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Author: Rogier Willem Sanders
Publisher: Amsterdam University Press
Published: 2003-12-01
Total Pages: 342
ISBN-13: 9789053566671
DOWNLOAD EBOOKThe need for a vaccine against HIV is obvious, but the development of an effective vaccine has met with frustrations. The HIV envelope glycoproteins, residing in the viral membrane, are the sole viral proteins exposed on the outside of virus particles and.
Author: Thomas J. Hope
Publisher:
Published:
Total Pages:
ISBN-13: 9781461496106
DOWNLOAD EBOOKAuthor: Derek T. O’Hagan
Publisher: Springer Science & Business Media
Published: 2008-02-02
Total Pages: 343
ISBN-13: 1592590837
DOWNLOAD EBOOKDerek T. O'Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, and suggests why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today's researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way.
Author: Sunil Thomas
Publisher:
Published: 2016
Total Pages: 873
ISBN-13: 9781493933877
DOWNLOAD EBOOKAuthor: P.K. Vogt
Publisher: Springer
Published: 2011-11-20
Total Pages: 0
ISBN-13: 9783642708121
DOWNLOAD EBOOKThe technique of microinjection along with viral genetics and molecular biology has proven useful in the correlation of retroviral polynucleotide structure with function. The advantage of this technique is the involvement of living cells where rare activities may be observed and where properties of living cells can be assayed. Future studies involving recombinant DNA molecules and the asso ciation of proteins with nucleic acids promise to yield additional insight into the nucleotide sequences involved in the expression of viral activities. References Anderson SM, Chen JH (1981) In vitro translation of avian myeloblastosis virus RNA. J Virol 40: 107-117 Berget SM, Moore C, Sharp PA (1977) Spliced segments of the 5' terminus of adenovirus 2 late mRNA. Proc Nat! Acad Sci USA 74:3171-3175 Bishop JM (1978) Retroviruses. Annu Rev Biochem 47:35-88 Capecchi MR (1980) High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell 22:479-488 Chien, Y-H, Junghans RP, Davidson W (1980) Electron microscopic analysis of the structure of RNA tumor virus nucleic acids. In: Stephenson JR (ed) Molecular biology of RNA tumor viruses.
Author: Paul Shapshak
Publisher: Springer
Published: 2017-10-07
Total Pages: 1059
ISBN-13: 1493972901
DOWNLOAD EBOOKThis book on NeuroAIDS, a collection of chapters written by experts and specialists from around the world, provides a global perspective on HIV and NeuroAIDS in the field, clinic, and laboratory. The chapters address the comorbidity of HIV and other infectious agents, including Zika virus, Ebola, Chagas disease, TB and HCV. Also discussed are key topics, such as: · Molecular socioepidemiology · Global HIV and NeuroAIDS · Neuropathology · cART and blood-brain barrier penetration · HIV replicative oscillations · HIV and SIV evolution · Psychiatric comorbidities · Neurosyphilis · The examination of current and innovative models of translational research to translational effectiveness
Author: Rino Rappuoli
Publisher: Caister Academic Press Limited
Published: 2011
Total Pages: 0
ISBN-13: 9781904455745
DOWNLOAD EBOOKIn this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies.
Author: Linqi Zhang
Publisher: Springer
Published: 2018-07-20
Total Pages: 326
ISBN-13: 981130484X
DOWNLOAD EBOOKThis book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.
Author: Howard E. Gendelman, MD
Publisher: Oxford University Press
Published: 2011-11-29
Total Pages: 1156
ISBN-13: 0199875553
DOWNLOAD EBOOKFrom basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
Author: Jennie R. Lill
Publisher: John Wiley & Sons
Published: 2017-08-14
Total Pages: 378
ISBN-13: 1119053102
DOWNLOAD EBOOKThe definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.
