Coupling and Decoupling of Diverse Molecular Units in Glycosciences
Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Author: Zbigniew J. Witczak

Publisher: Springer

Published: 2017-11-20

Total Pages: 340

ISBN-13: 3319655876

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This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry. Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book.

Carbohydrate-Based Vaccines
Carbohydrate-Based Vaccines

Author: A. Krishna Prasad

Publisher: ACS Symposium

Published: 2019-09-23

Total Pages: 0

ISBN-13: 9780841233379

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The past three decades have witnessed the development and regulatory approval of glycoconjugate vaccines against several medically important bacterial pathogens, including Haemophilus influenzae type b, Streptococcus pneumoniae, Neisseria meningitides, and Salmonella typhi. Immunologic protection against these and many other bacterial diseases is mediated through opsonophagocytic antibodies directed against the surface carbohydrates that define the bacterial serogroup or serotype and serve as virulence factors. These vaccines are composed of bacterial capsular polysaccharides chemically conjugated to immunogenic carrier proteins. Given that the diseases caused by these bacterial pathogens are most pronounced in infants and young children, the development of the glycoconjugate vaccine technology has had a considerable impact on public health. Many of the chapters in this volume were assembled as a follow-up from a symposium entitled "Carbohydrate-Based Vaccines and Adjuvants" which took place at the 254th American Chemical Society National Meeting held in Washington, DC (August 2017). The symposium was sponsored by Pfizer and the Carbohydrate (CARB) and Biotechnology (BIOT) divisions. This book, therefore, reflects the importance of this field toward design, development, manufacture and licensure of the complex carbohydrate-based (glycoconjugate) vaccines. The book has been organized into thirteen chapters, which cover a comprehensive landscape including the clinical history, design, development, chemistry, manufacturing and control (CMC) aspects, pre-clinical assays, adjuvants and the various approaches used to develop carbohydrate-based vaccines.

Industrial Pharmaceutical Biotechnology
Industrial Pharmaceutical Biotechnology

Author: Heinrich Klefenz

Publisher: Wiley-VCH

Published: 2002-04-22

Total Pages: 328

ISBN-13:

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This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.

Analysis of Protein Post-Translational Modifications by Mass Spectrometry
Analysis of Protein Post-Translational Modifications by Mass Spectrometry

Author: John R. Griffiths

Publisher: John Wiley & Sons

Published: 2016-11-07

Total Pages: 414

ISBN-13: 1119045851

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Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research

The Art of Carbohydrate Analysis
The Art of Carbohydrate Analysis

Author: Gerrit J. Gerwig

Publisher: Springer Nature

Published: 2021-10-23

Total Pages: 362

ISBN-13: 303077791X

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The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.

Transforming Glycoscience
Transforming Glycoscience

Author: National Research Council

Publisher: National Academies Press

Published: 2012-10-23

Total Pages: 171

ISBN-13: 0309260868

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A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.

Organofluorine Compounds in Biology and Medicine
Organofluorine Compounds in Biology and Medicine

Author: V Prakash Reddy

Publisher: Newnes

Published: 2015-01-25

Total Pages: 331

ISBN-13: 044453749X

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Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area. - Covers the synthesis, biochemical, and therapeutic applications of organofluorine compounds - Offers a complete text on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways - Provides one of the first major reference books on the biological and medicinal applications of organofluorine chemistry

Basic 1H- and 13C-NMR Spectroscopy
Basic 1H- and 13C-NMR Spectroscopy

Author: Metin Balci

Publisher: Elsevier

Published: 2005-01-19

Total Pages: 441

ISBN-13: 0080525539

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Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful and theoretically complex analytical tool. Basic 1H- and 13C-NMR Spectroscopy provides an introduction to the principles and applications of NMR spectroscopy. Whilst looking at the problems students encounter when using NMR spectroscopy, the author avoids the complicated mathematics that are applied within the field. Providing a rational description of the NMR phenomenon, this book is easy to read and is suitable for the undergraduate and graduate student in chemistry. - Describes the fundamental principles of the pulse NMR experiment and 2D NMR spectra - Easy to read and written with the undergraduate and graduate chemistry student in mind - Provides a rational description of NMR spectroscopy without complicated mathematics

Electrochemistry of Nucleic Acids and Proteins
Electrochemistry of Nucleic Acids and Proteins

Author: E. Palecek

Publisher: Elsevier

Published: 2005-12-19

Total Pages: 809

ISBN-13: 0080457452

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DNA (sometimes referred to as the molecule of life), is the most interesting and most important of all molecules. Electrochemistry of Nucleic Acids and Proteins: Towards Electrochemical Sensors for Genomics and Proteomics is devoted to the electrochemistry of DNA and RNA and to the development of sensors for detecting DNA damage and DNA hybridization. Volume 1, in the brand new series Perspectives in Bioanalysis, looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century.* Covers highly sophisticated methods of electrochemical analysis of nucleic acids and proteins* Summarises the present state of electrochemical analysis of nucleic acids and proteins* Includes future trends in the electrochemical analysis in genomics and proteomics