Nanobiomaterials in Soft Tissue Engineering
Nanobiomaterials in Soft Tissue Engineering

Author: Alexandru Grumezescu

Publisher: William Andrew

Published: 2016-02-23

Total Pages: 530

ISBN-13: 0323428886

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Nanobiomaterials in Soft Tissue Engineering brings together recent developments and the latest approaches in the field of soft tissue engineering at the nanoscale, offering a new perspective on the evolution of current and future applications. Leading researchers from around the world present the latest research and share new insights. This book covers the major conventional and unconventional fabrication methods of typical three-dimensional scaffolds used in regenerative medicine. Surface modification and spatial properties are included in an up-to-date overview, with the latest in vivo applications of engineered 3D scaffolds discussed. The book also considers the impact, advantages and future scope of the various methods. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. - An informative handbook for researchers, practitioners and students working in biomedical, biotechnological and engineering fields. - A detailed and invaluable overview of soft tissue engineering, including the most recent scientific developments. - Proposes novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology.

Open-Space Microfluidics
Open-Space Microfluidics

Author: Emmanuel Delamarche

Publisher: John Wiley & Sons

Published: 2018-01-18

Total Pages: 450

ISBN-13: 3527696792

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Summarizing the latest trends and the current state of this research field, this up-to-date book discusses in detail techniques to perform localized alterations on surfaces with great flexibility, including microfluidic probes, multifunctional nanopipettes and various surface patterning techniques, such as dip pen nanolithography. These techniques are also put in perspective in terms of applications and how they can be transformative of numerous (bio)chemical processes involving surfaces. The editors are from IBM Zurich, the pioneers and pacesetters in the field at the forefront of research in this new and rapidly expanding area.

Tissue Engineering
Tissue Engineering

Author: Chandra P. Sharma

Publisher: Academic Press

Published: 2022-01-25

Total Pages: 724

ISBN-13: 0128240652

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Tissue Engineering: Current Status and Challenges bridges the gap between biomedical scientists and clinical practitioners. The work reviews the history of tissue engineering, covers the basics required for the beginner, and inspires those in the field toward future research and application emerging in this fast-moving field. Written by global experts in the field for those studying and researching tissue engineering, the book reviews regenerative technologies, stem cell research and regeneration of organs. It then moves to soft tissue engineering (heart, vascular, muscle and 3D scaffolding and printing), hard tissue engineering (bone, dental myocardial and musculoskeletal) and translational avenues in the field. - Introduces readers to the history and benefits of tissue engineering - Includes coverage of new techniques and technologies, such as nanotechnology and nanoengineering - Presents concepts, ideology and theories which form the foundation for next-generation tissue engineering

Liquid Film Coating
Liquid Film Coating

Author: P.M. Schweizer

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 794

ISBN-13: 9401153426

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This multi-authored volume provides a comprehensive and in-depth account of the highly interdisciplinary science and technology of liquid film coating. The book covers fundamental principles from a wide range of scientific disciplines, including fluid mechanics aand transport phenomena, capillary hydrodynamics, surface and colloid science. The authors, all acknowledged eperts in their fields, represent a balance between industrial and academic points of view. Throughout the text, many case studies illustrate how scientific principles together with advanced experimental and theoretical methods are applied to develop and optimize manufacturing processes of eve increasing sophiatication and efficiency. In the first part of the book, the authors systematically recount the underlying physical principles and important material properties. The second part of the book gives a comprehensive overview of the most advanced experimental, mathematical and computational methods available today to investigate coating processes. The third part provides an overview and critical literature review for all major classes of liquid film coating processes of industrial importance.

Alternatives to Animal Testing
Alternatives to Animal Testing

Author: Hajime Kojima

Publisher: Springer

Published: 2018-12-27

Total Pages: 136

ISBN-13: 9811324476

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This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.

Stem Cell and Tissue Engineering
Stem Cell and Tissue Engineering

Author: Song Li

Publisher: World Scientific

Published: 2011

Total Pages: 473

ISBN-13: 9814317055

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Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. It serves as a valuable reference book for researchers and students.

Mammalian Toxicology
Mammalian Toxicology

Author: Mohamed Abou-Donia

Publisher: John Wiley & Sons

Published: 2015-05-04

Total Pages: 716

ISBN-13: 1119940419

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Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.

Essentials of 3D Biofabrication and Translation
Essentials of 3D Biofabrication and Translation

Author: Anthony Atala

Publisher: Academic Press

Published: 2015-07-17

Total Pages: 441

ISBN-13: 0128010150

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Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. - Provides a new and versatile method to fabricating living tissue - Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction - Describes current approaches and future challenges for translational science - Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms

Recombinant Glycoprotein Production
Recombinant Glycoprotein Production

Author: Virgínia Picanço-Castro

Publisher: Humana

Published: 2018-08-18

Total Pages: 0

ISBN-13: 9781493984497

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This volume covers a wide spectrum of techniques and approaches that are used in the upstream and downstream processing for recombinant glycoprotein production. Chapters guide the reader through state-of-art of therapeutic recombinant glycoproteins, explores the patent literature, expression systems used for glycoproteins production, methods employed in the downstream processing of different glycoproteins, and information about analytical tools and formulation strategies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Recombinant Glycoprotein Production: Methods and Protocols aims to ensure successful results in the further study of this vital field

Cardiac Extracellular Matrix
Cardiac Extracellular Matrix

Author: Eric G. Schmuck

Publisher: Springer

Published: 2018-09-20

Total Pages: 252

ISBN-13: 3319974211

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This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.