Fourth Generation Biologics: Molecular Virus Killers

Fourth Generation Biologics: Molecular Virus Killers

Author: Lane B. Scheiber II MD

Publisher: iUniverse

Published: 2014-09-11

Total Pages: 262

ISBN-13: 1491744553

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The world is under constant threat of a virus evolving into a global plague.To this point, there is no direct defense against a widespread viral infection. Fourth Generation Biologics: Molecular Virus Killers offers an innovative, new strategy to combat deadly viral infections. Presented is the discovery of unique identifiers for the viral scourges: HIV, Herpes Simplex, the Shingles virus, the Smallpox virus and the newly emerging threats of Ebola virus and the Chikungunya virus. Analysis of the transcription and translation mechanisms utilized by cells leads to exploring the function of nuclear signaling proteins as intracellular hunter-killer molecules aimed specifically at viral genomes. Utilizing amino acid-to-nucleotide binding characteristics, taking into account Watson-Crick binding, Hoogsteen grove binding, and Vander Waals forces, modifications to existing transcription factors binding sites is undertaken. Transcription factors are altered to specifically target the unique identifier of pathogenic viruses. Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cells cytoplasm as RNA. This emerging technology is then extrapolated to explore activating therapeutic nuclear genes to treat challenging medical conditions including diabetes and osteoarthritis.


Dna Vaccines

Dna Vaccines

Author: Lane Scheiber

Publisher: iUniverse

Published: 2017-07-31

Total Pages: 308

ISBN-13: 1532017227

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The world is under constant threat of a virus evolving into a global plague. To this point, there is no direct defense against a widespread viral infection. DNA Vaccines: Design of a Gene to Eradicate HIV offers an innovative and new strategy to combat deadly viral infections. Presented is the discovery of a unique identifier for HIV. Analysis of the transcription and translation mechanisms utilized by cells leads to exploring the function of nuclear transcription factor proteins as intracellular hunter-killer molecules aimed specifically at viral genomes. Utilizing amino acid-to-nucleotide binding characteristics, taking into account Watson-Crick binding, Hoogsteen grove binding, and Vander Waals forces, modifications to existing transcription factors binding sites are undertaken. Transcription factors are altered to specifically target the unique identifier of pathogenic viruses. Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cells cytoplasm as RNA. This text describes the design of an intracellular courier gene technology to make cells defensible against HIV and other lethal pathogenic viral threats.


Cure and Vaccine, Striking Back at Covid-19

Cure and Vaccine, Striking Back at Covid-19

Author: Lane B. Scheiber II MD

Publisher: iUniverse

Published: 2020-10-01

Total Pages: 198

ISBN-13: 1663208409

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The world is on fire, threatened by a global pandemic brought on by COVID-19. This virulent viral pathogen has rapidly infected every continent across the globe and has spread misery and death in its wake. COVID-19 is very efficient, carrying in its genetic code the instructions to construct its own personal replication machinery. This virus is very effective at copying itself, but does so with a relatively high rate of mutation to the genetic code. Given Coronavirus exhibits a frequent rate of alteration to its state, resulting in an elusive adversary, which makes treating with traditional vaccines an ongoing challenge. Fighting back with novel mRNA therapies, which can be rapidly redesigned, may offer an effective broad-spectrum therapeutic armamentarium to combat Coronavirus. Modification of the native human CD8 cell surface receptor to alert the immune system to the possible presence of the COVID-19, can result in early development of antibodies to target the pathogen. But taking the fight directly to the virus, to stop the infection in an afflicted person, is the next necessary technologic leap in pharmaceutical medicine. Redesigning native human transcription factors to create a hunter-killer protein to neutralize the COVID-19 genome is the next critical innovation necessary to eradicate viral pandemics. Cultivating a cure to counteract viral infections such as Coronavirus is now more essential than ever. Ebola, a devastatingly hostile viral infection, sits lurking, in wait. At the point Ebola evolves into an airborne viral entity, the consequences of such a noxious global pandemic will be horrific. The time is now, to secure versatile and effective vaccines and devise an effective cure to stop rampant viral infections, such as Coronavirus and Ebola.


Human Herpesviruses

Human Herpesviruses

Author: Ann Arvin

Publisher: Cambridge University Press

Published: 2007-08-16

Total Pages: 1325

ISBN-13: 1139461648

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This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.


Theory of Quadsitron-Energy Connectivity

Theory of Quadsitron-Energy Connectivity

Author: Lane B. Scheiber II MD

Publisher: iUniverse

Published: 2019-05-23

Total Pages: 361

ISBN-13: 1532071507

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The luminous aether, a concept known for hundreds of years, is the fine essence of the universe. Over the last 130 years, mainstream science abandoned the knowledge such an aether existed. Yet, reawakening the principles of a luminous aether as the fabric of space--both within our being and surrounding us, reaching out in every direction to the very edges of the universe-- explains many unsolved mysteries. The luminous aether is a vast three-dimensional ocean of the tiniest and most elemental particles called quadsitrons. From the fusion of quadsitrons and energy, all else in the universe is constructed. The dynamics of quadsitrons interacting with energy accounts for and connects all the micro and macrophenomena that fill our lives, such as gravity, light, electrons, atoms, molecules, and magnetism. It is essential we understand and grasp the principles of this wondrous quadsitron-energy connectivity in order to advance our technology forward to interstellar travel.


Defense Against Biological Attacks

Defense Against Biological Attacks

Author: Sunit K. Singh

Publisher: Springer

Published: 2019-05-02

Total Pages: 388

ISBN-13: 3030030717

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This second volume of a two-volume set focuses on specific pathogens and their mechanisms of pathogenesis as well as diagnostics, therapeutics and various strategies in the event of biological attacks. This multidisciplinary book appeals to readers from various fields, including biodefense, biosafety & biosecurity, virology, neurology, molecular biology and genetic engineering, as well as infectious disease specialists. Further, the work is of interest to basic science and applied science research scholars and experts working in the area of high-consequence or select agent virology.


The Epstein-Barr Virus

The Epstein-Barr Virus

Author: M. A. Epstein

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 467

ISBN-13: 3642672361

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The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.


Molecular Biology of the Biological Control of Pests and Diseases of Plants

Molecular Biology of the Biological Control of Pests and Diseases of Plants

Author: Muthukumaran Gunasekaran

Publisher: CRC Press

Published: 2020-01-29

Total Pages: 234

ISBN-13: 1000721914

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While many books are available on biological control, this is the only book to detail the application of molecular biology to control of pests and diseases. Each chapter deals with a different pathogen and the application of new molecular biological techniques to the biocontrol of the pathogen. This new reference presents the most comprehensive list of organisms available. Internationally respected experts discuss viruses, bacteria, fungi, nematodes, protozoa, weeds, and insects. Types of control methods are described, and techniques commonly used in molecular biology to identify the etiological agents, diagnose diseases, and develop control methods are reviewed.


Microbial Protein Toxins

Microbial Protein Toxins

Author: Manfred Schmitt

Publisher: Springer Science & Business Media

Published: 2004-12-10

Total Pages: 264

ISBN-13: 9783540235620

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Since the initial establishment of Robert Koch’s postulates in the nineteenth century, microbial protein toxins have been recognized as a major factor of bacterial and fungal virulence. An increasing number of proteins produced and secreted by various bacteria, yeasts and plants are extremely toxic and most of them developed remarkably "intelligent" strategies to enter, to penetrate and to finally kill a eukaryotic target cell by modifying or blocking essential cellular components. This book describes the strategies employed by protein toxins to render their pro- and eukaryotic producers a selective growth advantage over competitors. In providing an up-to-date overview on the mode of protein toxin actions, it accommodates biomedically and biologically relevant toxin model systems. As a result, it significantly broadens our perspective on biochemical architecture and molecular ploy behind the lethal principles of pro- and eukaryotic toxins.