Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis
Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis

Author: George G. Harrigan

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 342

ISBN-13: 1461503337

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It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

Genetics Meets Metabolomics
Genetics Meets Metabolomics

Author: Karsten Suhre

Publisher: Springer Science & Business Media

Published: 2012-06-15

Total Pages: 328

ISBN-13: 1461416892

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This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.

Plant Metabolomics
Plant Metabolomics

Author: Kazuki Saito

Publisher: Springer Science & Business Media

Published: 2006-06-29

Total Pages: 351

ISBN-13: 3540297820

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Metabolomics – which deals with all metabolites of an organism – is a rapidly-emerging sector of post-genome research fields. It plays significant roles in a variety of fields from medicine to agriculture and holds a fundamental position in functional genomics studies and their application in plant biotechnology. This volume comprehensively covers plant metabolomics for the first time. The chapters offer cutting-edge information on analytical technology, bioinformatics and applications. They were all written by leading researchers who have been directly involved in plant metabolomics research throughout the world. Up-to-date information and future developments are described, thereby producing a volume which is a landmark of plant metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all plant science fields.

Data Analysis for Omic Sciences: Methods and Applications
Data Analysis for Omic Sciences: Methods and Applications

Author:

Publisher: Elsevier

Published: 2018-09-22

Total Pages: 732

ISBN-13: 0444640452

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Data Analysis for Omic Sciences: Methods and Applications, Volume 82, shows how these types of challenging datasets can be analyzed. Examples of applications in real environmental, clinical and food analysis cases help readers disseminate these approaches. Chapters of note include an Introduction to Data Analysis Relevance in the Omics Era, Omics Experimental Design and Data Acquisition, Microarrays Data, Analysis of High-Throughput RNA Sequencing Data, Analysis of High-Throughput DNA Bisulfite Sequencing Data, Data Quality Assessment in Untargeted LC-MS Metabolomic, Data Normalization and Scaling, Metabolomics Data Preprocessing, and more. - Presents the best reference book for omics data analysis - Provides a review of the latest trends in transcriptomics and metabolomics data analysis tools - Includes examples of applications in research fields, such as environmental, biomedical and food analysis

Metabolic Pathway Design
Metabolic Pathway Design

Author: Pablo Carbonell

Publisher: Springer Nature

Published: 2019-11-05

Total Pages: 170

ISBN-13: 3030298655

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This textbook presents solid tools for in silico engineering biology, offering students a step-by-step guide to mastering the smart design of metabolic pathways. The first part explains the Design-Build-Test-Learn-cycle engineering approach to biology, discussing the basic tools to model biological and chemistry-based systems. Using these basic tools, the second part focuses on various computational protocols for metabolic pathway design, from enzyme selection to pathway discovery and enumeration. In the context of industrial biotechnology, the final part helps readers understand the challenges of scaling up and optimisation. By working with the free programming language Scientific Python, this book provides easily accessible tools for studying and learning the principles of modern in silico metabolic pathway design. Intended for advanced undergraduates and master’s students in biotechnology, biomedical engineering, bioinformatics and systems biology students, the introductory sections make it also useful for beginners wanting to learn the basics of scientific coding and find real-world, hands-on examples.

Graphs, Networks and Algorithms
Graphs, Networks and Algorithms

Author: Dieter Jungnickel

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 597

ISBN-13: 3662038226

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Revised throughout Includes new chapters on the network simplex algorithm and a section on the five color theorem Recent developments are discussed

Metabolomics: From Fundamentals to Clinical Applications
Metabolomics: From Fundamentals to Clinical Applications

Author: Alessandra Sussulini

Publisher: Springer

Published: 2017-01-28

Total Pages: 353

ISBN-13: 3319476564

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This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

High-Throughput Metabolomics
High-Throughput Metabolomics

Author: Angelo D'Alessandro

Publisher: Humana

Published: 2020-06-06

Total Pages: 459

ISBN-13: 9781493992386

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This detailed volume focuses on recent technological, computational, and biostatistical advances in the field of high-throughput metabolomics. Chapters encompass methods, platforms, and analytical strategies for steady state measurements and metabolic flux analysis with stable isotope-labeled tracers, in biological matrices of clinical relevance and model organisms. Mass spectrometry-based or orthogonal methods are discussed, along with computational and statistical methods to address data sparsity in high-throughput metabolomics approaches. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High-Throughput Metabolomics: Methods and Protocols provides tools that can bring about the next generation of clinical biochemistry in a cost-effective, rigorous fashion, exponentially advancing our capacity to investigate nature while hastening the advent of personalized medicine.

Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology
Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology

Author: Kumar Selvarajoo

Publisher: Springer Nature

Published: 2022-10-13

Total Pages: 457

ISBN-13: 1071626175

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This volume provides protocols for computational, statistical, and machine learning methods that are mainly applied to the study of metabolic engineering, synthetic biology, and disease applications. These techniques support the latest progress in cross-disciplinary research that integrates the different scales of biological complexity. The topics covered in this book are geared toward researchers with a background in engineering, computational analytical, and modeling experience and cover a broad range of topics in computational and machine learning approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology is a valuable resource for any researcher or scientist who wants to learn more about the latest computational methods and how they are applied toward the understanding and prediction of complex biology.