"These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project. " - p. iv
Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes
A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs, cardiovascular drugs, antibiotics, and NSAIDs. For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. Environmental and social pharmacological issues are also addressed in chapters on food and alcohol drug interactions, nicotine and tobacco, and anabolic doping agents. Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.
Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.
The quick reference guide you need to avoid harmful interactions between prescription drugs, over-the-counter medications, and dietary supplements Drug Actions and Interactions is a handy easy-to-access guide to understanding what major drugs are available for specific diseases, how selected drugs produce therapeutic benefits, side effects that may occur when taking these drugs, and which drugs and supplements should not be taken in combination with each other. Applying the 300 most often prescribed drugs in the United States to more than 80 common disorders, Drug Actions and Interactions discusses each drug’s mechanism of action, side effects, and drug interactions. Molecular structures of medications are also included to help you understand their mechanisms of action. Coverage includes drugs that act on the major systems (cardiovascular, respiratory, gastrointestinal, genitourinary, endocrine, neuronal); bone, muscle, skin, and joints; and general health. You will also find an appendix listing major drugs currently in use in each therapeutic classification. Thirty-two additional appendices detail interaction between a therapeutic group of drugs and an individual drug or group of drugs, such as interactions of beta-blockers, alpha-blockers, calcium-blockers, etc.
Thoroughly updated for its Third Edition, this handbook provides complete, current, and easily accessible information on how psychotropic drugs interact with one another and with compounds used to treat non-psychiatric medical conditions. The book is organized for rapid reference, includes numerous tables, and offers guidelines for managing adverse effects. The Third Edition includes an adverse drug effects table in the appendix section, tables on receptor binding and dosing, and the latest information on drugs of abuse and chemical dependence. This edition also includes drug-food interactions for each drug category and interactions of psychotropic drugs with HIV medications.
Presenting detailed, evidence-based coverage of the most commonly encountered therapeutic agents in modern clinical practice, this resource is designed to help you safely and effectively integrate herbal, nutrient, and drug therapy for your patients or clients. Combining pharmaceuticals with herbs or supplements may complement or interfere with a drug's therapeutic action or may increase adverse effects. Additionally, drug-induced depletion of nutrients can occur. Comprehensive clinical data, quick-reference features, and the insight and expertise of trusted authorities help you gain a confident understanding of how herbal remedies and nutritional supplements interact with pharmaceuticals and develop safe, individualized treatment strategies for your patients. More than 60 comprehensive monographs of herb-drug and nutrient-drug interactions cover the most commonly used herbs and nutrients in health-related practice and help you coordinate safe, reliable therapy. Each herb and nutrient monograph features summary tables and concise, practical suggestions that provide quick and easy reference and complement the systematic review and in-depth analysis. References included on the bound-in CD provide high-quality, evidence-based support. Unique icons throughout the text differentiate interactions, evidence, and clinical significance. Up-to-date information keeps you current with the latest developments in pharmacology, nutrition, phytotherapy, biochemistry, genomics, oncology, hematology, naturopathic medicine, Chinese medicine, and other fields. A diverse team of authoritative experts lends valuable, trans-disciplinary insight.
The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook. The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to anesthesiologists and surgeons, as well as trainees in both specialties; intensive care staff, including physicians, physician’s assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics.
