Survival Analysis with Correlated Endpoints
Survival Analysis with Correlated Endpoints

Author: Takeshi Emura

Publisher: Springer

Published: 2019-03-25

Total Pages: 126

ISBN-13: 9811335168

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This book introduces readers to advanced statistical methods for analyzing survival data involving correlated endpoints. In particular, it describes statistical methods for applying Cox regression to two correlated endpoints by accounting for dependence between the endpoints with the aid of copulas. The practical advantages of employing copula-based models in medical research are explained on the basis of case studies. In addition, the book focuses on clustered survival data, especially data arising from meta-analysis and multicenter analysis. Consequently, the statistical approaches presented here employ a frailty term for heterogeneity modeling. This brings the joint frailty-copula model, which incorporates a frailty term and a copula, into a statistical model. The book also discusses advanced techniques for dealing with high-dimensional gene expressions and developing personalized dynamic prediction tools under the joint frailty-copula model. To help readers apply the statistical methods to real-world data, the book provides case studies using the authors’ original R software package (freely available in CRAN). The emphasis is on clinical survival data, involving time-to-tumor progression and overall survival, collected on cancer patients. Hence, the book offers an essential reference guide for medical statisticians and provides researchers with advanced, innovative statistical tools. The book also provides a concise introduction to basic multivariate survival models.

Flexible Parametric Survival Analysis Using Stata
Flexible Parametric Survival Analysis Using Stata

Author: Patrick Royston

Publisher: Stata Press

Published: 2011-08-04

Total Pages: 0

ISBN-13: 9781597180795

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Through real-world case studies, this book shows how to use Stata to estimate a class of flexible parametric survival models. It discusses the modeling of time-dependent and continuous covariates and looks at how relative survival can be used to measure mortality associated with a particular disease when the cause of death has not been recorded. The book describes simple quantification of differences between any two covariate patterns through calculation of time-dependent hazard ratios, hazard differences, and survival differences.

Survival Analysis with Interval-Censored Data
Survival Analysis with Interval-Censored Data

Author: Kris Bogaerts

Publisher: CRC Press

Published: 2017-11-20

Total Pages: 537

ISBN-13: 1351643053

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Survival Analysis with Interval-Censored Data: A Practical Approach with Examples in R, SAS, and BUGS provides the reader with a practical introduction into the analysis of interval-censored survival times. Although many theoretical developments have appeared in the last fifty years, interval censoring is often ignored in practice. Many are unaware of the impact of inappropriately dealing with interval censoring. In addition, the necessary software is at times difficult to trace. This book fills in the gap between theory and practice. Features: -Provides an overview of frequentist as well as Bayesian methods. -Include a focus on practical aspects and applications. -Extensively illustrates the methods with examples using R, SAS, and BUGS. Full programs are available on a supplementary website. The authors: Kris Bogaerts is project manager at I-BioStat, KU Leuven. He received his PhD in science (statistics) at KU Leuven on the analysis of interval-censored data. He has gained expertise in a great variety of statistical topics with a focus on the design and analysis of clinical trials. Arnošt Komárek is associate professor of statistics at Charles University, Prague. His subject area of expertise covers mainly survival analysis with the emphasis on interval-censored data and classification based on longitudinal data. He is past chair of the Statistical Modelling Society and editor of Statistical Modelling: An International Journal. Emmanuel Lesaffre is professor of biostatistics at I-BioStat, KU Leuven. His research interests include Bayesian methods, longitudinal data analysis, statistical modelling, analysis of dental data, interval-censored data, misclassification issues, and clinical trials. He is the founding chair of the Statistical Modelling Society, past-president of the International Society for Clinical Biostatistics, and fellow of ISI and ASA.

On Human Nature
On Human Nature

Author: Jonathan H. Turner

Publisher: Routledge

Published: 2020-11-24

Total Pages: 234

ISBN-13: 1000213757

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In this book, Jonathan H. Turner combines sociology, evolutionary biology, cladistic analysis from biology, and comparative neuroanatomy to examine human nature as inherited from common ancestors shared by humans and present-day great apes. Selection pressures altered this inherited legacy for the ancestors of humans—termed hominins for being bipedal—and forced greater organization than extant great apes when the hominins moved into open-country terrestrial habitats. The effects of these selection pressures increased hominin ancestors’ emotional capacities through greater social and group orientation. This shift, in turn, enabled further selection for a larger brain, articulated speech, and culture along the human line. Turner elaborates human nature as a series of overlapping complexes that are the outcome of the inherited legacy of great apes being fed through the transforming effects of a larger brain, speech, and culture. These complexes, he shows, can be understood as the cognitive complex, the psychological complex, the emotions complex, the interaction complex, and the community complex.

Bayesian Precision Medicine
Bayesian Precision Medicine

Author: Peter F. Thall

Publisher: CRC Press

Published: 2024-05-07

Total Pages: 711

ISBN-13: 1040026710

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Bayesian Precision Medicine presents modern Bayesian statistical models and methods for identifying treatments tailored to individual patients using their prognostic variables and predictive biomarkers. The process of evaluating and comparing treatments is explained and illustrated by practical examples, followed by a discussion of causal analysis and its relationship to statistical inference. A wide array of modern Bayesian clinical trial designs are presented, including applications to many oncology trials. The later chapters describe Bayesian nonparametric regression analyses of datasets arising from multistage chemotherapy for acute leukemia, allogeneic stem cell transplantation, and targeted agents for treating advanced breast cancer. Features: Describes the connection between causal analysis and statistical inference Reviews modern personalized Bayesian clinical trial designs for dose-finding, treatment screening, basket trials, enrichment, incorporating historical data, and confirmatory treatment comparison, illustrated by real-world applications Presents adaptive methods for clustering similar patient subgroups to improve efficiency Describes Bayesian nonparametric regression analyses of real-world datasets from oncology Provides pointers to software for implementation Bayesian Precision Medicine is primarily aimed at biostatisticians and medical researchers who desire to apply modern Bayesian methods to their own clinical trials and data analyses. It also might be used to teach a special topics course on precision medicine using a Bayesian approach to postgraduate biostatistics students. The main goal of the book is to show how Bayesian thinking can provide a practical scientific basis for tailoring treatments to individual patients.

Economic Anthropology
Economic Anthropology

Author: Chris Hann

Publisher: John Wiley & Sons

Published: 2018-06-11

Total Pages: 161

ISBN-13: 0745699391

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This book is a new introduction to the history and practice of economic anthropology by two leading authors in the field. They show that anthropologists have contributed to understanding the three great questions of modern economic history: development, socialism and one-world capitalism. In doing so, they connect economic anthropology to its roots in Western philosophy, social theory and world history. Up to the Second World War anthropologists tried and failed to interest economists in their exotic findings. They then launched a vigorous debate over whether an approach taken from economics was appropriate to the study of non-industrial economies. Since the 1970s, they have developed a critique of capitalism based on studying it at home as well as abroad. The authors aim to rejuvenate economic anthropology as a humanistic project at a time when the global financial crisis has undermined confidence in free market economics. They argue for the continued relevance of predecessors such as Marcel Mauss and Karl Polanyi, while offering an incisive review of recent work in this field. Economic Anthropology is an excellent introduction for social science students at all levels, and it presents general readers with a challenging perspective on the world economy today. Selected by Choice as a 2013 Outstanding Academic Title

People of the Earth
People of the Earth

Author: Brian M. Fagan

Publisher: Routledge

Published: 2015-08-26

Total Pages: 559

ISBN-13: 1317346823

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Understand major developments of human prehistory People of the Earth: An Introduction to World Prehistory 14/e, provides an exciting journey though the 7-million-year-old panorama of humankind's past. This internationally renowned text provides the only truly global account of human prehistory from the earliest times through the earliest civilizations. Written in an accessible way for beginning students, People of the Earth shows how today's diverse humanity developed biologically and culturally over millions of years against a background of constant climatic change.

Building the Devil's Empire
Building the Devil's Empire

Author: Shannon Lee Dawdy

Publisher: University of Chicago Press

Published: 2008-09-15

Total Pages: 344

ISBN-13: 0226138437

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Building the Devil’s Empire is the first comprehensive history of New Orleans’s early years, tracing the town’s development from its origins in 1718 to its revolt against Spanish rule in 1768. Shannon Lee Dawdy’s picaresque account of New Orleans’s wild youth features a cast of strong-willed captives, thin-skinned nobles, sharp-tongued women, and carousing travelers. But she also widens her lens to reveal the port city’s global significance, examining its role in the French Empire and the Caribbean, and she concludes that by exemplifying a kind of rogue colonialism—where governments, outlaws, and capitalism become entwined—New Orleans should prompt us to reconsider our notions of how colonialism works. "[A] penetrating study of the colony's founding."—Nation “A brilliant and spirited reinterpretation of the emergence of French New Orleans. Dawdy leads us deep into the daily life of the city, and along the many paths that connected it to France, the North American interior, and the Greater Caribbean. A major contribution to our understanding of the history of the Americas and of the French Atlantic, the work is also a model of interdisciplinary research and analysis, skillfully bringing together archival research, archaeology, and literary analysis.”—Laurent Dubois, Duke University

The Development of Language
The Development of Language

Author: Geoff Williams

Publisher: Bloomsbury Publishing

Published: 2006-03-22

Total Pages: 279

ISBN-13: 1441184589

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This book presents a unique range of interdisciplinary work on questions of language development and evolution. It makes visible the significant contribution which meaning-oriented linguistics is making to debates about the origins of language - from the perspective of language evolution in the species as well as language development in the child. As well as linguistics in the systemic functional, or Hallidayan, tradition, the book offers contributions from primatology, psychiatry, sociology and education.