Dibenzanthracenes and Environmental Carcinogenesis
Dibenzanthracenes and Environmental Carcinogenesis

Author: Walter Karcher

Publisher: Cambridge University Press

Published: 1992-10-15

Total Pages: 296

ISBN-13: 9780521303828

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A systematic survey of the dibenzanthracenes and of their chemical, physiochemical, and biological properties, this book treats the nomenclature, the chemical and physical properties, and the synthesis and preparation of the five principal isomers of the dibenzanthracene series: dibenz (a, h), dibenz (a, c), dibenz (a, j), anthracene, benzo(a)naphthacene, and pentacene. Other chapters are devoted to their occurrence and analysis in the environment, in industrial processes and effluents, and in foodstuffs. T second part addresses their biological activity and reviews the metabolism, cellular interactions, toxicology, mutagenicity, and carcinogenicity of the dibenzanthracenes. The final chapter is devoted to structure-activity relationships in this class of the aromatic compounds.

Animal Models of Molecular Pathology
Animal Models of Molecular Pathology

Author: P. Michael Conn

Publisher: Academic Press

Published: 2011-11-26

Total Pages: 479

ISBN-13: 0123948312

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This volume explores some of the most exciting recent advances in basic research on animal models of molecular pathology. - This series provides a forum for discussion of new discoveries, approaches, and ideas - Contributions from leading scholars and industry experts - Reference guide for researchers involved in molecular biology and related fields

Environmental Carcinogens
Environmental Carcinogens

Author: G. Grimmer

Publisher: CRC Press

Published: 2018-01-18

Total Pages: 272

ISBN-13: 1351080202

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The present survey comprises today‘s knowledge of environmental pollution in particular of the atmosphere by PAH and of the biological effects of this class of substance, putting special emphasis on their carcinogenic activity. The research data and conclusions derived therefrom are meant to assist the government of the Federal Republic of Germany in determining an air quality standard.

Chemical Carcinogenesis
Chemical Carcinogenesis

Author: Trevor M. Penning

Publisher: Springer Science & Business Media

Published: 2011-03-03

Total Pages: 447

ISBN-13: 1617379956

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This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

Smoking and Health
Smoking and Health

Author: United States. Surgeon General's Advisory Committee on Smoking and Health

Publisher:

Published: 1964

Total Pages: 406

ISBN-13:

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DNA Damage, DNA Repair and Disease
DNA Damage, DNA Repair and Disease

Author: Miral Dizdaroglu

Publisher: Royal Society of Chemistry

Published: 2020-11-11

Total Pages: 509

ISBN-13: 1839162562

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The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

Cancer Biology and Therapeutics
Cancer Biology and Therapeutics

Author: Joseph G. Cory

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 266

ISBN-13: 1475795645

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In anticipation of the opening of the H. Lee Moffitt Cancer Center and Research lnstitut~ on the campus of the University of South Florida, an international symposium, "The First Annual H. Lee Moffitt Symposium on Cancer Biology and Therapeutics" was held in Tampa, Florida on January 20-22, 1986. In this first symposium we decided to present a broad-based series of topics dealing with the major issues in the field of cancer. These topics ranged from the biochemistry of the cancer cell to the design of antineoplastic agents, through tumor cell heterogeneity, treatment of ltuman neoplasms to immunological aspects of cancer biology and tr~atment. The speakers chosen represented individuals of international acclaim who are very active in the area of cancer research and treatment. The symposium brought together scien tists/physicians from six nations including Austria, Canada, France, Hungary, West Germany, and of course, the United States. The congeniality of the participants promoted the friendly exchange of knowledge which, it is hoped, will greatly hasten the time when successful management of human cancer will become routine. Future symposia in this series will be highly focused and will deal with a single facet of this vast field of cancer research and treatment. Joseph G. Cory, Editor Andor Szentivanyi, Editor University of South Florida, 1986 V ACKNOWLEDGMENTS This volume presents the Proceedings of the H. Lee Moffitt International Syn~osium on Cancer Biology and Therapeutics which was held in Tampa, Florida on January 20, 21, and 22, 1986.

Carcinogenesis
Carcinogenesis

Author: William Montagna

Publisher: Elsevier

Published: 2017-03-31

Total Pages: 375

ISBN-13: 1483280292

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Advances in Biology of Skin, Volume VII: Carcinogenesis covers proceedings of the 15th Symposium on the Biology of Skin, held at the Oregon Regional Primate Research Center on April 9-11, 1965, under the auspices of the University of Oregon Medical School. This book is composed of nineteen chapters, and begins with the mechanism of tissue homeostasis in adult mammals and the kinetics of epidermal reaction to carcinogenic agents and other skin irritants. The succeeding chapters deal with the growth promoting effects of tumors on tissues, the reaction pattern distinctions between normal and neoplastic epithelium, and some biological implications of chemical carcinogenesis. Considerable chapters are devoted to various carcinogens, including hydrocarbons, viruses, androgens, and estrogens. Other chapters consider the physicochemical mechanisms of acceleration of skin carcinogenesis and experimental observations of environmental carcinogenesis. The mechanisms of skin cancer induction due to ultraviolet radiation, as well as arsenic induced tumors are examined. The concluding chapters describe some forms of skin tumors, such as adnexal tumors and basal cell epithelioma. This book will prove useful to oncologists and researchers in the field of carcinogenesis.