Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering
Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering

Author: Dipankar Chattopadhyay

Publisher: Elsevier

Published: 2024-10-09

Total Pages: 513

ISBN-13: 0323958389

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Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering covers core elements of scaffold design, from properties and characterization of polymeric scaffolds to fabrication techniques and the structure-property relationship. Particular attention is given to the cell-scaffold interaction at the molecular level, helping the reader understand and adapt scaffold design to improve biocompatibility and function. The book goes on to discuss a range of tissue engineering applications for polymeric scaffolds, including bone, nerve, cardiac and fibroblast tissue engineering. Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering is an important, interdisciplinary work of relevance to materials scientists, polymer scientists, biomedical engineers and those working regenerative medicine. - Helps the reader determine the most appropriate polymer for scaffold design by characterization, properties and structure-property relationship - Discusses material-cell interactions at the molecular level, aiding in determining suitability - Covers core elements of scaffold design, including fabrication techniques

Characterization of Biomaterials
Characterization of Biomaterials

Author: Mangal Roy

Publisher: Elsevier Inc. Chapters

Published: 2013-03-12

Total Pages: 19

ISBN-13: 0128071036

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In joint replacement surgery with suboptimal bone, allograft materials are often used to achieve biological fixation of the metallic implant to the host bone and reducing the implant fixation time. The most commonly used techniques are cemented and hydroxyapatite (HA)-coated metallic implants. Typically, HA coatings are suggested for patients with better bone stock, whereas recommended implant fixation process for most other osteoporotic patients is bone cements. In general, there is a long-standing need to improve the performance of hip and other devices for longer in vivo implant lifetime that can help in reducing the number of revision surgeries, as well as minimizing physical and mental trauma to the patient. To achieve these goals, it is important to understand the mechanical and biological properties of coatings that can influence not only its short- and long-term bioactivity but also life span in vivo. Over the years, it has been recognized that the stability of a coated implant is governed by its physical and mechanical properties. A coating that separates from the implant provides no advantage over an uncoated implant and undesirable due to problems with debris materials, which can lead to osteolysis. Therefore, it is important to properly characterize the coated implants in terms of its physical and mechanical properties. In this chapter, specific details on coating characterization techniques including sample dimensions, sample preparation, experimental procedure and data interpretation are discussed. In particular, the standards and requirements of regulatory organizations are presented elucidating the significance and use of each characterization. It is important to appreciate that mechanical properties of coatings can only be determined with certain coating specification such as coating thickness. This chapter is designed even for non-experts to follow mechanical property characterizations of coatings on medical implants.

Biomimetic Polymers
Biomimetic Polymers

Author: C.G. Gebelein

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 297

ISBN-13: 1461306574

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The term biomimetic is comparatively new on the chemical scene, but the concept has been utilized by chemists for many years. Furthermore, the basic idea of making a synthetic material that can imitate the func tions of natural materials probably could be traced back into antiquity. From the dawn of creation, people have probably attempted to duplicate or modify the activities of the natural world. (One can even find allusions to these attempts in the Bible; e. g. , Genesis 30. ) The term "mimetic" means to imitate or mimic. The word "mimic" means to copy closely, or to imitate accurately. Biomimetic, which has not yet entered most dictionaries, means to imitate or mimic some specific bio logical function. Usually, the objective of biomimetics is to form some useful material without the need of utilizing living systems. In a simi lar manner, the term biomimetic polymers means creating synthetic poly mers which imitate the activity of natural bioactive polymers. This is a major advance in polymer chemistry because the natural bioactive polymers are the basis of life itself. Thus, biomimetic polymers imitate the life process in many ways. This present volume delineates some of the recent progress being made in this vast field of biomimetic polymers. Chemists have been making biomimetic polymers for more than fifty years, although this term wasn't used in the early investigations.

Bioinspired Structures and Design
Bioinspired Structures and Design

Author: Wole Soboyejo

Publisher: Cambridge University Press

Published: 2020-09-17

Total Pages: 374

ISBN-13: 1108963447

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Master simple to advanced biomaterials and structures with this essential text. Featuring topics ranging from bionanoengineered materials to bio-inspired structures for spacecraft and bio-inspired robots, and covering issues such as motility, sensing, control and morphology, this highly illustrated text walks the reader through key scientific and practical engineering principles, discussing properties, applications and design. Presenting case studies for the design of materials and structures at the nano, micro, meso and macro-scales, and written by some of the leading experts on the subject, this is the ideal introduction to this emerging field for students in engineering and science as well as researchers.

In Situ Tissue Regeneration
In Situ Tissue Regeneration

Author: Sang Jin Lee

Publisher: Academic Press

Published: 2016-07-17

Total Pages: 460

ISBN-13: 012802500X

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In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. - Explores the body's ability to mobilize endogenous stem cells to the site of injury - Details the latest strategies developed for inducing and supporting the body's own regenerating capacity - Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume - Features chapter authors and editors who are authorities in this emerging field - Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

Biomimetics -- Materials, Structures and Processes
Biomimetics -- Materials, Structures and Processes

Author: Petra Gruber

Publisher: Springer Science & Business Media

Published: 2011-07-06

Total Pages: 273

ISBN-13: 3642119344

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The book presents an outline of current activities in the field of biomimetics and integrates a variety of applications comprising biophysics, surface sciences, architecture and medicine. Biomimetics as innovation method is characterised by interdisciplinary information transfer from the life sciences to technical application fields aiming at increased performance, functionality and energy efficiency. The contributions of the book relate to the research areas: - Materials and structures in nanotechnology and biomaterials - Biomimetic approaches to develop new forms, construction principles and design methods in architecture - Information and dynamics in automation, neuroinformatics and biomechanics Readers will be informed about the latest research approaches and results in biomimetics with examples ranging from bionic nano-membranes to function-targeted design of tribological surfaces and the translation of natural auditory coding strategies.

Biomimetics
Biomimetics

Author: Bharat Bhushan

Publisher: Springer

Published: 2016-02-19

Total Pages: 607

ISBN-13: 3319282840

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This revised, updated and expanded new edition presents an overview of biomimetics and biologically inspired structured surfaces. It deals with various examples of biomimetics which include surfaces with roughness-induced superomniphobicity, self-cleaning, antifouling, and controlled adhesion. The focus in the book is on the Lotus Effect, Salvinia Effect, Rose Petal Effect, Oleophobic/philic Surfaces, Shark Skin Effect, and Gecko Adhesion. This new edition also contains new chapters on the butterfly wing effect, bio- and inorganic fouling and structure and Properties of Nacre and structural coloration.

Biomaterials Science
Biomaterials Science

Author: Buddy D. Ratner

Publisher: Elsevier

Published: 2004-08-18

Total Pages: 879

ISBN-13: 008047036X

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The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials. - Provides comprehensive coverage of principles and applications of all classes of biomaterials - Integrates concepts of biomaterials science and biological interactions with clinical science and societal issues including law, regulation, and ethics - Discusses successes and failures of biomaterials applications in clinical medicine and the future directions of the field - Cover the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites - Endorsed by the Society for Biomaterials