Electrophysiological Investigation of Age-related Macular Degeneration
Author: Alison Mary Binns
Publisher:
Published: 2005
Total Pages: 728
ISBN-13:
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Electrophysiological and Genetic Aspects of Age-related Macular Degeneration (AMD)
Author: Ioannis Dimopoulos
Publisher:
Published: 2014
Total Pages: 178
ISBN-13:
DOWNLOAD EBOOKAge-related macular degeneration (AMD) is considered a heterogeneous group of disorders. Although many genes influence susceptibility to disease, none has shown to be the primary contributor. To identify genetic contributors, distinct AMD phenotypes need to be established. We relied on electrophysiological testing (ERG) to detect homogeneous subgroups for future genotype-phenotype association studies. We also classified AMD patients based on refractoriness to anti-VEGF treatment to investigate genetic associations with known high-risk single nucleotide polymorphisms (SNPs). Our results suggest that generalized cone dysfunction and delayed rod phototransduction activation characterizes a subset of AMD patients, while impaired dark adaptation constitutes a universal feature of the disease. We were unable to unify all patients unresponsive to anti- VEGF monotherapy under a single SNP haplotype, highlighting the genetic complexity underlying the disorder and its treatment prediction. By applying a novel approach to investigate potential pharmacogenetic interactions, we provided evidence that variation in multiple susceptibility loci may better explain differential response to anti-VEGF therapy. Treatment with prolonged VEGF blockade was found to result in inner retina dysfunction in a subset of AMD patients. Therefore, pharmacogenetic research holds promise in developing individualized approaches for AMD treatment in the future, which will not only optimize final patient outcome, but also reduce the risk of adverse effects.
Age-Related Macular Degeneration, Third Edition
Author: Jennifer I. Lim
Publisher: CRC Press
Published: 2012-11-15
Total Pages: 399
ISBN-13: 1841849502
DOWNLOAD EBOOKThe value of Age-Related Macular Degeneration has stood the test of time, but progress in both basic and clinical ophthalmology has been relentless, mandating the need for an updated book. This second edition focuses on the pathophysiology and the epidemiology of age-related macular degeneration (AMD), the clinical features and management of dry an
Principles and Practice of Clinical Electrophysiology of Vision, second edition
Author: John R. Heckenlively
Publisher: MIT Press
Published: 2006-04-07
Total Pages: 1033
ISBN-13: 0262083469
DOWNLOAD EBOOKThe long-awaited second edition of an authoritative reference on electrophysiologic vision testing, including detailed information on techniques and problems, basic physiology and anatomy, theoretical concepts, and clinical findings; with extensive new material. This authoritative text is the only comprehensive reference available on electrophysiologic vision testing, offering both practical information on techniques and problems as well as basic physiology and anatomy, theoretical concepts, and clinical correlations. The second edition, of the widely used text, offers extensive new material and updated information: 65 of the 84 chapters are completely new, with the changes reflecting recent advances in the field. The book will continue to be an essential resource for practitioners and scholars from a range of disciplines within vision science. The contributions not only cover new information—important material that is likely to become more important in the next decade—but also offer a long-range perspective on the field and its remarkable development in the last century. After discussing the history and background of clinical electrophysiology, the book introduces the anatomy of the retina and principles of cell biology in the visual pathways at the molecular, physiological, and biochemical levels. It relates these new findings to the techniques and interpretations of clinical tests, including the electro-oculogram (EOG), electroretinogram (ERG), and visual evoked potentials (VEP), which are discussed in detail, as are equipment, data acquisition and analysis, principles and protocols for clinical testing, diseases and dysfunction, and animal testing. Notable additions for this edition include chapters on the origin of electroretinogram waveforms, multifocal techniques, testing in standard laboratory animals, recent advances in analysis of abnormalities in disease, and the applications of these techniques to the study of genetic abnormalities.
Electrophysiological Studies of a Retinal Prosthetic Prototype
Author: Fei Huang
Publisher:
Published: 2012
Total Pages: 220
ISBN-13:
DOWNLOAD EBOOKAbstract: Retinal prostheses are becoming a viable therapy for inner retinal degeneration caused by age related macular degeneration (AMD) and retinitis pigmentosa (RP). The majority of ocular and periocular prosthetic devices employ photodiodes and a microelectrode interface to convert light into a nerve impulse within the retina. Problems with this design include the need of an external power source, the lack of biocompatibility of the microelectrode array, and the need for complicated surgical procedures. Self-assembled monolayer (SAM) technology offers an alternative strategy, where neurons can be stimulated by light activation of a single layer of a photovoltaic SAM. We have developed a SAM structure where the photoexcitable dye 2-[2-[4-(dibutylamino)phenyl]ethenyl]-3-caboxymethylbenzothiazolium bromide (NK5962) was covalently immobilized to an indium tin oxide (ITO) and 3-(aminopropyl) trimethoxysilane (APTMS) surface. The NK562 derivatized surface was characterized through contact angle goniometry, electrochemical impedance spectroscopy, grazing angle infrared spectroscopy, and ultraviolet-visible absorption spectrophotometry. NG108-15 neurons were differentiated onto the surface and neural responses from electrical stimulation and photostimulation of the system were measured using whole-cell current and voltage clamp methodologies. We found an average 2.9 mV decrease in NG108-15 threshold potential for every 10 mV increase in ITO surface potential. Following photostimulation, there was a 1.8±0.2 fold increase (p
Age-related Macular Degeneration Diagnosis and Treatment
Author: Allen C. Ho
Publisher: Springer Science & Business Media
Published: 2011-08-09
Total Pages: 194
ISBN-13: 1461401259
DOWNLOAD EBOOKAge-Related Macular Degeneration: Diagnosis and Treatment is written by two leading experts from Wills Eye Hospital. Covering the latest therapies and treatments developed in the last few years, this is a concise yet highly illustrated and practical text that guides the clinician through diagnosis and treatment of the leading cause of blindness in older Americans.
Handbook of Clinical Electrophysiology of Vision
Author: Minzhong Yu
Publisher: Springer Nature
Published: 2019-12-26
Total Pages: 218
ISBN-13: 3030304175
DOWNLOAD EBOOKThis book provides an analytical and thorough review of clinical electrophysiology of vision, and the progress made in the field in the past decade. Handbook of Clinical Electrophysiology of Vision is designed to aid the readers in understanding the types of electrophysiologic tests that should be used in specific diseases, how to explain the results of these exams, and how to perform the tests of clinical electrophysiology of vision. Concise in format, the Handbook of Clinical Electrophysiology of Vision is divided into two sections that discuss a wide range of relevant topics, such as technology of electroretinography, electrooculography, visual evoked potential, characteristics of electroretinography in retinal diseases, and the characteristics of optic nerve diseases. Part one begins with a discussion on the basic theory of electrophysiology of vision, illustrating physiologic sources of electrophysiological responses, the techniques of the recording, and analysis of electrophysiologic signals. Part two then dives into the clinical application of electrophysiology of vision, and subsequently summarizes the characteristics of the electrophysiological signals in a number of disorders of retina and optic nerve. Written by experts in the field, Handbook of Clinical Electrophysiology of Vision is an invaluable resource for ophthalmologists, optometrists, electrophysiologists, residents, fellows, researchers, technicians and students in ophthalmology, optometry and vision science.
Age-Related Macular Degeneration
Author: Giuseppe Lo Giudice
Publisher: BoD – Books on Demand
Published: 2013-06-12
Total Pages: 203
ISBN-13: 9535111132
DOWNLOAD EBOOKAge-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in developed countries.There have been rapid developments of therapies that today can halt or even reverse aspects of vision loss resulting from AMD among those most severely affected, and there is promise of future therapies that may prevent vision loss. This book provides an overview about AMD; an update on the current understanding of AMD, pathophysiology, the use of diagnostic tests, the management of both non-neovascular and neovascular AMD as well as future directions in treatment and its limitations. It also looks into the future with potential treatment options that are now under investigation in clinical trials.
Clinical Retina
Author: David A. Quillen
Publisher: American Medical Association Press
Published: 2002
Total Pages: 424
ISBN-13:
DOWNLOAD EBOOKEach condition in this book is presented in a standard format including general information, symptoms, clinical features, ancillary tests, pathology, treatment, systematic evaluation and selected references.
