Information about histocompatibility antigens is expanding so rapidly that it is difficult to remain abreast of aB advances. In these volumes, we have made an effort to bring together the most current work on topics that have generated most of the re cent advances and discussions. We have asked each author to present and interpret his most current work, and we have judiciously refrained from imposing our own prejudices and viewpoints. Although there is obvious overlap in some individual topics, we have encouraged this to provide the reader with as many different and some times opposing viewpoints as possible. This approach will, we liope, give a broad overview of current ideas in the field. We wish to thank all contributors for their timely and exciting manu scripts, and we sincerely hope that the reader will benefit from these volumes. R. A. Reisfeld S. Ferrone La Jolla ix Contents I. Serology and Genetics Chapter 1 Studies of HLA-DR Antigens by Complement Fixation Jacques M. Colombani, Laurent Degos, Virginia Lepage, Helene Dastot, Muriel Reboul, and Pierre Lethielleux 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Material and Methods. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Results and Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3. 1. Screening for Anti-HLA-DR Complement-Fixing Sera . . . . . . . . 4 3. 2. Expression of HLA-A, -B and -DR Antigens on Peripheral Blood Lymphocytes during Phytohemagglutinin Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3. 3. Expression of HLA-A, -B and -DR Antigens on Peripheral Blood Lymphocytes during Concanavalin A Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 4.
This atlas describes and illustrates the pathology of solid organ transplants and includes chapters covering transplant pathology of the kidney, lung, heart, liver, pancreas, small bowel and limbs. Each of these chapters briefly reviews the latest rejection classifications for each organ system with explanatory notes highlighting diagnostic criteria, and tables listing entities in the differential diagnosis. Included with each chapter are images demonstrating the pathology of the most common and important diseases, especially patterns of organ rejection and related entities or mimickers. Examples of classic disease processes are provided, as well as atypical presentations that may highlight and prevent diagnostic pitfalls. A comprehensive explanation of the immunogenetics of transplant rejection is included, enabling the general pathologist to become familiar with the most important aspects of serologic testing in this patient population. A review of post-transplant lymphoproliferative diseases is also provided. Practical Atlas of Transplant Pathology is aimed at both general and expert pathologists who encounter transplant pathology specimens in their practice.
Books on both chicken immunology and developmental biology are rare. This one, however, summarizes all aspects of both areas and therefore represents a valuable compendium for experienced researchers as well as for all newcomers to the field. Following a lengthy discussion of the origin of hemopoietic cells, regulatory elements for the differentiation of these cells and B and T cell lymphopoiesis, the book goes on to describe the generation of transgenic chickens as well as an additional basic feature in embryogenesis: the positioning of organ anlage, e.g. the limb bud. To round off, a valuable compilation of monoclonal antibodies further enhances the practical usefulness of this important book.
