Differential Equations for Studies in Computational Electrophysiology
Differential Equations for Studies in Computational Electrophysiology

Author: Karoline Horgmo Jæger

Publisher: Springer Nature

Published: 2023-05-27

Total Pages: 134

ISBN-13: 3031308522

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This open access text aims at giving you the simplest possible introduction to differential equations that are used in models of electrophysiology. It covers models at several spatial and temporal scales with associated numerical methods. The text demonstrates that a very limited number of fundamental techniques can be used to define numerical methods for equations ranging from ridiculously simple to extremely complex systems of partial differential equations. Every method is implemented in Matlab and the codes are freely available online. By using these codes, the reader becomes familiar with classical models of electrophysiology, like the cable equation, the monodomain model, and the bidomain model. But modern models that have just started to gain attention in the field of computational electrophysiology are also presented. If you just want to read one book, it should probably not be this one, but if you want a simple introduction to a complex field, it is worth considering the present text.

Computational Science and Its Applications – ICCSA 2023 Workshops
Computational Science and Its Applications – ICCSA 2023 Workshops

Author: Osvaldo Gervasi

Publisher: Springer Nature

Published: 2023-06-28

Total Pages: 781

ISBN-13: 3031371054

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This nine-volume set LNCS 14104 – 14112 constitutes the refereed workshop proceedings of the 23rd International Conference on Computational Science and Its Applications, ICCSA 2023, held at Athens, Greece, during July 3–6, 2023. The 350 full papers and 29 short papers and 2 PHD showcase papers included in this volume were carefully reviewed and selected from a total of 876 submissions. These nine-volumes includes the proceedings of the following workshops: Advances in Artificial Intelligence Learning Technologies: Blended Learning, STEM, Computational Thinking and Coding (AAILT 2023); Advanced Processes of Mathematics and Computing Models in Complex Computational Systems (ACMC 2023); Artificial Intelligence supported Medical data examination (AIM 2023); Advanced and Innovative web Apps (AIWA 2023); Assessing Urban Sustainability (ASUS 2023); Advanced Data Science Techniques with applications in Industry and Environmental Sustainability (ATELIERS 2023); Advances in Web Based Learning (AWBL 2023); Blockchain and Distributed Ledgers: Technologies and Applications (BDLTA 2023); Bio and Neuro inspired Computing and Applications (BIONCA 2023); Choices and Actions for Human Scale Cities: Decision Support Systems (CAHSC-DSS 2023); and Computational and Applied Mathematics (CAM 2023).

Computational Models of Brain and Behavior
Computational Models of Brain and Behavior

Author: Ahmed A. Moustafa

Publisher: John Wiley & Sons

Published: 2017-09-18

Total Pages: 845

ISBN-13: 1119159180

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A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.

Mathematical Cardiac Electrophysiology
Mathematical Cardiac Electrophysiology

Author: Piero Colli Franzone

Publisher: Springer

Published: 2014-10-30

Total Pages: 410

ISBN-13: 3319048015

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This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.

Mathematical and Computational Approaches in Advancing Modern Science and Engineering
Mathematical and Computational Approaches in Advancing Modern Science and Engineering

Author: Jacques Bélair

Publisher: Springer

Published: 2016-08-10

Total Pages: 777

ISBN-13: 3319303791

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Focusing on five main groups of interdisciplinary problems, this book covers a wide range of topics in mathematical modeling, computational science and applied mathematics. It presents a wealth of new results in the development of modeling theories and methods, advancing diverse areas of applications and promoting interdisciplinary interactions between mathematicians, scientists, engineers and representatives from other disciplines. The book offers a valuable source of methods, ideas, and tools developed for a variety of disciplines, including the natural and social sciences, medicine, engineering, and technology. Original results are presented on both the fundamental and applied level, accompanied by an ample number of real-world problems and examples emphasizing the interdisciplinary nature and universality of mathematical modeling, and providing an excellent outline of today’s challenges. Mathematical modeling, with applied and computational methods and tools, plays a fundamental role in modern science and engineering. It provides a primary and ubiquitous tool in the context making new discoveries, as well as in the development of new theories and techniques for solving key problems arising in scientific and engineering applications. The contributions, which are the product of two highly successful meetings held jointly in Waterloo, Ontario, Canada on the main campus of Wilfrid Laurier University in June 2015, i.e. the International Conference on Applied Mathematics, Modeling and Computational Science, and the Annual Meeting of the Canadian Applied and Industrial Mathematics (CAIMS), make the book a valuable resource for any reader interested in a broader overview of the methods, ideas and tools involved in mathematical and computational approaches developed for other disciplines, including the natural and social sciences, engineering and technology.

Modeling Excitable Tissue
Modeling Excitable Tissue

Author: Aslak Tveito

Publisher: Springer Nature

Published: 2020-10-30

Total Pages: 116

ISBN-13: 3030611574

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This open access volume presents a novel computational framework for understanding how collections of excitable cells work. The key approach in the text is to model excitable tissue by representing the individual cells constituting the tissue. This is in stark contrast to the common approach where homogenization is used to develop models where the cells are not explicitly present. The approach allows for very detailed analysis of small collections of excitable cells, but computational challenges limit the applicability in the presence of large collections of cells.

Numerical Solution of Partial Differential Equations on Parallel Computers
Numerical Solution of Partial Differential Equations on Parallel Computers

Author: Are Magnus Bruaset

Publisher: Springer Science & Business Media

Published: 2006-03-05

Total Pages: 491

ISBN-13: 3540316191

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Since the dawn of computing, the quest for a better understanding of Nature has been a driving force for technological development. Groundbreaking achievements by great scientists have paved the way from the abacus to the supercomputing power of today. When trying to replicate Nature in the computer’s silicon test tube, there is need for precise and computable process descriptions. The scienti?c ?elds of Ma- ematics and Physics provide a powerful vehicle for such descriptions in terms of Partial Differential Equations (PDEs). Formulated as such equations, physical laws can become subject to computational and analytical studies. In the computational setting, the equations can be discreti ed for ef?cient solution on a computer, leading to valuable tools for simulation of natural and man-made processes. Numerical so- tion of PDE-based mathematical models has been an important research topic over centuries, and will remain so for centuries to come. In the context of computer-based simulations, the quality of the computed results is directly connected to the model’s complexity and the number of data points used for the computations. Therefore, computational scientists tend to ?ll even the largest and most powerful computers they can get access to, either by increasing the si e of the data sets, or by introducing new model terms that make the simulations more realistic, or a combination of both. Today, many important simulation problems can not be solved by one single computer, but calls for parallel computing.

Artificial Intelligence for Computational Modeling of the Heart
Artificial Intelligence for Computational Modeling of the Heart

Author: Tommaso Mansi

Publisher: Academic Press

Published: 2019-11-28

Total Pages: 274

ISBN-13: 012817594X

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Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient's heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications.