Familial Cancer Management addresses familial cancer patterns, a rapidly expanding field of investigation resulting from recent significant advances in molecular genetics. It encompasses etiological and pathological aspects of familial cancer clustering, the description of frequent and important family syndromes, diagnostic procedures, and principles of counseling, prevention, and management. This unique and thorough text also discusses important ethical and legal issues and identifies familial cancer assessment services. Familial Cancer Management is written for health care professionals enabling them to identify and manage familial cancer occurrences.
The most comprehensive guide available on hereditary cancers, from understanding risk, prevention, and genetic counseling and testing to treatment, quality of life, and more. Up to 10 percent of cancers are caused by inherited mutations in specific genes. Finding out that you or your loved ones may be at increased risk of developing cancer because of a genetic mutation raises a lot of questions: Is cancer inevitable? Is there anything I should do differently in my life? Will my children also be at higher risk of cancer? Should I have preemptive treatments or surgery? This comprehensive guide provides answers to these questions and more. Written by three passionate patient advocates, this book is a compilation of the trusted information and support provided for more than two decades by Facing Our Risk of Cancer Empowered (FORCE), the de facto voice of the hereditary cancer community. Combining the latest scientific research with national guidelines, expert advice, and compelling patient stories, the book offers previvors (those who have a mutation but have never been diagnosed), survivors, and their families the guidance they need to face the unique physical and emotional challenges of living in a high-risk body. An ideal resource for genetic counselors, physicians, nurses, advocates, and others who support and care for the hereditary cancer community, Living with Hereditary Cancer Risk also provides coverage of • signs of inherited cancer risk in a family; • the value of genetic counseling and testing; • mutations in BRCA, Lynch Syndrome, and other genes that elevate cancer risk; • risk-reducing strategies; • traditional treatments and newer personalized approaches, including immunotherapies and PARP inhibitors; • nationally recommended guidelines for prevention, early detection, and treatment; • insurance coverage and discrimination protections; and • coping with sexual health, fertility, menopause, and other quality of life issues.
The second edition of Inherited Cancer Syndromes incorporates new genetic markers data with the clinical utility and practicality of the first edition.
The role of genetics is becoming increasingly important in all aspects of healthcare and particularly in the field of cancer care. Genetics for Health Professionals in Cancer Care: From Principles to Practice equips health professionals with the knowledge and skills required for all aspects of managing cancer family history. This includes taking an accurate cancer family history and drawing a family tree; understanding cancer biology, basic cancer genetics and the genes involved in hereditary breast, ovarian, prostate, colorectal, gastric and related gynaecological cancers and rare cancer predisposing syndromes; assessing cancer risk and communicating risk information; early detection and risk reducing measures available for those at increased risk and managing individuals with hereditary cancer. Drawing on experiences of health professionals, Genetics for Health Professionals in Cancer Care discusses the challenges raised and provides practical advice and insight into what happens when a patient is referred for genetic counselling and genetic testing, including the psychological, social and ethical issues faced by individuals and families with and at risk of hereditary cancer. The book also provides practical guidance on setting up a cancer family history clinic in primary and secondary care. Genetics for Health Professionals in Cancer Care is essential reading for healthcare professionals working with cancer patients and their families, and is an ideal reference text for non-specialists working in cancer genetics.
Get a quick, expert overview of the many key facets of pediatric cancer genetics with this concise, practical resource by Dr. Nathaniel H. Robin and Meagan Farmer, MS, CGC, MBA. Ideal for pediatric oncologists and all providers who care for children, this easy-to-read reference addresses the remarkable potential of genetic testing as well as the complexities of choosing the correct test, understanding the results, and counseling the family. Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counselors. Highlights examples of syndromes that present in childhood and increase susceptibility to cancer. Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer. Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples. Consolidates today’s available information and guidance in this timely area into one convenient resource.
A New Strategy Toward Cancer Control. Still in its infancy, the familial/hereditary approach to cancer control is proving to be one of the most potent strategies in the war on cancer. Over the past few years the human genome project has generated an abundance of valuable information on the genetic origins of a range of cancers. Tests now exist for several hereditary, tumor-promoting genetic mutations-including those found in BRCA genes associated with breast cancer as well as mutations of HNPCC genes which have been linked to colon cancers-and many more are anticipated in the near future. Armed with the information yielded by these tests, physicians have already saved countless lives through preventative counseling, early detection, and more highly-focused intervention strategies. Inspired by the proceedings of the UICC 1997 Symposium on Familial Cancer and Prevention held in Kobe, Japan, this volume provides clinicians and researchers with a detailed review of the latest developments at the front lines of the familial cancer prevention movement. In a series of edited contributions, leading researchers and clinicians from around the globe summarize their experiences and analyze current and emerging trends in: * Information gathering and history taking. * Risk assessment. * Genetic testing for colorectal, endocrine, breast, and other familial cancers. * Diagnosis, prognosis, and management of an array of familial cancers. * Genetic counseling for familial cancers. Up-to-date, authoritative, and comprehensive, Familial Cancer and Prevention is an important working resource for clinicians, cancer researchers, and epidemiologists.
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Physicians should have the knowledge derived from morphological findings to identify the likelihood of a cancer patient having an additional underlying familial syndrome— and to decide if that patient should undergo molecular genetic evaluation. This volume is specifically designed to help pathologists, oncologists, and other physicians who diagnose and treat cancer to recognize syndromes and syndrome- associated neoplasms and advise patients and their families on the possibility of a familial syndrome and their risk of developing other tumors. Diagnostic Pathology: Familial Cancer Syndromes, second edition, is an easy-to-use, one-stop reference for information on hereditary cancer syndromes, including differential diagnosis and management, that offers a templated, highly formatted design; concise, bulleted text; and superior color images throughout. Contains all the information necessary to determine whether a neoplasm typically encountered in daily practice is sporadic or related to a familial cancer syndrome Features a revised structure to keep you up to date: Part I includes more than 80 detailed chapters describing diagnoses associated with familial cancer syndromes; Part II contains more than 70 chapters with detailed descriptions of major syndromes (cross-referenced with diagnoses); and Part III features a molecular factors index that includes a complete description of each known gene associated with a familial cancer syndrome Contains updated chapters with newly classified GI, neurology, multiple organ, eye, endocrine, GYN, and kidney tumors, as well as more than 20 entirely new chapters covering recently recognized syndromes Incorporates up-to-date molecular findings and their significance for familial cancer syndromes; new techniques and technologies being used to discover gene mutations and other alterations; and details on personalized medicine targeted to specific genes Features more than 2,200 images throughout, including clinical and radiological images, algorithms, graphics, gross pathology, histology, and a wide range of special and immunohistochemical stains—all carefully annotated to highlight the most diagnostically significant factors Features time-saving bulleted text, key facts in each chapter, an extensive index, and numerous tables for quick reference and thorough understanding
Many hereditary cancer syndromes are linked to alterations in single genes. Detection and clinical interpretation of these alterations can guide cancer risk reduction for patients and their families through screening, prophylactic measures, and other strategies. Diagnosis and Management of Hereditary Cancer summarizes hereditary syndromes and their associated cancers and genes. The information is presented in 50 practice-enhancing tables that relate clinical, genetic, diagnostic, and management aspects in a manner that has previously not been available in a single reference. Intended to guide the specialist as well the novice, this volume will elevate the care of hereditary cancer patients and their families. Unique table-based presentation of 50 key aspects of hereditary cancer Clinical features, genetics, genetic testing, diagnosis, counseling, and management of multiple hereditary cancer syndromes Table-based format to inter-relate clinical and scientific information Landscape layout for easier viewing of tabular information
Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology
