Drug-Induced Mitochondrial Dysfunction
Drug-Induced Mitochondrial Dysfunction

Author: James A. Dykens

Publisher: Wiley-Interscience

Published: 2008-09-22

Total Pages: 0

ISBN-13: 9780470111314

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This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.

Drug-Induced Mitochondrial Dysfunction
Drug-Induced Mitochondrial Dysfunction

Author: James A. Dykens

Publisher: John Wiley & Sons

Published: 2008-09-11

Total Pages: 648

ISBN-13: 0470372524

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This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Author: Yvonne Will

Publisher: John Wiley & Sons

Published: 2018-03-23

Total Pages: 816

ISBN-13: 1119329744

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Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Author: Yvonne Will

Publisher: John Wiley & Sons

Published: 2018-03-21

Total Pages: 813

ISBN-13: 1119329736

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Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Mitochondrial Dysfunction
Mitochondrial Dysfunction

Author: Lawrence H. Lash

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 527

ISBN-13: 1483218619

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Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Drug-Induced Liver Injury
Drug-Induced Liver Injury

Author:

Publisher: Academic Press

Published: 2019-07-13

Total Pages: 288

ISBN-13: 0128173173

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Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Adverse Drug Reactions
Adverse Drug Reactions

Author: Jack Uetrecht

Publisher: Springer Science & Business Media

Published: 2009-12-18

Total Pages: 552

ISBN-13: 3642006639

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This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal.

Toxicology Studies
Toxicology Studies

Author: Ana Cristina Andreazza

Publisher: BoD – Books on Demand

Published: 2015-07-08

Total Pages: 246

ISBN-13: 9535121405

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The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed. Since the bioactivation of many toxins and toxicants and its consequences on human health are not clearly known, this book offers a quick overview of cellular toxicology through the cell, drug and environmental toxicity. This book does not strive to be comprehensive but instead offers a quick overview of principle aspects of toxins and toxicants in order to familiarize the key principles of toxicology. The book is divided into three main sections,; the first one discusses the role of mitochondrial dysfunction, oxidative stress and mitochondrial drug development. The second and third sections bring light to forensic toxicology and drug poisoning followed by environmental toxicity.

Mitochondrial DNA and Diseases
Mitochondrial DNA and Diseases

Author: Hongzhi Sun

Publisher: Springer

Published: 2017-11-25

Total Pages: 233

ISBN-13: 9811066744

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The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.