Gene Regulation, Epigenetics and Hormone Signaling
Gene Regulation, Epigenetics and Hormone Signaling

Author: Subhrangsu S. Mandal

Publisher: John Wiley & Sons

Published: 2017-10-23

Total Pages: 678

ISBN-13: 3527322817

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The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

Fundamentals of Epigenetics
Fundamentals of Epigenetics

Author: Gurbachan S. Miglani

Publisher: I K International Pvt Ltd

Published: 2023-05-23

Total Pages: 1048

ISBN-13: 939062097X

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Fundamentals of Epigenetics provides concise yet complete information on the many aspects of the basic and most recent concepts in epigenetics, a branch of life science that deals with the mechanisms such as DNA modifications, histone modifications, RNA modifications, small and long non-coding RNAs, chromatin remodeling, which are involved in epigenetic control of gene expression without involving variations in DNA sequences. These regulatory mechanisms lead to phenotypic variations. These epigenetic mechanisms can be exploited for crop improvement and cure of human diseases. This book is primarily designed for undergraduate and graduate level students studying epigenetics in conventional, agricultural and medicinal universities. Teachers and researchers in any discipline of life sciences, agricultural sciences, medicine, and biotechnology, molecular epigenetics and biotechnology will also find it useful as a reference book.

Histone Recognition
Histone Recognition

Author: Ming-Ming Zhou

Publisher: Springer

Published: 2015-05-29

Total Pages: 284

ISBN-13: 3319181025

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This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy
Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy

Author: Shabir Ahmad Ganai

Publisher: Springer Nature

Published: 2020-11-23

Total Pages: 266

ISBN-13: 9811581797

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This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. The book begins with an overview of various epigenetic modifying enzymes that are involved in cancer transition and progression; before exploring the potential of HDACs in cancer treatment. It provides a classification of HDAC inhibitors based on their structural attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it discusses and assesses the rationale behind therapies that combine HDAC inhibitors with other anticancer agents to treat solid tumors. Given its scope, it offers a valuable resource for all researchers, clinicians, and students working in formulation, drug discovery, oncology, and personalized medicine.