Exotic Nuclei - Exon-2001, Proceedings Of The International Symposium
Exotic Nuclei - Exon-2001, Proceedings Of The International Symposium

Author: Evgeni A Cherepanov

Publisher: World Scientific

Published: 2002-05-15

Total Pages: 767

ISBN-13: 9814488399

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This book is a collection of talks presented at the International Symposium on Exotic Nuclei, held at Lake Baikal, Russia, on 24 - 28 July 2001. The talks were given by the leading scientists in the physics of exotic nuclei.Among the topics of the Symposium were the following: production and study of properties of nuclei in extreme states, strongly deformed nuclei, highly excited nuclei and nuclei far from the line of stability as well as nuclei having large angular momenta.New results of investigations are presented in the book — in particular, the data on new nuclei with proton or neutron haloes, on the changes in the shell structure of nuclei near the drip lines, and on the structure of exotic nuclei, including information on the island of inversion. The latest results on the synthesis of new superheavy elements are also provided, and existing detecting devices and accelerators of exotic nuclei, as well as future projects for the creation of similar set-ups, are presented.

G Protein Coupled Receptors
G Protein Coupled Receptors

Author:

Publisher: Academic Press

Published: 2013-01-17

Total Pages: 451

ISBN-13: 0123918723

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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers G protein coupled receptors - Contains chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain

Genome Evolution
Genome Evolution

Author: Axel Meyer

Publisher: Springer Science & Business Media

Published: 2011-06-28

Total Pages: 242

ISBN-13: 9401002630

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In the years since the publication of Susumu Ohno's 1970 landmark book Evolution by gene duplication tremendous advances have been made in molecular biology and especially in genomics. Studies of genome structure and function prerequisite to testing hypotheses of genome evolution were all but impossible until recent methodological advances. This book evaluates newly generated empirical evidence as it pertains to theories of genomic evolutionary patterns and processes. Tests of hypotheses using analyses of complete genomes, interpreted in a phylogenetic context, provide evidence regarding the relative importance of gene duplication. The alternative explanation is that the evolution of regulatory elements that control the expression of and interactions among genes has been a more important force in shaping evolutionary innovation. This collection of papers will be of interest to all academic and industry researchers working in the fields of molecular biology, biotechnology, genomics and genome centers.

Index Medicus
Index Medicus

Author:

Publisher:

Published: 2002

Total Pages: 1612

ISBN-13:

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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Retinal Degenerations
Retinal Degenerations

Author: Matthew M LaVail

Publisher: Springer Science & Business Media

Published: 2003-10-31

Total Pages: 490

ISBN-13: 9780306477812

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The topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early or congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.

Calcium Channel Pharmacology
Calcium Channel Pharmacology

Author: Stefan I. McDonough

Publisher: Springer Science & Business Media

Published: 2011-06-28

Total Pages: 427

ISBN-13: 1441992545

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Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.

Gene Transfer
Gene Transfer

Author: Theodore Friedmann

Publisher: CSHL Press

Published: 2007

Total Pages: 769

ISBN-13: 0879697652

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Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

Reprogramming the Brain
Reprogramming the Brain

Author: Aage R. Moller

Publisher: Elsevier

Published: 2006-10-27

Total Pages: 423

ISBN-13: 0080465919

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The brain is plastic and it can change its function to adapt to changing demands of various kinds. The brain can also re-organize and change its function to better utilize its resources when parts of the brain have been damaged through injuries and diseases. This means that the brain is not "hard wired but can be reprogrammed when needed. This book describes different aspects of how the plasticity can become activated and how it can benefit the individual person. This book provides in-depth coverage of many important aspects of neural plasticity and how it applies to trauma, including strokes and disorders of the central nervous system that affect memory and cognition. The book also discusses how neural plasticity is involved in aphasia, pain and tinnitus. The roles of neural plasticity in motor rehabilitation and in adaptation to prostheses such as cochlear and cochlear nucleus implants are also topics of the book.* Provides in-depth coverage of many important aspects of neural plasticity and how it applies to trauma, including strokes and disorders of the central nervous system that affect memory and cognition* Discusses how neural plasticity is involved in aphasia, pain and tinnitus* Explains the roles of neural plasticity in motor rehabilitation and prosthesis such as cochlear and cochlear nucleus implants

Gene-Environment Interactions
Gene-Environment Interactions

Author: Lucio G. Costa

Publisher: John Wiley & Sons

Published: 2005-12-16

Total Pages: 577

ISBN-13: 0471758035

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Understanding the play between heredity and environment, and relating it to disease causation, is the task of ecogenetics. Gene-Environment Interactions: Fundamentals of Ecogenetics presents the first comprehensive survey of this discipline, reflecting its relationship with toxicology, epidemiology, pharmacology, public health, and other medical and biological fields. Divided into four sections, the text elucidates key basic and advanced topics: * Section 1 covers fundamentals, including the history of the discipline, a discussion of the molecular laboratory tools currently available to assess genotypes, using such measurements in molecular epidemiology studies, and the statistical issues involved in their analysis. * Section 2 focuses on a number of key genetic polymorphisms relevant for ecogenetics, including enzymes of phase I and phase II metabolism, enzymes involved in DNA repair, as well as receptors and ion channels. This highlights characteristics of selected, widely studied genotypic/phenotypic differences, and allows discussion of how given genetic variations can influence responses to exogenous chemicals. * Section 3 examines gene-environment interactions through a disease-based approach, addressing how genetic polymorphisms can influence susceptibility to various diseases. Chapters cover important disease conditions such as various types of cancer, neurodegenerative diseases, cardiovascular disease, chronic pulmonary diseases, infectious diseases, diabetes, and obesity. * The final section discusses the ethical, legal, and social issues that arise when investigating and evaluating genetic polymorphisms in human populations, as well as the impact of ecogenetics on risk assessment, regulatory policies, and medicine and public health. Packed with clear examples illustrating concepts, as well as numerous tables and figures, Gene-Environment Interactions: Fundamentals of Ecogenetics is a unique resource for a wide range of physicians, students, and other specialists.