Cytokines and the Brain
Cytokines and the Brain

Author:

Publisher: Elsevier

Published: 2008-06-18

Total Pages: 609

ISBN-13: 0080559352

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This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer’s disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment. *Opens a new page of neuro-immunobiology and provides substantive evidence for the promise of this field in the treatment of disease*Summarizes current understanding on the presence and function of central nervous system (CNS) cytokines and their receptors in a variety of CNS cells during health and disease*Includes novel approaches to the treatment of CNS disorders based on new experimental data*Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment

Cytokines and the Cns
Cytokines and the Cns

Author: Richard M Ransohoff

Publisher: CRC Press

Published: 2019-08-30

Total Pages: 384

ISBN-13: 9780367391935

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Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines. The similarity between factors involved in inflammation or immunity, and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essential element in the neurobiologist's cognitive tool-kit. Conversely, for immunobiologists, the concepts elaborated by neurobiologists to understand developmental patterning and networked organ function continue to evolve in such a way that comprehension of cytokine action in the CNS can only enhance a further understanding of immune system function. Cytokines and the CNS, Second Edition is patterned after the first edition; however, the wealth of knowledge now available adds a tremendous amount of insight and new implications. To guarantee a fresh perspective, the editors made a conscious choice to utilize an entirely new set of contributors, all experts in various aspects of cytokine research. Cytokines and the CNS, Second Edition starts with a chapter on the CNS, focusing on pathological reactions to insult. Next, come three chapters on cytokine biology, followed by four chapters that integrate cytokine biology into basic CNS processes (development; inflammation; immunity; degeneration/repair), after which five chapters apply this body of knowledge to disease or pathology. The book closes with a look at the application of cytokine biology to the treatment of disease, a brand new area of research.

Brain Neurosecretory Cytokines
Brain Neurosecretory Cytokines

Author: Armen Galoyan

Publisher: Springer Science & Business Media

Published: 2004-04-30

Total Pages: 202

ISBN-13: 9780306483370

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Brain Neurosecretory Cytokines: Immune Response and Neuronal Survival summarizes the biological and chemical data of signal molecules of the brain neuroendocrine immune system, mainly proline-rich peptides, which play an important role in the regulation of immune response, neuronal survival, hematopoiesis, and adaptation. The author also describes the role of PRPs for the protection of neurons against neurodegenerative disturbances and diseases. Brain Neurosecretory Cytokines: Immune Response and Neuronal Survival will be of great aid to the researchers and students in various areas of neurobiological profile (neurochemistry, neuroendocrinology, neurophysiology, and endocrinology).

Cytokines and Pain
Cytokines and Pain

Author: L.R. Watkins

Publisher: Springer Science & Business Media

Published: 1999

Total Pages: 248

ISBN-13: 9783764358495

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The purpose of this book is to examine immune-to-brain communication from the viewpoint of its effect on pain processing, and to clarify the major role that substances released by immune cells play in pain modulation. In these chapters, contributed by major laboratories whose focus is understanding how cytokines modulate pain, the perspectives examined range from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. -- book cover.

Cytokines and Mental Health
Cytokines and Mental Health

Author: Ziad Kronfol

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 436

ISBN-13: 146150323X

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Cytokines and Mental Health explores the relationship between cytokines, neural circuitry and mental health. It is interdisciplinary and "translational", bringing together information that spans the spectrum from the molecular and cellular levels to the patient and the clinic. Content includes chapters that discuss cytokine pathways in the brain, the neurochemical and neuroendocrine effects of cytokines, and the behavioral effects of cytokines including sickness behavior. These chapters in basic research are followed by a more clinical section that discusses the role of cytokines in neuropsychiatric disorders such as major depression, schizophrenia and Alzheimer's disease. The book offers different things to different people. It should be of great interest to neuroscientists and immunologists working in the field of psychoneuroimmunology. It would also greatly benefit mental health professionals including psychiatrists, psychologists and clinicians of diverse background who are interested in mind-body medicine.

Interleukin-1 in the Brain
Interleukin-1 in the Brain

Author: Nancy J. Rothwell

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 216

ISBN-13: 1483287769

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Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.

Cytokines, Stress, and Depression
Cytokines, Stress, and Depression

Author: Robert Dantzer

Publisher: Taylor & Francis US

Published: 1999-07-31

Total Pages: 1

ISBN-13: 0306461358

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Until a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a synthesis between the exciting new developments in cytokine research and their implications for the pathophysiology of mental disorders.

The Neuroimmunological Basis of Behavior and Mental Disorders
The Neuroimmunological Basis of Behavior and Mental Disorders

Author: Allan Siegel

Publisher: Springer Science & Business Media

Published: 2008-11-09

Total Pages: 437

ISBN-13: 0387848517

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For many years, the immune and central nervous systems were thought to function independently with little or no interaction between the two. This view has und- gone dramatic changes over the past three decades. Indeed, we now know that there exists various feedback loops between the brain and immune systems that impact signi cantly upon different behavioral processes, including normal behavior and mental disorders. Pioneering efforts in generating this change were initiated by a number of early investigators. Included were those whose efforts were directed at establishing neuroimmune connections as well as others whose research focused upon the relationship between immunity, cytokines, and behavior. This book brings together outstanding scientists and clinicians who have made major contributions to the rapidly developing eld investigating the relationship between immunity and behavior. The book is divided into three parts. The rst part describes pathways by which the brain and immune systems communicate and int- act with each other. In the chapter “Cytokines and the Blood–Brain Barrier” p- vides insight into interactions between the blood–brain barrier and cytokines. Such interactions underlie basic communication between the immune system and brain that are present in normal as well as in disease conditions. In the chapter “Neu- chemical and Endocrine Responses to Immune Activation: The Role of Cytokines,” the neurochemical and endocrine consequences of immune challenge and cytokine administration on central neurotransmitter activity are discussed.