establish. Their work and that of their predecessors at the Royal Institution in London reflects the broader cultural, scientific and educational strength of the UK from the early 19th century onwards. The book also illustrates the nurturing of academic life in the collegiate system, exemplified by the activities of, and cross-fertilization within, a small Cambridge college.

Albemarle Street: Portraits, Personalities and Presentations at The Royal Institution
Albemarle Street: Portraits, Personalities and Presentations at The Royal Institution

Author: John Meurig Thomas

Publisher: Oxford University Press

Published: 2021-09-23

Total Pages: 300

ISBN-13: 0192652842

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The Royal Institution of Great Britain is renowned the world over, first, because it is a premier arena for the advancement of new scientific and technological knowledge; and second because it highlights the advance of knowledge of all kinds. It bridges the sciences and the humanities, and as much publicity is given to advances in the arts, archaeology, architecture, drama and literature as to the pure and applied sciences. More famous scientists have lived and worked in the Royal Institution than in any other laboratory in the world. A roll-call includes Rumford, Davy, Faraday, Tyndall, Dewar, Rayleigh, W. H. Bragg, W. L. Bragg and George Porter. Not is it only the home of continuous electricity, it is also the birthplace of many aspects of molecular biology and viruses and enzymology. Some fifteen scientists who have won the Nobel Prize have, at one time or another, worked or lectured at the RI. And eminent individuals, like Howard Carter and Coleridge, have lectured there. Albemarle Street - Portraits, Personalities and Presentations at The Royal institution is a lively and compelling personal selection of the remarkable personalities and achievements of some of the extraordinary scientists and individuals who, during the nineteenth and twentieth centuries, worked or lectured at 21 Albemarle Street in Mayfair, central London. John Meurig Thomas offers a unique and valuable insight into the history of this prestigious address, having himself lived and worked at the Royal Institution for some twenty years.

Structural Insights Into Gene Expression And Protein Synthesis
Structural Insights Into Gene Expression And Protein Synthesis

Author: Thomas A Steitz

Publisher: World Scientific

Published: 2020-08-18

Total Pages: 640

ISBN-13: 9811215871

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Several years ago, Thomas Steitz agreed to contribute a volume to the 'World Scientific Series in Structural Biology' that would deal with the contributions he and his coworkers have made to structural biology during his remarkable career. Sadly, Tom died in the fall of 2018 before he had had time to do more than produce an outline for this book, and a list of the reprints he wanted it to contain.Fortunately, Tom's colleagues and coworkers responded enthusiastically when they were informed later that fall that if they were willing to help out, a volume would be published to commemorate his career. It fell to Anders Liljas, Peggy Eatherton, Tom's longtime administrative assistant, and Peter Moore, a close colleague, to oversee their efforts. Thomas Steitz is best known for the work he and his coworkers did to elucidate the biochemical basis of gene expression. The structures of a large number of the macromolecules involved in transcription and translation emerged from his laboratory over the course of his career. This book includes reprints of the most important papers he had published, grouped according to the structures they relate to, and commentaries written by the scientists who collaborated with him to solve each of them. It thus summarizes the achievements of one of the most distinguished biochemists of the second half of the 20th century.

Curiosity And Passion For Science And Art
Curiosity And Passion For Science And Art

Author: Uwe B Sleytr

Publisher: World Scientific

Published: 2016-07-04

Total Pages: 497

ISBN-13: 9813141832

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This book describes the accomplishments of a curious and imaginative scientist, and his endeavours to translate or even to extrapolate scientific insights into the world of art.The science section in this volume concerns studies on S-layers, a very important class of proteins found on the surface of numerous Bacteria and nearly all Archaea. S-layer proteins are one of the most abundant biopolymers on our planet, and assemble into the simplest type of biological membrane. Moreover, they are unique building blocks and patterning elements for the production of complex supramolecular structures and nanoscale devices in nanobiotechnology, molecular nanotechnology, synthetic biology, biomimetics and nanomedicine.In the second part of this book the author goes on to passionately describe how his scientific activities stimulated his art work, which in particular concerns the visualization of results and the potential of synthetic biology and evolutionary events induced by genetic manipulations. Most importantly, the engagement in art allowed him to leave the rather curtailed canon of science and reach a mental state of unlimited freedom of thoughts. Mask-like sculptures are used as examples to visualize the intersection between science and art, and in particular the unpredictability and mystery of scientific visions.

Nobel Prizes And Notable Discoveries
Nobel Prizes And Notable Discoveries

Author: Erling Norrby

Publisher: World Scientific

Published: 2016-09-06

Total Pages: 580

ISBN-13: 9813144661

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The present book discusses the prizes in physiology or medicine 1963-65. The 1963 prize recognized milestone discoveries in the field of neurosciences, the way electrical impulses are generated and spread in nerves. The impressive developments of insights into tantalizing brain functions, like consciousness and memory, is discussed in the perspective of prizes both before and after the 1963 prize. The prize in 1964 marked the advanced biochemical venture that led to a full understanding of the synthesis of cholesterol, a central molecule for providing flexibility of the membranes of the trillions of cell in our body. The importance of this molecule for the appearance of cardiovascular diseases and the possibilities to prevent them is presented in the light of other prizes earlier and later in this field. The 1965 prize recognized three impressive French intellectuals, Lwoff, Monod and Jacob. Their contributions allowed the full maturation of the initial phase of the emerging field of molecular biology. The comprehension of the information flow from DNA via RNA to proteins was the source of a revolution of life sciences and of medicine.

Caught By Viruses
Caught By Viruses

Author: Michael G Rossmann

Publisher: World Scientific

Published: 2021-11-10

Total Pages: 304

ISBN-13: 9811246211

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The current book attempts to give a glimpse of the scientific life of Michael Rossmann. The book begins with his very interesting and moving autobiography. His enormous energy must have been evident already from early childhood when he and his mother had to emigrate from Nazi-Germany to England, via The Netherlands. Starting school with a new language was a challenge that he managed well with the assistance of understanding teachers. Crystallography soon became the tool to explore new worlds, unknown to everybody. With a skill for mathematics, he realized that the transform of a molecular structure in the diffraction pattern could be used for analysis of both symmetry and structural relationships. This method, molecular replacement (MR, also the initials of his name) became one of his great successes of his career. The previous book by him in this series (Selected Papers by Michael G Rossmann with Commentaries) covers his main contributions in this area.With an interest in symmetry, viruses became obvious objects to study. Rossmann attacked these monstrously large molecular assemblies with his unfailing energy and his appetite for real challenges. The amazing variation of molecular arrangements with icosahedral symmetry is truly amazing. This book includes a selection of reports of the structures of some giant viruses. As always, knowing the structure enhances the understanding of function greatly, in the case of viruses the mechanism of infection is a key problem. Rossmann has contributed many central insights in this area.Thus, this book is of interest both as an interesting personal story but also for research into viruses that repeatedly plague all living organisms on the planet, right now in the form of the corona virus pandemic.

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell
Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Author: Lila M Gierasch

Publisher: World Scientific

Published: 2016-08-08

Total Pages: 328

ISBN-13: 9814749346

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This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a 'clamp' or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

From a Grain of Salt to the Ribosome
From a Grain of Salt to the Ribosome

Author: Ivar Olovsson

Publisher: World Scientific Publishing Company

Published: 2015

Total Pages: 0

ISBN-13: 9789814623117

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This book is published to celebrate the International Year of Crystallography 2014, as proclaimed by the United Nations. The year has been chosen as the International Year of Crystallography since it was 100 years ago that the first Nobel Prize was awarded for crystallographic observations to Max von Laue. Just a year later, Sir William Henry Bragg and William Lawrence Bragg, father and son, won their prize for showing the possibility of determining atomic positions in crystals. This book describes the lives and works of 33 Nobel Laureates starting with Wilhelm Conrad Röntgen (1901) and ending with Brian Kobilka (2012). It also reproduces the most important works of these scientists. The book gives a historical perspective of a scientific field that is important for our understanding of the atomic organization of the world around us, from inorganic materials to complex biological molecules, such as the ribosome. This book is a timely summary of the main developments in crystallography over the last 100 years. The central publications of 33 Nobel laureates are reproduced. There is no other book providing this selection of material.

Molecular Evolutionary Genetics
Molecular Evolutionary Genetics

Author: Ross J. MacIntyre

Publisher: Springer

Published: 1985-12-31

Total Pages: 640

ISBN-13:

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This volume in the Monographs in Evolutionary Biology series addresses issues that are part of an emerging area of research loosely called "mo lecular evolution. " Its practitioners include both molecular biologists cu rious about the evolutionary implications of their data and evolutionary biologists pushing their analyses to the molecular level. The union of these fields of molecular and organismal biology has been turbulent at times, and, as shall be seen, this dialectic has led to some very serious challenges to long-held notions about the role of natural selection in evolution and the economy of genome organization in eukaryotes. As an inevitable outgrowth of molecular biology, molecular evolution is necessarily a young discipline, but it can already point proudly to two major discoveries. The first, is the molecular clock, a concept that has emerged from the analysis of at least four data sets-amino acid sequences, immunologic data, DNA renaturation studies, and, recently, analyses of DNA sequences. The reality of a strong stochastic component in the evolution of nucleotide sequences can no longer be doubted, although the accuracy of the clock with regard to particular sequences and within particular groups of or ganisms should be independently measured each time it is used. Never theless, molecular clocks will assume increasingly important roles in phy logenetic reconstructions, especially since the fossil record is so fragmentary. The second major discovery of molecular evolution has been the incredible complexity of the eukaryotic genome.