Eminent Maricones

Eminent Maricones

Author: Jaime Manrique

Publisher: Univ of Wisconsin Press

Published: 1999

Total Pages: 132

ISBN-13: 9780299161842

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One of the leading Latino writers working today offers a provocative autobiography interweaving his own story with the lives of three other gay Hispanic authors: Manuel Puig, Reinaldo Arenas, and Federico Garcia Lorca.


Francis Crick

Francis Crick

Author: Matt Ridley

Publisher: Harper Collins

Published: 2012-01-17

Total Pages: 228

ISBN-13: 0062200666

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Francis Crick—the quiet genius who led a revolution in biology by discovering, quite literally, the secret of life—will be bracketed with Galileo, Darwin, and Einstein as one of the greatest scientists of all time. In his fascinating biography of the scientific pioneer who uncovered the genetic code—the digital cipher at the heart of heredity that distinguishes living from non-living things—acclaimed bestselling science writer Matt Ridley traces Crick's life from middle-class mediocrity in the English Midlands through a lackluster education and six years designing magnetic mines for the Royal Navy to his leap into biology at the age of thirty-one and its astonishing consequences. In the process, Ridley sheds a brilliant light on the man who forever changed our world and how we understand it.


Drug Discovery

Drug Discovery

Author: Jie Jack Li

Publisher: John Wiley & Sons

Published: 2013-04-03

Total Pages: 572

ISBN-13: 111835446X

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Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.


The Discovery of Jeanne Baret

The Discovery of Jeanne Baret

Author: Glynis Ridley

Publisher: Crown

Published: 2011-12-06

Total Pages: 314

ISBN-13: 0307463532

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The year was 1765. Eminent botanist Philibert Commerson had just been appointed to a grand new expedition: the first French circumnavigation of the world. As the ships’ official naturalist, Commerson would seek out resources—medicines, spices, timber, food—that could give the French an edge in the ever-accelerating race for empire. Jeanne Baret, Commerson’s young mistress and collaborator, was desperate not to be left behind. She disguised herself as a teenage boy and signed on as his assistant. The journey made the twenty-six-year-old, known to her shipmates as “Jean” rather than “Jeanne,” the first woman to ever sail around the globe. Yet so little is known about this extraordinary woman, whose accomplishments were considered to be subversive, even impossible for someone of her sex and class. When the ships made landfall and the secret lovers disembarked to explore, Baret carried heavy wooden field presses and bulky optical instruments over beaches and hills, impressing observers on the ships’ decks with her obvious strength and stamina. Less obvious were the strips of linen wound tight around her upper body and the months she had spent perfecting her masculine disguise in the streets and marketplaces of Paris. Expedition commander Louis-Antoine de Bougainville recorded in his journal that curious Tahitian natives exposed Baret as a woman, eighteen months into the voyage. But the true story, it turns out, is more complicated. In The Discovery of Jeanne Baret, Glynis Ridley unravels the conflicting accounts recorded by Baret’s crewmates to piece together the real story: how Baret’s identity was in fact widely suspected within just a couple of weeks of embarking, and the painful consequences of those suspicions; the newly discovered notebook, written in Baret’s own hand, that proves her scientific acumen; and the thousands of specimens she collected, most famously the showy vine bougainvillea. Ridley also richly explores Baret’s awkward, sometimes dangerous interactions with the men on the ship, including Baret’s lover, the obsessive and sometimes prickly naturalist; a fashion-plate prince who, with his elaborate wigs and velvet garments, was often mistaken for a woman himself; the sour ship’s surgeon, who despised Baret and Commerson; even a Tahitian islander who joined the expedition and asked Baret to show him how to behave like a Frenchman. But the central character of this true story is Jeanne Baret herself, a working-class woman whose scientific contributions were quietly dismissed and written out of history—until now. Anchored in impeccable original research and bursting with unforgettable characters and exotic settings, The Discovery of Jeanne Baret offers this forgotten heroine a chance to bloom at long last.