Fast Facts: Myelofibrosis
Fast Facts: Myelofibrosis

Author: Donal McLornan

Publisher: Karger Medical and Scientific Publishers

Published: 2022-04-25

Total Pages: 102

ISBN-13: 3318070807

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Myelofibrosis is a myeloproliferative neoplasm that has markedly heterogeneous features. The clinical phenotype can range from initial indolent presentation, which may be stable for many years, through to marked cytopenias, debilitating constitutional symptoms, massive splenomegaly and an inherent risk of leukemic transformation. Despite many advances regarding molecular classification, prognostication models and rapeutic options over the last few decades, allogeneic stem cell transplantation remains the only curative option, yet is suitable only for a minority of patients. ‘Fast Facts: Myelofibrosis’ is written for health professionals by two leading experts in the field, and provides up-to-date guidance on its accurate diagnosis, risk stratification and management. It also provides key insights into the molecular biology underpinning the disease. This concise handbook is an indispensable read for anyone wanting to get up to speed with best practice in the diagnosis and care of people with myelofibrosis. Table of Contents: • Presentation, classification and epidemiology • Molecular biology and pathogenesis • Clinical assessment and diagnosis • Prognostic models • Treatment approaches • Allogeneic stem cell transplantation • Management of blast-phase myelofibrosis • Therapies in development

Fast Facts: Myeloproliferative Neoplasms
Fast Facts: Myeloproliferative Neoplasms

Author: Ruben A. Mesa

Publisher: Karger Medical and Scientific Publishers

Published: 2019

Total Pages: 117

ISBN-13: 1910797790

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Presentation of the myeloproliferative neoplasms (MPNs) varies widely, and correct diagnosis and management can be challenging, and is becoming more complex as understanding of the underlying molecular basis for these disorders emerges. Appropriate management is increasingly informed by accurate risk stratification founded on understanding of cytogenetic and molecular markers, as well as the clinical presentation. 'Fast Facts: myeloproliferative neoplasms' focuses on the three most common chronic MPNs: * Essential thrombocythemia (ET) - characterized by increased platelet count * Polycythemia vera (PV) - characterized by excessive production of red blood cells * Primary myelofibrosis - a more severe and heterogenous disorder that may overlap with ET and PV but is commonly associated with anemia. Written by two leading experts in the field, Fast Facts: myeloproliferative neoplasms provides concise, up-to-date and practical guidance on the accurate diagnosis, risk stratification and management of these MPNs. It also provides key insights into our growing understanding of the underlying molecular and genetic basis of these disorders, and how this is informing risk stratification and management strategies. This concise handbook will be invaluable to clinicians, medical students, nurses, pharmacists and scientists in understanding and overcoming the everyday and rarer challenges associated with MPN.

Fast Facts: Myeloproliferative Neoplasms
Fast Facts: Myeloproliferative Neoplasms

Author: R.A. Mesa

Publisher: Karger Medical and Scientific Publishers

Published: 2019-02-11

Total Pages: 117

ISBN-13: 1910797804

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Presentation of the myeloproliferative neoplasms (MPNs) varies widely, and correct diagnosis and management can be challenging, and is becoming more complex as understanding of the underlying molecular basis for these disorders emerges. Appropriate management is increasingly informed by accurate risk stratification founded on understanding of cytogenetic and molecular markers, as well as the clinical presentation. 'Fast Facts: myeloproliferative neoplasms' focuses on the three most common chronic MPNs: • Essential thrombocythemia (ET) – characterized by increased platelet count • Polycythemia vera (PV) – characterized by excessive production of red blood cells • Primary myelofibrosis – a more severe and heterogenous disorder that may overlap with ET and PV but is commonly associated with anemia. Written by two leading experts in the field, Fast Facts: myeloproliferative neoplasms provides concise, up-to-date and practical guidance on the accurate diagnosis, risk stratification and management of these MPNs. It also provides key insights into our growing understanding of the underlying molecular and genetic basis of these disorders, and how this is informing risk stratification and management strategies. This concise handbook will be invaluable to clinicians, medical students, nurses, pharmacists and scientists in understanding and overcoming the everyday and rarer challenges associated with MPN.

Fast Facts: Pyruvate Kinase Deficiency
Fast Facts: Pyruvate Kinase Deficiency

Author: Bertil Glader

Publisher: Karger Medical and Scientific Publishers

Published: 2018-08-27

Total Pages: 66

ISBN-13: 191079788X

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You may be unfamiliar with pyruvate kinase (PK) deficiency. It is a rare inherited enzyme disorder that affects the glycolytic pathway used by red blood cells to generate energy, manifesting as hemolytic anemia. The symptoms vary greatly between individuals, making diagnosis difficult, and management primarily comprises supportive treatments. Written by experts in the field, 'Fast Facts: Pyruvate Kinase Deficiency' provides a comprehensive introduction to the condition, including details of: • the underlying defect • its mode of inheritance, and the relationship between genotype and phenotype • how the condition manifests • the fundamentals of diagnosis and how to differentiate it from a heterogeneous group of hemolytic disorders • monitoring and managing the complications that may arise. 'Fast Facts: Pyruvate Kinase Deficiency' will be of interest to primary care providers, hematologists, oncologists, pediatricians, internal medicine specialists, hematology nurses and medical students; indeed, anyone who wishes to learn more about this rare genetic blood disorder. Contents: • Overview • Epidemiology and etiology • Differential diagnosis • Diagnosis of pyruvate kinase deficiency • Complications and monitoring • Supportive treatment

Ferri's Practical Guide: Fast Facts for Patient Care E-Book
Ferri's Practical Guide: Fast Facts for Patient Care E-Book

Author: Fred F. Ferri

Publisher: Elsevier Health Sciences

Published: 2014-03-28

Total Pages: 457

ISBN-13: 1455744581

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For nearly 25 years, Ferri's concise, pocket-sized resource has served as the go-to reference for practical, clinical information among students, residents, and other medical professionals. Formerly known as Practical Guide to the Care of the Medical Patient, this volume continues to provide a fast, effective, and efficient way to identify the important clinical, laboratory, and diagnostic imaging information you need to get through your internal medicine clerkship or residency. - Consult this title on your favorite device, conduct rapid searches, and adjust font sizes for optimal readability. - Benefit from the expert guidance of Dr. Fred Ferri, a leading teacher, clinician, and author. - Confidently manage patients with the latest clinical information, drug therapies, and lab tests. - Apply the latest knowledge and techniques with this updated and streamlined title, which still stays true to the Ferri name. - Quickly find important information with content organized into three major sections: Section I, titled "Surviving the Wards," contains information on charting, laboratory evaluation and formulary; Section II provides the differential diagnosis of common signs and symptoms likely to be encountered in the acute care setting; Section III has been completely revised and subdivided into 11 specialty specific diseases and disorders. - Carry just the sections you need, add personalized materials, and keep everything together and safe with an improved ring binder and design. - Access the full text and procedural videos online at Expert Consult.

Fast Facts: Bleeding Disorders
Fast Facts: Bleeding Disorders

Author: David Green

Publisher: Karger Medical and Scientific Publishers

Published: 2013-02-25

Total Pages: 150

ISBN-13: 1908541369

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Most hemorrhagic problems are emergencies, requiring rapid diagnosis and prompt management to stop bleeding. In some cases, such as nose bleeds, large bruises and heavy menses, it is the clinician’s responsibility to discern whether the patient has a clinically significant bleeding disorder that may predispose to excessive or potentially serious bleeding. 'Fast Facts: Bleeding Disorders' keeps a complex subject simple and clinically oriented. The authors have made numerous updates to this second edition to ensure it provides essential information in a readily accessible format. Highlights include: • An expert overview of normal hemostasis • A clear assessment pathway, from taking an accurate history and focused clinical examination, to essential laboratory investigations • Objective criteria for diagnosing hereditary hemorrhagic telangiectasia • The latest guidelines on diagnosing and treating primary immune thrombocytopenia • A discussion of the benefits of prophylaxis in patients with hemophilia • Updated methods for evaluating and treating bleeding disorders in pregnancy • An overview of the scoring system for disseminated intravascular coagulation • Information on the latest anticoagulants and antithrombotics, including bleeding risks and strategies to control bleeding. 'Fast Facts: Bleeding Disorders' remains a comprehensive up-to-date reference that reflects the latest research and clinical guidelines. It will assist primary care providers, physician assistants, nurse-clinicians, pharmacists, residents and doctors in training as they confront the challenges of controlling bleeding in patients with hemophilia, von Willebrand disease, platelet disorders and thrombosis, or as a result of antithrombotic or anticoagulant therapy. It is a small book packed with important information, designed to swiftly improve patient treatment and outcomes. Contents: • Normal hemostasis • Assessment of bleeding symptoms • Vascular purpuras • Platelet disorders • Pharmacological hemostatic products • Hemophilia • von Willebrand disease • Uncommon congenital coagulation disorders • Liver and kidney disorders • Pregnancy • Perioperative bleeding • Disseminated intravascular coagulation • Anticoagulants and antithrombotic agents • Useful resources

Fast Facts: Acute Myeloid Leukemia
Fast Facts: Acute Myeloid Leukemia

Author: William Blum

Publisher: Karger Medical and Scientific Publishers

Published: 2018-05-14

Total Pages: 90

ISBN-13: 1910797596

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This last year has seen the approval of the first targeted treatments for acute myeloid leukemia (AML) - following decades with no new developments and a poor prognosis for most patients with the disease. The new drugs reflect the remarkable progress that has been made in our understanding of the pathophysiology of AML and its underlying cytogenetic and molecular abnormalities - which differ not only between patients but also within a patient over time and with treatment. 'Fast Facts: Acute Myeloid Leukemia' provides a comprehensive yet concise foundation for understanding AML: from basic epidemiology, diagnosis, classification and the current 'standard' treatment, through to recent advances in our understanding of the cytogenetic and molecular underpinnings of the disease, such as the IDH2 mutation, and the future for tailored therapy. It will be useful to primary care providers, medical students, specialist nurses, junior doctors and allied healthcare professionals who want to develop a thorough grounding in our evolving understanding of AML and its treatment. Contents: • Epidemiology, pathophysiology and etiology • Diagnosis • Treatment • Supportive care • Prognosis and monitoring • Emerging treatments • Useful resources

Diagnostic Pathology: Molecular Oncology E-Book
Diagnostic Pathology: Molecular Oncology E-Book

Author: Mohammad A. Vasef

Publisher: Elsevier Health Sciences

Published: 2019-08-08

Total Pages: 1014

ISBN-13: 0323611451

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Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies. - Provides updated information on molecular mutations in different tumors, including solid tumors and hematopoietic neoplasms, and new targeted therapies geared toward these molecular alterations - Discusses now widely used immunotherapy treatments, including how immunotherapy has revolutionized the treatment of many neoplasms such as breast and lung carcinomas and lymphoma - Features more than 2,000 annotated images throughout, including H&E stains, immunostains, and FISH images - Covers timely topics such as: - Recent advances in cancer immunotherapy, specifically in the molecular basis of immunotherapy - Newly discovered targeted therapies, including multiple lung carcinoma therapies now considered for patients based on existing mutations to specific genes (KRAS, ALK, BRAF, and ROS) - The need for integration of myeloid and lymphoid gene panels due to increased knowledge from next generation sequencing studies of new mutations and the resulting newly developed molecular targets - Increased usage of next generation sequencing techniques - Changes to hematopoietic tumor details based on revised WHO guidelines - Recipient of a 2016 BMA Award: Highly Commended, Pathology (previous edition)

Hematology in Practice
Hematology in Practice

Author: Betty Ciesla

Publisher: F.A. Davis

Published: 2018-11-23

Total Pages: 878

ISBN-13: 0803698194

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Basic principles of hematology made memorable. Build a solid understanding of hematology in the context of practical laboratory practice and principles. Visual language, innovative case studies, role-playing troubleshooting cases, and laboratory protocols bring laboratory practice to life. Superbly organized, this reader-friendly text breaks a complex subject into easy-to-follow, manageable sections. Begin with the basic principles of hematology; discover red and white blood cell disorders; journey through hemostasis and disorders of coagulation; and then explore the procedures needed in the laboratory.

Berquist's Musculoskeletal Imaging Companion
Berquist's Musculoskeletal Imaging Companion

Author: Jeffrey J. Peterson

Publisher: Lippincott Williams & Wilkins

Published: 2017-11-01

Total Pages: 1184

ISBN-13: 1496381645

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Using a quick-reference, highly illustrated approach, Berquist's Musculoskeletal Imaging Companion, Third Edition, is a practical guide to the radiologic diagnosis of the full range of musculoskeletal disorders. It presents over 1500 large, clear images of common diseases, disorders, and injuries, accompanied by succinct, bulleted "key facts" regarding the clinical and imaging features of each condition. Helpful tables, high-quality line drawings, and suggested readings for further study help you choose the best imaging approach and achieve optimal results for every patient.