Current Status Of Neutron-scattering Research And Facilities In The United States
Current Status Of Neutron-scattering Research And Facilities In The United States

Author: National Research Council (U S ) Panel

Publisher: Legare Street Press

Published: 2023-07-18

Total Pages: 0

ISBN-13: 9781019734032

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This comprehensive report provides an overview of neutron-scattering research in the United States, including information on facilities, funding, and emerging areas of interest. Written by leading experts in the field, it is essential reading for anyone working in materials science, chemistry, or physics. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

An Assessment of the National Institute of Standards and Technology Center for Neutron Research
An Assessment of the National Institute of Standards and Technology Center for Neutron Research

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-01-31

Total Pages: 32

ISBN-13: 0309389119

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At the request of the National Institute of Standards and Technology (NIST), the National Academies of Sciences, Engineering, and Medicine has, since 1959 annually assembled panels of experts from academia, industry, medicine, and other scientific and engineering environments to assess the quality and effectiveness of the NIST measurements and standards laboratories, of which there are now seven, as well as the adequacy of the laboratories' resources. An Assessment of the National Institute of Standards and Technology Center for Neutron Research: Fiscal Year 2015 reviews the organization's technical programs, the portfolio of scientific expertise within the organization, the adequacy of the organization's facilities, equipment, and human resources, and the effectiveness with which the organization disseminates its program outputs.

High Magnetic Field Science and Its Application in the United States
High Magnetic Field Science and Its Application in the United States

Author: National Research Council

Publisher: National Academies Press

Published: 2013-12-25

Total Pages: 233

ISBN-13: 0309286344

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The Committee to Assess the Current Status and Future Direction of High Magnetic Field Science in the United States was convened by the National Research Council in response to a request by the National Science Foundation. This report answers three questions: (1) What is the current state of high-field magnet science, engineering, and technology in the United States, and are there any conspicuous needs to be addressed? (2) What are the current science drivers and which scientific opportunities and challenges can be anticipated over the next ten years? (3) What are the principal existing and planned high magnetic field facilities outside of the United States, what roles have U.S. high field magnet development efforts played in developing those facilities, and what potentials exist for further international collaboration in this area? A magnetic field is produced by an electrical current in a metal coil. This current exerts an expansive force on the coil, and a magnetic field is "high" if it challenges the strength and current-carrying capacity of the materials that create the field. Although lower magnetic fields can be achieved using commercially available magnets, research in the highest achievable fields has been, and will continue to be, most often performed in large research centers that possess the materials and systems know-how for forefront research. Only a few high field centers exist around the world; in the United States, the principal center is the National High Magnetic Field Laboratory (NHMFL). High Magnetic Field Science and Its Application in the United States considers continued support for a centralized high-field facility such as NHFML to be the highest priority. This report contains a recommendation for the funding and siting of several new high field nuclear magnetic resonance magnets at user facilities in different regions of the United States. Continued advancement in high-magnetic field science requires substantial investments in magnets with enhanced capabilities. High Magnetic Field Science and Its Application in the United States contains recommendations for the further development of all-superconducting, hybrid, and higher field pulsed magnets that meet ambitious but achievable goals.

Structural Biology in Drug Discovery
Structural Biology in Drug Discovery

Author: Jean-Paul Renaud

Publisher: John Wiley & Sons

Published: 2020-01-27

Total Pages: 692

ISBN-13: 1118900405

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With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins