Phenylketonuria (PKU) is the leading biochemical cause for mental retardation in children. The study suggests levels of tyrosine reaching the brain are directly relational to the cognitive functions in the prefrontal cortex.
The only book that covers the multiple ways in which ADHD is complicated by other psychiatric and learning disorders in both children and adults, ADHD Comorbidities: Handbook for ADHD Complications in Children and Adults features comprehensive, research-based information on ADHD and its full range of coexisting syndromes. Contributing researcher-clinicians, familiar with the complications that additional disorders pose, summarize in accessible language what is currently known about ADHD and its comorbidities, from preschool age to adulthood. These authors describe how ADHD leads to different profiles at different stages of development and how to adjust treatment strategies for both ADHD and additional disorders to reduce the impairments resulting from their combination. The book offers a new paradigm for understanding ADHD, viewing it not as a simple behavior disorder but as a complex developmental impairment of executive functions in the brain. This important handbook gives developmental context to ADHD by describing how symptoms at preschool onset differ from those of older age at onset. Clinicians will find practical help for patients whose ADHD appears in conjunction with 11 other syndromes -- from mood disorders to developmental coordination disorder -- and acquire valuable guidance on adapting and adjusting medications and other interventions to optimize treatment effects for the wide diversity of complex cases that embody ADHD.
Widely regarded as the standard clinical reference, this volume provides the best current knowledge about attention-deficit/hyperactivity disorder (ADHD) in children, adolescents, and adults. The field's leading authorities address all aspects of assessment, diagnosis, and treatment, including psychological therapies and pharmacotherapy. Core components of ADHD are elucidated. The volume explores the impact of the disorder across a wide range of functional domains--behavior, learning, psychological adjustment, school and vocational outcomes, and health. All chapters conclude with user-friendly Key Clinical Points. New to This Edition *Reflects significant advances in research and clinical practice. *Expanded with many new authors and new topics. *Chapters on cutting-edge interventions: social skills training, dietary management, executive function training, driving risk interventions, complementary/alternative medicine, and therapies for adults. *Chapters on the nature of the disorder: neuropsychological aspects, emotional dysregulation, peer relationships, child- and adult-specific domains of impairment, sluggish cognitive tempo, and more.
The Frontal Lobes, Volume 163, updates readers on the latest thinking on the structure and function of the human frontal lobe. Sections address methodology, anatomy, physiology and pharmacology, function, development, aging and disorders, and rehabilitation. Patients with focal lesions in the frontal lobes have long been studied to reveal the organization and function of the frontal lobes. Over the last two decades, studies of patients with neurodegenerative diseases and developmental disorders have increased, with new findings discussed in this volume. In addition, the book includes discussions on genetics and molecular biology, optogenetics, high-resolution structural and functional neuroimaging and electrophysiology, and more. Lastly, new knowledge on the biology, structure and function of the frontal lobes, new treatment targets for pharmacology, non-invasive brain stimulation, and cognitive/social remediation are presented. The last section covers new efforts that will hopefully lead to better outcomes in patients with frontal lobe disorders. - Provides an overview of the structure, function, disorder and rehabilitation of the frontal lobes - Addresses a wide variety of methodologies – from genetics and molecular biology, to optogenetics and hi-res fMRI, and more - Contains content of interest to advanced students, junior researchers and clinicians getting involved in research - Features the input of leaders in neuroanatomical research from around the globe – the broadest, most expert coverage available
Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.
Since its first publication in 1979, Clinical Neuropsychology has been a valued resource for students and scientists interested in brain-behavior relationships. The text covers all of the major syndromes, but reflects the major advances in understanding and treatment of neurobehavioral disorders since the previous edition was published.
Here is the state-of-the-art on recognizing, managing and living with neurofibromatosis (NF) for patients, families, and health care professionals. From new genetic and diagnostic advances, to associated cardiovascular and endocrine abnormalities, to the significant psychosocial impact of NF, the book is packed with clear, practical guidance for understanding and living with this disability.Special features: A complete diagnostic guide to help you recognize NF-related symptoms--with a timeline for when they might appear New treatment options for NF, including pain control Coverage of the newly discovered form of NF, schwannomatosis Personal perspectives from NF patients and their families Glossary that defines medical terminology With the great diagnostic and treatment advances achieved in the last decade, and research proceeding rapidly, the future for patients with NF has never been brighter. For all individuals living with the challenges of this disability, the book brings you to the forefront of medical knowledge. Make sure it is within close reach for fast and easy reference.
Synthesizing a wealth of recent neuropsychological research, this groundbreaking book focuses on the multiple pathways by which attention-deficit/hyperactivity disorder (ADHD) develops. Joel T. Nigg marshals the best available knowledge on what is actually going on in the symptomatic child's brain and why, tracing the intersecting causal influences of genetic, neural, and environmental factors. In the process, the book confronts such enduring controversies as the validity of ADHD as a clinical construct. Specific suggestions are provided for studies that might further refine the conceptualization of the disorder, with significant potential benefits for treatment and prevention.