Emerging Challenges of Cardiovascular and Metabolic Dysfunctions in Cardio-oncology: From Bench to Bedside
Emerging Challenges of Cardiovascular and Metabolic Dysfunctions in Cardio-oncology: From Bench to Bedside

Author: Canan G. Nebigil

Publisher: Frontiers Media SA

Published: 2020-10-27

Total Pages: 127

ISBN-13: 2889660958

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Endocrine and Metabolic Late Effects in Cancer Survivors
Endocrine and Metabolic Late Effects in Cancer Survivors

Author: Francesco Felicetti (Oncologist)

Publisher: Karger Medical and Scientific Publishers

Published: 2021-11

Total Pages: 169

ISBN-13: 3318067911

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This book analyzes in detail all aspects related to endocrine and metabolic late effects observed in patients treated for cancer, both in childhood and adulthood. The chapters focusing on the possible pathogenic mechanisms of late effects (i.e., premature aging and chronic inflammation) and on bone health in cancer survivors are particularly interesting and innovative. The volume also deals with hypothalamic-pituitary, thyroid and gonadal disorders, including infertility and how to prevent it. Finally, the relationship between metabolic alterations and cardiovascular diseases in cancer survivors is addressed. Thanks to advances in cancer treatment and supportive care, the five-year survival rate of cancer patients is constantly increasing. However, this undisputable success of medicine has a flip side: the late adverse effects of anticancer therapies. Pediatric oncologists were the first to cope with late complications of treatments, but today also adult oncologists and onco-hematologists recognize the relevance of this issue. Even though late effects observed in cancer survivors can affect any organ or system, endocrine and metabolic dysfunctions are the most frequently reported. Endocrine complications rarely influence life expectancy of cancer survivors, but they can significantly impact morbidity and quality of life. Among endocrine adverse effects, severe hypothalamic damage may be considered the most harmful in survivors, leading to morbid obesity, propensity to metabolic syndrome and cardiovascular disease. This book aims to disseminate the knowledge about endocrine and metabolic adverse effects of cancer therapies and about survivorship care. Since the number of cancer survivors is steadily growing in the general population, this publication is intended not only for endocrinologists but also for oncologists, onco-hematologists, internists, pediatric specialists in those areas and general practitioners, with the aim to better counsel and monitor cancer survivors.

Mechanisms of Angiogenesis
Mechanisms of Angiogenesis

Author: Matthias Clauss

Publisher: Springer Science & Business Media

Published: 2004-11-22

Total Pages: 342

ISBN-13: 9783764364595

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Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.

Stroke Genetics
Stroke Genetics

Author: Hugh S. Markus

Publisher:

Published: 2003

Total Pages: 362

ISBN-13: 0198515863

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Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. An increasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke. Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemic stroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence is reviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing a practical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.

Cardio-Oncology: From Bench to Bedside
Cardio-Oncology: From Bench to Bedside

Author: Jun-ichi Abe

Publisher: Frontiers Media SA

Published: 2019-05-17

Total Pages: 113

ISBN-13: 288945875X

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Cardio-oncology is a medical subspecialty concerned with the diagnosis and treatment of cardiovascular disease (CVD) and organ failure mediated by micro- to macro-circulation defects in cancer patients and survivors. The risk of CVD in cancer survivors is eight times higher than the general population, and the relative risk of coronary artery disease and heart failure (HF) is 10 times and 15 times higher, respectively, compared to their siblings without cancer. It is important to note that cancer treatments including chemotherapy and radiation can lead to both short- (< 1 year) and long-term (> 5 years) cardiovascular complications. Previously, Dr. Edward T.H. Yeh initiated the MD Anderson Practice (MAP) project, and published 16 MAPs to provide the current best practice we considered at UT MD Anderson. As shown in these MAPs, one of the key issues of cardio-oncology practice and science is how we can allow cancer patients to receive maximum and uninterrupted treatments for cancer while protecting them from cancer therapy-mediated cardiovascular complications. Therefore, it is crucial to understand not only pathophysiology of CVD, but also mechanistic insights of how each cancer treatment can control cancer growth and metastasis. Without having the profound knowledge in the pathophysiological, clinical and epidemiologic aspects of cardiovascular complications of existing cancer therapy, it is impossible to establish the strong evidence-based strategies and approaches for both short- and long-term cardiovascular complications after cancer treatment. In addition, we believe that cardio-oncology science should not be restricted to deal with the side effects of each specific cancer drug, because many common cardiovascular phenotypes among the different cancer treatments are also observed. This Research Topic provides a comprehensive overview from both of the current research and practice, and a platform for obtaining the logical and up-to-date treatment and prevention of CVD in cancer patients and survivors.

Advances & Innovations in Heart Failure (AIHF)
Advances & Innovations in Heart Failure (AIHF)

Author: HK Chopra

Publisher: Jaypee Brothers Medical Publishers

Published: 2020-02-28

Total Pages: 995

ISBN-13: 9389587891

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Heart failure is a serious condition caused by the heart failing to pump enough blood around the body at the right pressure. It usually occurs because the heart muscle has become too weak or stiff to work properly, most commonly caused by heart attack, high blood pressure or cardiomyopathy (heart disease). This textbook is a comprehensive guide to the latest advances in the diagnosis and management of heart failure. Comprising nearly 1000 pages, the book features 15 sections, beginning with discussion on clinical issues of heart failure, followed by imaging techniques. Each of the following sections covers a different disorder or disease that subsequently may lead to heart failure. Topics include coronary artery disease, stroke, arrhythmia, hypertension, nutritional aspects, cardio-oncology, and much more. The book concludes with rehabilitation, legal aspects, and future directions. Authored by internationally recognised experts in the field, the text is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to latest advances in diagnosis and management of heart failure Extensive text comprising nearly 1000 pages covering numerous associated disorders and diseases Internationally recognised editor and author team Highly illustrated with clinical photographs, diagrams and tables

Targeted Therapies in Breast Cancer
Targeted Therapies in Breast Cancer

Author: Gw Sledge

Publisher: Clinical Pub

Published: 2012-06

Total Pages: 0

ISBN-13: 9781846920660

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This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

ASE's Comprehensive Strain Imaging, E-Book
ASE's Comprehensive Strain Imaging, E-Book

Author: Thomas H. Marwick

Publisher: Elsevier Health Sciences

Published: 2021-05-01

Total Pages: 264

ISBN-13: 0323759483

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Strain imaging (also known as speckle-tracking echocardiography or STE) is a rapidly growing, affordable, and versatile cardiac imaging technology of great interest to clinicians in both inpatient and outpatient settings. ASE's Comprehensive Strain Imaging is the first reference designed to help you master a wide range of strain imaging/STE applications, including screening, diagnosis, treatment, and follow up. Written and edited by a team of international experts from the American Society of Echocardiography (ASE), this new resource provides the information you need to optimize imaging acquisition and analysis using this important new echocardiography method. - Covers step-by-step techniques on how to use strain imaging with expert tips on nuances, pitfalls, and clinical decision making. - Discusses the growing range of strain imaging applications for assessing diastolic function, atrial function, heart failure, arterial disease, valve disease, hypertrophy, and other common cardiovascular conditions. - Provides up-to-date information on screening and follow up of patients who receive cardio-toxic oncologic agents during cancer treatment and evaluation of patients with cardiomyopathy, heart failure, arterial disease, valve disease, implantable pacemakers, pericardial disease, hypertrophy, ischemic disease, and chest radiation. - Includes more than 150 images using the latest strain imaging technology, as well as videos that depict evaluation and monitoring of patients with cardiomyopathies. - Addresses future applications, including elastography.

Stem Cells
Stem Cells

Author: Ariff Bongso

Publisher: World Scientific

Published: 2011

Total Pages: 721

ISBN-13: 9814289388

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Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today. It also covers the conversion of stem cell types into a variety of useful tissues which may be used in the future for transplantation therapy. It is thus aimed at undergraduates, postgraduates, scientists, embryologists, doctors, tissue engineers and anyone who wishes to gain some insight into stem cell biology. This book is important as it is comprehensive and covers all aspects of stem cell biology, from basic research to clinical applications. It will have 33 chapters written by renowned stem cell scientists worldwide. It will be up-to-date and all the chapters include self-explanatory figures, color photographs, graphics and tables. It will be easy to read and give the reader a complete understanding and state of the art of the exciting science and its applications.

Handbook of Sepsis
Handbook of Sepsis

Author: W. Joost Wiersinga

Publisher: Springer

Published: 2018-04-13

Total Pages: 264

ISBN-13: 3319735063

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This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.