Orthopaedic Knowledge Update 13: Ebook without Multimedia
Orthopaedic Knowledge Update 13: Ebook without Multimedia

Author: Javad Parvizi

Publisher: Lippincott Williams & Wilkins

Published: 2020-01-13

Total Pages: 1266

ISBN-13: 1975135512

DOWNLOAD EBOOK

Orthopaedic Knowledge Update 13 brings you a comprehensive synthesis of the latest clinical thinking and best practices across all orthopaedic specialty areas. Backed by clinical research, informed by practical experience, and rigorously edited by specialty thought leaders, OKU 13 is the most up-to-date resource available anywhere for delivering high-quality orthopaedic patient care today. Keep pace with the rapidly changing body of orthopaedic knowledge and clinical practice with OKU’s objective and balanced coverage.

Enhanced Bone Healing with BCP Granules Implanted with BMP-2 and MSCs in a Rabbit Calvarial Defect
Enhanced Bone Healing with BCP Granules Implanted with BMP-2 and MSCs in a Rabbit Calvarial Defect

Author: Sun-Sik Yang

Publisher:

Published: 2017

Total Pages:

ISBN-13:

DOWNLOAD EBOOK

The aim of this study was to evaluate the in vivo osteogenic potential of biphasic calcium phosphate (BCP), bone morphogenetic protein 2 (BMP-2), and/or mesenchymal stem cell (MSC) composites by using a rabbit calvarial defect model. Bone formation was assessed by using three different kinds of implants in rabbit calvarial defects, BCP alone, BCP/recombinant human (rh) BMP-2, and BCP/rhBMP-2/MSCs composite. The implants were harvested after 2 or 8 weeks, and the area of new bone formation was quantified by micro-computed tomography (micro-CT) and histologic studies. The highest bone formation was achieved with the BCP/rhBMP-2/MSCs treatment, and it was significantly higher than that achieved with the empty or BCP-alone treatment. The quantity of new bone at 8 weeks was greater than at 2 weeks in each group. The relative density of osteocalcin immunoreactivity also increased during this interval. These results indicate that the combination of BCP, rhBMP-2, and MSCs synergistically enhances osteogenic potential during the early healing period and could be used as a bone graft substitute.

Developments and Applications of Calcium Phosphate Bone Cements
Developments and Applications of Calcium Phosphate Bone Cements

Author: Changsheng Liu

Publisher: Springer

Published: 2017-10-20

Total Pages: 632

ISBN-13: 9811059756

DOWNLOAD EBOOK

This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.

An Evaluation of Healing in Critical Sized Rabbit Calvarial Defects Using Modified Bone Substitutes [microform]
An Evaluation of Healing in Critical Sized Rabbit Calvarial Defects Using Modified Bone Substitutes [microform]

Author: Albert Jason Haddad

Publisher: Library and Archives Canada = Bibliothèque et Archives Canada

Published: 2004

Total Pages: 202

ISBN-13: 9780612953154

DOWNLOAD EBOOK

Limitations of autogenous bone have led to the development of bone substitutes. This study evaluated whether the use of LactosorbRTM and/or calcium phosphate cements as carriers for these osteoinductive materials would allow for bone regenerative. This investigation attempted to address the issues of providing immediate protection of the brain while at the same time allowing for progressive filling of the defect with bone using two strategies. The combination of Lactosorb RTM and DBM putty demonstrated defect closure identical to the autogenous bone control group. These results suggest that these novel combinations of bone regenerative substitutes have the ability to replace our dependence on autogenous bone grafting. Thirty rabbits were divided into 3 groups. Group 1 had autogenous bone placed in one defect while the other defect remained unfilled. Group 2 had one defect filled with DBM putty and the other remained empty while a Lactosorb RTM covered both defects. Group 3 had MimixRTM, a calcium phosphate cement, placed in one defect while the other was filled with CPC/BMP.