Effects of Time-Varying Magnetic Fields in the Frequency Range 1 KHz to 100 KHz Upon the Human Body
Effects of Time-Varying Magnetic Fields in the Frequency Range 1 KHz to 100 KHz Upon the Human Body

Author: Julia Bohnert

Publisher: KIT Scientific Publishing

Published: 2014-05-12

Total Pages: 203

ISBN-13: 3866447825

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In this work, the physiological effects of time-varying magnetic fields up to 100 kHz have been investigated, namely magnetic stimulation and body warming. Simulation studies were based on numerical calculations on sophisticated cell and body models. In addition, magnetic stimulation thresholds have been determined experimentally.The project was carried out within the scope of the development of Magnetic Particle Imaging, a new imaging technology for medical diagnostics.

5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary
5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary

Author: Ákos Jobbágy

Publisher: Springer Science & Business Media

Published: 2012-02-02

Total Pages: 1477

ISBN-13: 3642235085

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This volume presents the 5th European Conference of the International Federation for Medical and Biological Engineering (EMBEC), held in Budapest, 14-18 September, 2011. The scientific discussion on the conference and in this conference proceedings include the following issues: - Signal & Image Processing - ICT - Clinical Engineering and Applications - Biomechanics and Fluid Biomechanics - Biomaterials and Tissue Repair - Innovations and Nanotechnology - Modeling and Simulation - Education and Professional

Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves
Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves

Author: Loewe, Axel

Publisher: KIT Scientific Publishing

Published: 2016-08-03

Total Pages: 342

ISBN-13: 3731505282

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Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF.

ECG Based Analysis of the Ventricular Repolarisation in the Human Heart
ECG Based Analysis of the Ventricular Repolarisation in the Human Heart

Author: Baas, Tobias

Publisher: KIT Scientific Publishing

Published: 2012-08-06

Total Pages: 260

ISBN-13: 3866448821

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ECG recordings provide diagnostic relevant information on the de- and repolarisation sequences of the heart. A modification of the repolarisation sequence is assumed to cause Torsades de Pointes. Especially drug induced effects on the repolarisation processes are in focus, since some non-cardiac drugs have been associated with sudden cardiac death in the 1990s.The analysis of the ventricular repolarisation using a set of parameters depicting the morphology of the T-wave is introduced in this work. Therefore, new methods of fully automatic patient-specific QRS detection, beat classification and precise T-wave delineation are presented. Using these methods, medical studies are investigated regarding the modification of the T-wave by different compounds. Also the impact of the heart rate on the morphology of the T-wave is part of this research.The reliable identification of ventricular ectopic beats allows an analysis of the influence of these beats on subsequent heart beats. It turned out that the morphology of subsequent heart beats can significantly be changed. This might give new information on the proarrythmical risk of ventricular ectopic beats.

Personalized Multi-Scale Modeling of the Atria: Heterogeneities, Fiber Architecture, Hemodialysis and Ablation Therapy
Personalized Multi-Scale Modeling of the Atria: Heterogeneities, Fiber Architecture, Hemodialysis and Ablation Therapy

Author: Martin Wolfgang Krüger

Publisher: KIT Scientific Publishing

Published: 2014-05-22

Total Pages: 320

ISBN-13: 3866449488

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This book targets three fields of computational multi-scale cardiac modeling. First, advanced models of the cellular atrial electrophysiology and fiber orientation are introduced. Second, novel methods to create patient-specific models of the atria are described. Third, applications of personalized models in basic research and clinical practice are presented. The results mark an important step towards the patient-specific model-based atrial fibrillation diagnosis, understanding and treatment.

ECG Imaging of Ventricular Activity in Clinical Applications
ECG Imaging of Ventricular Activity in Clinical Applications

Author: Schulze, Walther H. W.

Publisher: KIT Scientific Publishing

Published: 2015-08-12

Total Pages: 238

ISBN-13: 3731503743

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ECG imaging was performed in humans to reconstruct ventricular activation patterns and localize their excitation origins. The precision of the non-invasive reconstructions was evaluated against invasive measurements and found to be in line with the state-of-the-art literature. Statistics were produced for various excitation origins and reveal the beat-to-beat robustness of the imaging method.

Formation of Intracardiac Electrograms under Physiological and Pathological Conditions
Formation of Intracardiac Electrograms under Physiological and Pathological Conditions

Author: Keller, Matthias

Publisher: KIT Scientific Publishing

Published: 2014-09-09

Total Pages: 264

ISBN-13: 3731502283

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This work presents methods to advance electrophysiological simulations of intracardiac electrograms (IEGM). An experimental setup is introduced, which combines electrical measurements of extracellular potentials with a method for optical acquisition of the transmembrane voltage in-vitro. Thereby, intracardiac electrograms can be recorded under defined conditions. Using experimental and clinical signals, detailed simulations of IEGMs are parametrized, which can support clinical diagnosis.

Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment
Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment

Author: Mathias Wilhelms

Publisher: KIT Scientific Publishing

Published: 2014-05-22

Total Pages: 206

ISBN-13: 3731500450

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Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.

Analysis of Atrial Electrograms
Analysis of Atrial Electrograms

Author: Christopher Schilling

Publisher: KIT Scientific Publishing

Published: 2012

Total Pages: 240

ISBN-13: 3866448945

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This work provides methods to measure and analyze features of atrial electrograms - especially complex fractionated atrial electrograms (CFAEs) - mathematically. Automated classification of CFAEs into clinical meaningful classes is applied and the newly gained electrogram information is visualized on patient specific 3D models of the atria. Clinical applications of the presented methods showed that quantitative measures of CFAEs reveal beneficial information about the underlying arrhythmia.

SAR Prediction and SAR Management for Parallel Transmit MRI
SAR Prediction and SAR Management for Parallel Transmit MRI

Author: Hanno Homann

Publisher: KIT Scientific Publishing

Published: 2014-07-30

Total Pages: 146

ISBN-13: 3866448007

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Parallel transmission enables control of the RF field in high-field Magnetic Resonance Imaging (MRI). However, the approach has also caused concerns about the specific absorption rate (SAR) in the patient body. The present work provides new concepts for SAR prediction. A novel approach for generating human body models is proposed, based on a water-fat separated MRI pre-scan. Furthermore, this work explores various approaches for SAR reduction.