Emerging Anti-cancer Compounds and Immunomodulators for Pancreatic Cancer Treatment
Emerging Anti-cancer Compounds and Immunomodulators for Pancreatic Cancer Treatment

Author: Stephen Safe

Publisher: Frontiers Media SA

Published: 2024-04-29

Total Pages: 103

ISBN-13: 2832548482

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Pancreatic cancer is a highly lethal gastrointestinal disease that is becoming one of the leading causes of cancer mortality worldwide. Despite advances in surgery, radiation therapy, immuno-oncology, and therapeutics, the 5-year survival rate for pancreatic cancer patients remains around 12%. The poor prognosis is mainly due to late diagnosis, as pancreatic cancer patients commonly don’t exhibit symptoms until an advanced stage that is beyond surgical resection. Currently, the main treatments for patients with advanced pancreatic cancer are chemotherapy, radiotherapy, and most recent clinical trials incorporate immunotherapy.

New Mechanisms for Anti-Cancer Drugs
New Mechanisms for Anti-Cancer Drugs

Author: Ayaz Shahid

Publisher: Frontiers Media SA

Published: 2024-04-15

Total Pages: 353

ISBN-13: 2832547842

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Cancer is the second leading cause of death. Every year, many anticancer drug candidates are discovered and synthesized, but the major challenge lies in identifying, characterizing and evaluating their efficacy. The aim of this Research Topic, "New Mechanisms for Anti-Cancer Drugs" is to collect a group of publications focused on novel chemical compounds exhibiting new modes of actions and/or new target proteins to fulfill their cytotoxic activity on cancer cells. In this context, we will also be pleased to consider studies on drug repurposing, including approved, discontinued, and shelved drugs, when anti-cancer activity results from an unexpected mode of action.

Skills for Midwifery Practice Australian & New Zealand Edition
Skills for Midwifery Practice Australian & New Zealand Edition

Author: Sally-Ann De-Vitry Smith

Publisher: Elsevier Health Sciences

Published: 2022-02-28

Total Pages: 582

ISBN-13: 0729589447

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This text provides clear, easy-to-read guidance on more than 110 skills for midwifery students and midwives seeking to update their practice. Underpinned with the most recent evidence-based practice and research, the second edition walks the reader through general and basic skills in a sequential and logical manner, following a woman’s journey through pregnancy, labour and birth, and postnatal care. With a focus on the performance of midwifery skills rather than on the theory of midwifery practice, Skills for Midwifery Practice Australia and New Zealand 2nd edition is an indispensable text to which students will return to again and again. Endorsed by the Australian College of Midwives Step-by-step instructions for each skill Images and diagrams to aid understanding A woman-centred approach and cultural considerations throughout Models of midwifery care (Continuity of Care and Lead Maternity Carer’s Model) Australian/NZ specific guidelines, policies, statistics, terminology and medication administration guidelines

Exploring the Impact of Genetics on New Drugs and Potential Drug Targets: A Multi-Omics Approach to Improve Personalized Therapeutics.
Exploring the Impact of Genetics on New Drugs and Potential Drug Targets: A Multi-Omics Approach to Improve Personalized Therapeutics.

Author: Shaoqiu Chen

Publisher: Frontiers Media SA

Published: 2024-07-08

Total Pages: 132

ISBN-13: 2832551475

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In recent years, significant advancements have been made in the field of new drug development. With the advent of high-throughput sequencing technologies, the identification of new drug targets has become more efficient and precise. In addition, multi-omics approaches, including genomics, transcriptomics, proteomics, and metabolomics, have emerged as a powerful tool for understanding the complexity of diseases and identifying new therapeutic targets.

Key Heterocyclic Cores for Smart Anticancer Drug–Design Part II
Key Heterocyclic Cores for Smart Anticancer Drug–Design Part II

Author: Rajesh Kumar Singh

Publisher: Bentham Science Publishers

Published: 2022-09-02

Total Pages: 231

ISBN-13: 9815040057

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This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 2 of the book set covers these topics: - Anticancer targets for heterocyclic lead compounds - Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity - Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds - Natural products as anticancer agents