Crystallographic Investigations of Respiratory Proteins
Author: Tina Michelle Iverson
Publisher:
Published: 2000
Total Pages: 582
ISBN-13:
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Author: Tina Michelle Iverson
Publisher:
Published: 2000
Total Pages: 582
ISBN-13:
DOWNLOAD EBOOKAuthor: Isabel Moraes
Publisher: Springer
Published: 2016-08-23
Total Pages: 188
ISBN-13: 3319350722
DOWNLOAD EBOOKThis book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. Chapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.
Author: Anthony Michael Glazer
Publisher: Oxford University Press
Published: 2016
Total Pages: 169
ISBN-13: 0198717598
DOWNLOAD EBOOKA long history -- Symmetry -- Crystal structures -- Diffraction -- Seeing atoms -- Sources of radiation
Author: National Institutes of Health (U.S.). Division of Research Grants
Publisher:
Published: 1975
Total Pages: 1224
ISBN-13:
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Publisher:
Published: 1992
Total Pages: 1064
ISBN-13:
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Publisher:
Published: 1991
Total Pages: 1104
ISBN-13:
DOWNLOAD EBOOKAuthor: Max F Perutz
Publisher: World Scientific
Published: 1998-01-15
Total Pages: 659
ISBN-13: 9814498513
DOWNLOAD EBOOKLinus Pauling called haemoglobin the most interesting and important of molecules. This important volume shows how X-ray crystallography was used to determine its bewilderingly complex atomic structure and to unravel the stereochemical mechanisms of its respiratory functions. It introduces isomorphous replacement with heavy atoms which led to the first protein structures, haemoglobin and its simpler relative myoglobin. Later papers deal with the stereochemistry of the cooperative effects of haemoglobin, with the relationships between the structures and impaired functions of abnormal haemoglobin, with species adaptation of haemoglobin, and with its action as a drug receptor and as an oxygen sensor. The final papers deal with amino acid repeats which act as polar zippers and their role in certain inherited neurodegenerative diseases.
Author: Bruce Alberts
Publisher:
Published: 2002
Total Pages: 0
ISBN-13: 9780815332183
DOWNLOAD EBOOKAuthor: Robert E. Babine
Publisher: John Wiley & Sons
Published: 2004-02-13
Total Pages: 284
ISBN-13: 9783527306787
DOWNLOAD EBOOKThe rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.