Enhanced Bone Healing with BCP Granules Implanted with BMP-2 and MSCs in a Rabbit Calvarial Defect
Enhanced Bone Healing with BCP Granules Implanted with BMP-2 and MSCs in a Rabbit Calvarial Defect

Author: Sun-Sik Yang

Publisher:

Published: 2017

Total Pages:

ISBN-13:

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The aim of this study was to evaluate the in vivo osteogenic potential of biphasic calcium phosphate (BCP), bone morphogenetic protein 2 (BMP-2), and/or mesenchymal stem cell (MSC) composites by using a rabbit calvarial defect model. Bone formation was assessed by using three different kinds of implants in rabbit calvarial defects, BCP alone, BCP/recombinant human (rh) BMP-2, and BCP/rhBMP-2/MSCs composite. The implants were harvested after 2 or 8 weeks, and the area of new bone formation was quantified by micro-computed tomography (micro-CT) and histologic studies. The highest bone formation was achieved with the BCP/rhBMP-2/MSCs treatment, and it was significantly higher than that achieved with the empty or BCP-alone treatment. The quantity of new bone at 8 weeks was greater than at 2 weeks in each group. The relative density of osteocalcin immunoreactivity also increased during this interval. These results indicate that the combination of BCP, rhBMP-2, and MSCs synergistically enhances osteogenic potential during the early healing period and could be used as a bone graft substitute.

An Introduction to Tissue-Biomaterial Interactions
An Introduction to Tissue-Biomaterial Interactions

Author: Kay C. Dee

Publisher: John Wiley & Sons

Published: 2003-04-14

Total Pages: 250

ISBN-13: 0471461121

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An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body’s wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today’s and tomorrow’s implantable biomedical devices.

Definitions of Biomaterials for the Twenty-First Century
Definitions of Biomaterials for the Twenty-First Century

Author: Xingdong Zhang

Publisher: Elsevier

Published: 2019-06-20

Total Pages: 292

ISBN-13: 012818292X

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Definitions of Biomaterials for the Twenty-First Century is a review of key, critical biomaterial terms and definitions endorsed by the International Union of Societies for Biomaterials Science and Engineering. The topics and definitions discussed include those in general biomaterials and applications, biocompatibility, implantable and interventional devices, drug delivery systems, regenerative medicine and emerging biomaterials. The book reviews the discussion of these terms by leaders in the global biomaterials community and summarizes the agreed upon definitions. - Provides readers with the official definitions of critical biomaterials terms endorsed by the International Union of Societies for Biomaterials Science and Engineering - Includes the combined contributions from more than 50 global leaders in the biomaterials community - Updates terms based on the latest advances in clinical and scientific understanding and expanded scope of biomaterials science

In Situ Tissue Regeneration
In Situ Tissue Regeneration

Author: Sang Jin Lee

Publisher: Academic Press

Published: 2016-07-17

Total Pages: 460

ISBN-13: 012802500X

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In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. - Explores the body's ability to mobilize endogenous stem cells to the site of injury - Details the latest strategies developed for inducing and supporting the body's own regenerating capacity - Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume - Features chapter authors and editors who are authorities in this emerging field - Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

Current Concepts in Dental Implantology
Current Concepts in Dental Implantology

Author: Ilser Turkyilmaz

Publisher: BoD – Books on Demand

Published: 2015-02-25

Total Pages: 278

ISBN-13: 9535117416

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Implant dentistry has changed and enhanced significantly since the introduction of osseointegration concept with dental implants. Because the benefits of therapy became apparent, implant treatment earned a widespread acceptance. Therefore, the need for dental implants has caused a rapid expansion of the market worldwide. Dental implantology continues to excel with the developments of new surgical and prosthodontic techniques, and armamentarium. The purpose of this book named Current Concepts in Dental Implantology is to present a novel resource for dentists who want to replace missing teeth with dental implants. It is a carefully organized book, which blends basic science, clinical experience, and current and future concepts. This book includes ten chapters and our aim is to provide a valuable source for dental students, post-graduate residents and clinicians who want to know more about dental implants.

Bone Pathology
Bone Pathology

Author: Jasvir S. Khurana

Publisher: Springer Science & Business Media

Published: 2009-12-02

Total Pages: 419

ISBN-13: 1597453471

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Bone Pathology is the second edition of the book, A Compendium of Skeletal Pathology that published 10 years ago. Similar to the prior edition, this book complements standard pathology texts and blends new but relatively established information on the molecular biology of the bone. Serving as a bench-side companion to the surgical pathologist, this new edition reflects new advances in our understanding of the molecular biology of bone. New chapters on soft-tissue sarcomas and soft-tissue tumors have been added as well as several additional chapters such as Soft-tissue pathology and Biomechanics. The volume is written by experts who are established in the field of musculoskeletal diseases. Bone Pathology is a combined effort from authors of different specialties including surgeons, pathologists, radiologists and basic scientists all of whom have in common an interest in bone diseases. It will be of great value to surgical pathology residents as well as practicing pathologists, skeletal radiologists, orthopedic surgeons and medical students.

Octacalcium Phosphate
Octacalcium Phosphate

Author: L. C. Chow

Publisher:

Published: 2001

Total Pages: 0

ISBN-13: 9783318007046

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The chemistry, structure and biological importance of octacalcium phosphate (OCP) are thoroughly discussed in this volume, which covers a wide scope of topics relevant to the field of calcium phosphates in general. The first chapter reviews the structures of OCP and other important calcium phosphates. It is followed by a description of the mimicry of OCP growth in vivo using in vitro model systems and an extensive review of OCP in biological systems. The remarkable ability of OCP to incorporate biologically relevant organic carboxylates into its structure is also discussed, along with the solubility and surface properties of calcium phosphate salts, and amorphous calcium phosphate and its relationship to OCP. The last chapter centers on the emerging technology of calcium phosphate cements as bone defect repair materials. The book provides in-depth, up-to-date information to all scientists studying calcium phosphate chemistry, biomineralization, pathological calcification, dental caries, biomaterials, and recovery of environmental phosphorus.

Developments and Applications of Calcium Phosphate Bone Cements
Developments and Applications of Calcium Phosphate Bone Cements

Author: Changsheng Liu

Publisher: Springer

Published: 2017-10-20

Total Pages: 632

ISBN-13: 9811059756

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This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.