With a focus on improving diagnosis and treatment, Drug Allergy Testing is your new go-to resource for understanding various drug allergies and testing methods, the epidemiology of and economic impact of drug allergies, and new drug and allergy developments. - Features a wealth of up-to-date information for allergists, immunologists, and primary care physicians who diagnose and treat patients with drug allergies and hypersensitivity. - Covers the basics of drug allergy evaluation and management as well as specific drugs including antibiotics, ASA/NSAIDs, chemotherapeutic agents and monoclonal antibodies.
The variety of chemically diverse pharmacological agents administered to patients is large and continues to expand and with every new drug released, there is always potential for adverse reactions, some of them allergic. With its roots in immunology and pharmacology, the science of drug allergy is becoming better understood and applied as its importance is increasingly recognized throughout the many branches of medicine. Drug Allergy: Clinical Aspects, Diagnosis, Mechanisms, Structure-Activity Relationships sheds new light on this field. Comprehensive in design, this authoritative title identifies the most important culprit drugs implicated in immediate and delayed drug hypersensitivities and offers up-to-date information on classifications, diagnoses, underlying mechanisms and structure-activity relationships. Chapters dealing with the molecular and cellular mechanisms of drug hypersensitivities, non-immune-mediated sensitivities and diagnostic methods are presented as introductory material for in-depth treatises on the β-lactam antibiotics, other antibiotics and antimicrobials, drugs used in anesthesia and surgery, opioid analgesics, corticosteroids, monoclonal antibodies and other biologics, drugs used in chemotherapy, proton pump inhibitors, iodinated and gadolinium-based contrast media and non-steroidal anti-inflammatory drugs. In addition to being of immense value to clinicians, other health care professionals and researchers, this title will prove invaluable for those taking undergraduate and graduate courses in science and will also serve as a useful text for students of medicine, pharmacy, nursing and dentistry.
Approaches the phenomenon of drug hypersensitivity in a comprehensive manner. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in this book. The book also covers clinical manifestations and new diagnostic methods, and introduces some recetly established animal models. Many topics are treated from multiple perspectives, and the 33 chapters are thoroughly cross-referenced.
This best-selling resource has a worldwide reputation as the leader in its field. Focusing on human immunology and biology, while also reporting on scientific experimentation and advancement, it provides comprehensive coverage of state-of-the-art basic science as well as authoritative guidance on the practical aspects of day-to-day diagnosis and management. This new edition includes 700 full-color illustrations and a new, more accessible format to make finding information a snap for the busy practitioner. And this Expert Consult Edition offers online access to the complete contents of the 2-volume set, fully searchable, and much more. Includes a glossary of allergy and immunology for quick and easy reference. Contains keypoints and clinical pearls highlighted to find important information quickly. links to useful online resources both for you and for your patients. Offers contributions from hundreds of international authorities for world-class expertise in overcoming any clinical challenge.
This fourth volume in an exciting and detailed series on contact allergens and drug allergy provides monographs of all 507 systemic drugs which have caused delayed-type cutaneous drug hypersensitivity reactions and/or occupational allergic contact dermatitis. The monographs present: Identification section; Occupational allergic contact dermatitis; and Cutaneous adverse drug reactions from systemic drugs caused by type IV (delayed-type) hypersensitivity, as shown by positive patch tests (e.g. maculopapular eruption, acute generalized exanthematous pustulosis [AGEP], symmetrical drug-related intertriginous and flexural exanthema [SDRIFE], fixed drug eruption, drug reaction with eosinophilia and systemic symptoms [DRESS], and photosensitivity). Separate chapters present an overview of the spectrum of allergic cutaneous drug reactions, diagnostic tests, immediate contact reactions (contact urticaria), and systemic drugs that have acquired delayed-type hypersensitivity only by cross-reactivity. Key Features: Presents monographs of all known systemic drugs which have caused delayed allergic cutaneous drug reactions and/or occupational allergic contact dermatitis Provides an extensive literature review of relevant topics of allergenic systemic drugs, part of which is hard or impossible to find in database searches Identifies IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing Presents immediate contact reactions (contact urticaria) from systemics drugs and delayed-type hypersensitivity in drugs caused only by cross-reactivity Covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy
Internationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions, Litt’s Drug Eruption & Reaction Manual is a succinct clinical reference and essential drug-safety tool for patient care. This 27th edition is a comprehensively revised and updated quick reference, and each entry includes: * Quantitative summaries of reports and incidence for reactions * Drug–drug interactions * Categories of adverse drug reactions, eruptions, and cutaneous reaction patterns * Essential reference information on prescription and over-the-counter drugs as well as herbals and supplements The book contains... * A to Z listing of the 1500 most consulted drug and herbal profiles, including generic name and trade names; pharmaceutical company; indications; half-life; and pregnancy category * Over 31,000 adverse reactions and drug-eruption listings * Includes supplements, vaccines, and botanicals * Clinical definitions of common and severe adverse reactions * List of drugs that cause severe adverse reactions * List of main classes of drugs as a quick clinical reference guide * 27 tables of members of a class of drugs (such as statins or monoclonal antibodies), enabling clinicians to see at a glance whether a reaction is common to all drugs included in that class, or to a majority of them, or is known in only a handful—information that is critical for an informed decision to change drugs within the same class * 2 extensive tables showing reported genetic associations with cutaneous adverse drug reactions and recommendations regarding genetic screening to prevent cutaneous adverse drug reactions * A concordance of synonyms and trade names for ease of cross-reference Markets: Dermatologists, Neurologists, Oncologists, Psychiatrists, Pharmacists, Family Physicians, and those caring for patients on multiple medications, such as Geriatricians and Hospital Generalist Physicians. Litt’s Drug Eruption & Reaction Manual is a succinct clinical reference derived from Litt’s Drug Eruption & Reaction Database, located at www.drugeruptiondata.com, which currently holds over 1750 drug profiles with almost 70,000 documented drug reactions, as evidenced by well over 145,000 references on PubMed. Quick and easy access via the Litt app provides real time access to the most up-to-date drug safety information to a busy practitioner on-the-go. Subscribers to the database benefit from: * Easy access via the Litt app, ideal for working across a number of work-places * Full drug profiles with a wealth of information including category, half-life, indications, drug-drug interactions, and known adverse reactions * Links to PubMed abstracts * Searching a class of drugs for a specific reaction * Searching by adverse reaction pattern * Searching by indication for a drug * Searching by drug name (generic name/brand name) as well as by pharmaceutical company or drug class * Searching herbal medicines and supplements * Diagnosing the cause of reactions in patients on multiple drugs by selecting the adverse reaction(s) experienced and the drug(s) the patient is taking * Comparing reaction profiles for up to four drugs in a customized chart that can be saved for future reference * Descriptions of reaction patterns * Photographs of adverse reactions * Access via a computer, tablet, or smartphone * Regular updates To learn more, and to subscribe to the database, visit www.drugeruptiondata.com.
According to most studies, allergic reactions represent 35%-50% of all untoward reactions to drugs, yet the pharmacological literature concerning the clinical aspects, diagnosis, and pathophysiological mechanisms of drug allergy is markedly less extensive than reports dealing with the toxicological or pharmacological effects of drugs. The main reasons for this state of affairs may be on the one hand that until a few years ago the pathophysiological mechanisms of the various types of allergic reactions were not well understood, and on the other hand that objective diagnosis of a drug allergy is still fraught with serious difficulties. Drug allergy is still an unpopular topic for most allergologists and pharmacologists; this is reflected by the fact that despite their frequency, allergic reactions to drugs still occupy a relatively small proportion of space in most pharmacology handbooks and in classical books devoted to the side effects of drugs. There has recently been considerable progress in research into the immunologi cal and pathophysiological events occurring in allergic reactions, and on that basis investigations of various drug allergies have also yield̃d new objective findings. Consequently, it was natural to attempt a review of the most frequent and important drug allergies in the form of a handbook. We originally intended to present a comprehensive review of all drug allergies, but the realization of this goal soon became more difficult than we had at first imagined.
Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.
This is the perfect pharmacology textbook for medical and pharmacy students. The book was developed on the +30-year experience of the author as pharmacology professor in the United States and Germany. The book discusses the most important drugs (400) in the context of relevant diseases. Summary tables and schemes, MCQ exam questions, case studies and a list of drugs aid memorization of the material before an exam. All chapters are written in the same concise style and use a modern and precise pharmacological nomenclature. After reading of the book, the student will be able to critically assess the proper use of the most important drugs and advise patients properly. The didactic concept of the book has been developed on the author’s own pharmacology courses for which he has received numerous teaching awards. The book takes advantage of the learning spiral, in which material is presented repeatedly from various angles. This book is an adaptation for an international audience of the German textbook “Basiswissen Pharmakologie” (2018); ISBN: 978-3-662-56303-8.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
