Electrophysiological Studies of a Retinal Prosthetic Prototype
Electrophysiological Studies of a Retinal Prosthetic Prototype

Author: Fei Huang

Publisher:

Published: 2012

Total Pages: 220

ISBN-13:

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Abstract: Retinal prostheses are becoming a viable therapy for inner retinal degeneration caused by age related macular degeneration (AMD) and retinitis pigmentosa (RP). The majority of ocular and periocular prosthetic devices employ photodiodes and a microelectrode interface to convert light into a nerve impulse within the retina. Problems with this design include the need of an external power source, the lack of biocompatibility of the microelectrode array, and the need for complicated surgical procedures. Self-assembled monolayer (SAM) technology offers an alternative strategy, where neurons can be stimulated by light activation of a single layer of a photovoltaic SAM. We have developed a SAM structure where the photoexcitable dye 2-[2-[4-(dibutylamino)phenyl]ethenyl]-3-caboxymethylbenzothiazolium bromide (NK5962) was covalently immobilized to an indium tin oxide (ITO) and 3-(aminopropyl) trimethoxysilane (APTMS) surface. The NK562 derivatized surface was characterized through contact angle goniometry, electrochemical impedance spectroscopy, grazing angle infrared spectroscopy, and ultraviolet-visible absorption spectrophotometry. NG108-15 neurons were differentiated onto the surface and neural responses from electrical stimulation and photostimulation of the system were measured using whole-cell current and voltage clamp methodologies. We found an average 2.9 mV decrease in NG108-15 threshold potential for every 10 mV increase in ITO surface potential. Following photostimulation, there was a 1.8±0.2 fold increase (p

Ryan's Retina E-Book
Ryan's Retina E-Book

Author: Charles P. Wilkinson

Publisher: Elsevier Health Sciences

Published: 2017-04-17

Total Pages: 2893

ISBN-13: 0323401988

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The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training. Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas. Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis. Includes more than 1,150 brand-new illustrations, scans, and photographs throughout. Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A). Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Features an expanded online video library highlighting the latest surgical techniques and new coverage of complications of vitreoretinal surgery. Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

Artificial Vision
Artificial Vision

Author: Veit Peter Gabel

Publisher: Springer

Published: 2016-11-24

Total Pages: 233

ISBN-13: 3319418769

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This book presents and analyses the most recent research dedicated to restoring vision in individuals who are severely impaired or blind from retinal disease or injury. It is written by the leading groups worldwide who are at the forefront of developing artificial vision. The book begins by discussing the difficulties in comparing and interpreting functional results in the area of very low vision and the principal prospects and limitations of spatial resolution with artificial tools. Further on, chapters are included by researchers who stimulate the surface or the pigment epithelial side of the retina and by experts who work on stimulating the optic nerve, the lateral geniculate body and the superficial layers of the visual cortex. Artificial Vision: A Clinical Guide collates the most recent work of key artificial vision research groups to explain in a comparable and stringent order their varying approaches, the clinical or preclinical outcomes and their achievements during the last years. Senior ophthalmic fellows and academic practitioners will find this guide to be an indispensable resource for understanding the current status of artificial vision.

Artificial Sight
Artificial Sight

Author: Mark S. Humayun

Publisher: Springer Science & Business Media

Published: 2007-09-30

Total Pages: 407

ISBN-13: 038749331X

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This book describes advances in implantable neural stimulation technology to restore partial sight to people who are blind from retinal degnerative diseases such as age-related macular degeneration and retintis pigmentosa. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The book summarizes the state of research and clinical practice in the field and reviews the current ideas and approaches of its leading researchers and practitioners.

Neural Computation, Neural Devices, and Neural Prosthesis
Neural Computation, Neural Devices, and Neural Prosthesis

Author: Zhi Yang

Publisher: Springer Science & Business Media

Published: 2014-04-15

Total Pages: 395

ISBN-13: 1461481511

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In the past decades, interdisciplinary investigations overlapping biology, medicine, information science, and engineering have formed a very exciting and active field that attracts scientists, medical doctors, and engineers with knowledge in different domains. A few examples of such investigations include neural prosthetic implants that aim to improve the quality of life for patients suffering from neurologic disease and injury; brain machine interfaces that sense, analyze, and translate electrical signals from the brain to build closed-loop, biofeedback systems; and fundamental studies of intelligence, cognitive functions, and psychological behaviors correlated to their neurological basis. Although this interdisciplinary area is still in its infancy, it can potentially create some of the most significant impact: treating diseases that are considered untreatable, interpretation and communication of neuron ensembles, or even a revolutionary perception and understanding of life different from philosophical or immaterial approaches. Fortunately, several academic societies recognize the value and impact of this growing field, firmly supporting related research. Such support will drive a booming future in the next twenty or thirty years. Research in this area is frequently project-driven, and the generated knowledge has been scattered in different fields of neuroscience, computation, material and technology, circuits and system, clinical reports, and psychology—the scope considerably across the boundary of traditionally defined disciplines. Neural Computation, Neural Devices, and Neural Prosthesis is intended to assemble such knowledge, from there suggesting a systematic approach guiding future educational and research activities. The targeted audience includes both students and researchers.

Retina E-Book
Retina E-Book

Author: Charles P. Wilkinson

Publisher: Elsevier Health Sciences

Published: 2012-11-01

Total Pages: 2498

ISBN-13: 1455737801

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Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.

Suprachoroidal Space Interventions
Suprachoroidal Space Interventions

Author: Shohista Saidkasimova

Publisher: Springer Nature

Published: 2021-09-28

Total Pages: 166

ISBN-13: 3030768538

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This book provides a practical overview of pathology and interventions in the suprachoroidal space of the eye. Concise and well-structured chapters examine anatomy, physiology and pathophysiology, suprachoroidal haemorrhage, choroidal effusions and ocular hypotony management, imaging, suprachoroidal buckling for retinal detachment, drug delivery, suprachoroidal glaucoma devices, subretinal gene therapy and suprachoroidal retinal implant. Suprachoroidal Space Interventions meets the need for a book that improves awareness of established and novel interventions in the suprachoroidal space, particularly as it has been increasingly recognised as a potential space for glaucoma surgery, drug deliveries and retinal surgery. Ophthalmologists and scientists with an interest in glaucoma and retinal surgery will find the book to be an easy to use reference tool for a rapidly developing area of ophthalmology that can be applied in modern clinical practice.

Handbook of Neuroengineering
Handbook of Neuroengineering

Author: Nitish V. Thakor

Publisher: Springer Nature

Published: 2023-02-02

Total Pages: 3686

ISBN-13: 9811655405

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This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​