"Contemporary Research in Bioinformatics" is a comprehensive exploration of the dynamic field that lies at the intersection of biology, data science, and computation. This book serves as a roadmap for readers to navigate the evolving landscapes of genomics, transcriptomics, proteomics, structural biology, machine learning, and more. In an age where the deluge of biological data presents both opportunities and challenges, bioinformatics emerges as the guiding light that empowers us to decipher the complexities of life. This book is designed to cater to a diverse audience, including researchers, students, educators, and professionals seeking to gain a deeper understanding of bioinformatics and its pivotal role in shaping modern biology and healthcare.
Biological and biomedical sciences are becoming more interdisciplinary, and scientists of the future need inte rdisciplinary training instead of the conventional disciplinary training. Just as Sean Eddy (2005) wiselypointed out that sending monolingual diplomats to the United Nations maynot enhance international collaborations, combining strictly disciplinary scientists trained in either mathematics, computational science or molecular biology will not create a productive inte rdisciplinary team ready to solve interdisciplinary problems. Molecular biology is an interdiscip linary science back in its heyday, and founders of molecular biology were ofte n interdisciplinary scientists. Indeed, Francis Crick considered himself as “a mixture of crystallographer, biophysicist, biochemist, and geneticist” (Crick, 1965). Because it was too cumbersome to explain to people that he was such a mixture, the term “molecular biologist” came handy. To get the crystallographer, biophysicist, biochemist, and geneticist within hi mself to collaborate with each other probably worked better than a team with a crystallographer, a biophysicist, a biochemist and a geneticist who maynot even be interested in each other’s problems.
This book introduces some key problems in bioinformatics, discusses the models used to formally describe these problems, and analyzes the algorithmic approaches used to solve them. After introducing the basics of molecular biology and algorithmics, Part I explains string algorithms and alignments; Part II details the field of physical mapping and DNA sequencing; and Part III examines the application of algorithmics to the analysis of biological data. Exciting application examples include predicting the spatial structure of proteins, and computing haplotypes from genotype data. Figures, chapter summaries, detailed derivations, and examples, are provided.
"In this book, Andy Baxevanis and Francis Ouellette . . . haveundertaken the difficult task of organizing the knowledge in thisfield in a logical progression and presenting it in a digestibleform. And they have done an excellent job. This fine text will makea major impact on biological research and, in turn, on progress inbiomedicine. We are all in their debt." —Eric Lander from the Foreword Reviews from the First Edition "...provides a broad overview of the basic tools for sequenceanalysis ... For biologists approaching this subject for the firsttime, it will be a very useful handbook to keep on the shelf afterthe first reading, close to the computer." —Nature Structural Biology "...should be in the personal library of any biologist who usesthe Internet for the analysis of DNA and protein sequencedata." —Science "...a wonderful primer designed to navigate the novice throughthe intricacies of in scripto analysis ... The accomplished genesearcher will also find this book a useful addition to theirlibrary ... an excellent reference to the principles ofbioinformatics." —Trends in Biochemical Sciences This new edition of the highly successful Bioinformatics:A Practical Guide to the Analysis of Genes and Proteinsprovides a sound foundation of basic concepts, with practicaldiscussions and comparisons of both computational tools anddatabases relevant to biological research. Equipping biologists with the modern tools necessary to solvepractical problems in sequence data analysis, the Second Editioncovers the broad spectrum of topics in bioinformatics, ranging fromInternet concepts to predictive algorithms used on sequence,structure, and expression data. With chapters written by experts inthe field, this up-to-date reference thoroughly covers vitalconcepts and is appropriate for both the novice and the experiencedpractitioner. Written in clear, simple language, the book isaccessible to users without an advanced mathematical or computerscience background. This new edition includes: All new end-of-chapter Web resources, bibliographies, andproblem sets Accompanying Web site containing the answers to the problems,as well as links to relevant Web resources New coverage of comparative genomics, large-scale genomeanalysis, sequence assembly, and expressed sequence tags A glossary of commonly used terms in bioinformatics andgenomics Bioinformatics: A Practical Guide to the Analysis of Genesand Proteins, Second Edition is essential reading forresearchers, instructors, and students of all levels in molecularbiology and bioinformatics, as well as for investigators involvedin genomics, positional cloning, clinical research, andcomputational biology.
In the current era of complete genome sequencing, Bioinformatics and Molecular Evolution provides an up-to-date and comprehensive introduction to bioinformatics in the context of evolutionary biology. This accessible text: provides a thorough examination of sequence analysis, biological databases, pattern recognition, and applications to genomics, microarrays, and proteomics emphasizes the theoretical and statistical methods used in bioinformatics programs in a way that is accessible to biological science students places bioinformatics in the context of evolutionary biology, including population genetics, molecular evolution, molecular phylogenetics, and their applications features end-of-chapter problems and self-tests to help students synthesize the materials and apply their understanding is accompanied by a dedicated website - www.blackwellpublishing.com/higgs - containing downloadable sequences, links to web resources, answers to self-test questions, and all artwork in downloadable format (artwork also available to instructors on CD-ROM). This important textbook will equip readers with a thorough understanding of the quantitative methods used in the analysis of molecular evolution, and will be essential reading for advanced undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics courses.
Advances in Biological Science Research: A Practical Approach provides discussions on diverse research topics and methods in the biological sciences in a single platform. This book provides the latest technologies, advanced methods, and untapped research areas involved in diverse fields of biological science research such as bioinformatics, proteomics, microbiology, medicinal chemistry, and marine science. Each chapter is written by renowned researchers in their respective fields of biosciences and includes future advancements in life science research. - Discusses various research topics and methods in the biological sciences in a single platform - Comprises the latest updates in advanced research techniques, protocols, and methods in biological sciences - Incorporates the fundamentals, advanced instruments, and applications of life science experiments - Offers troubleshooting for many common problems faced while performing research experiments
"This book covers research topics of data mining on bioinformatics presenting the basics and problems of bioinformatics and applications of data mining technologies pertaining to the field"--Provided by publisher.
Editor Biography:Dr. Rajeshwar P. Sinha is a Professor of Molecular Biology at the Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi, India. He received his Ph. D. in Biotechnology form Banaras Hindu University, Varanasi, India. He is a fellow of the Society for Applied Biotechnology, India and recipient of the prestigious DAAD (Germany) fellowship. He has visited several countries such as Argentina, Austria, Belgium, Canada, China, Germany, Greece, France, Italy, Japan, Luxembourg, Norway, Poland, Republic of Korea, Spain, Switzerland, The Netherlands and United Kingdom, in the field of academics and research on one or the other scientific assignments. He has over 23 years of research and teaching experience. He has been working on effects of UV radiation on aquatic ecosystems and has concentrated on the effects on DNA damage and repair, phycobilliproteins, mycosporine-like amino acids and scytonemin induction in cyanobacteria and algae. He is a life member of various national and international scientific societies and an editorial board member of several national and international scientific journals. He has published over 200 original research papers, reviews and book chapters and edited three books. He is having an h-index of 41 with over 6300 citations in reputed scientific journals including Nature and Science.Book Description:Biological science primarily deals with the morphology, physiology and biochemistry of living organisms, including their distribution, taxonomy, evolution, structure, growth, function and metabolism. All living organisms undergo metabolism, maintain homeostasis, have the capacity to grow, respond to stimuli, communicate through various means, reproduce and adapt to their environment through natural selection. The organisms that photosynthesize are the primary producers and represent life support systems from aesthetics to food to medicine. The book deals with the topics pertaining to biotechnology, molecular biology, ecology, plant pathology, bionanotechnology and stress biology. Technology-assisted research had led to the evolution of new disciplines of biological sciences with narrow specialization.The requirement of food, medicines, natural products, the quest to resolve and develop a better understanding of life and other biological processes need to conserve genes, plants and ecosystems; the apprehension of land, water and the environment have led to the strengthening of traditional disciplines as well as the emergence of diverse disciplines such as stress biology, molecular biology, biotechnology and bioinformatics.The chapters in this book impart the recent developments and the state-of-the art knowledge in biological sciences. In addition, this book provides newer techniques and uses for these tools in achieving the potential of biotechnology to understand some of the basic problems in biological sciences.Target Audience:This book is highly useful and must read for students, researchers and professionals in botany, biotechnology, environmental sciences, agriculture, molecular biology and other streams of biological sciences.
This report addresses a topic of recognized policy concern. To capture the benefits of substantial U.S. investments in biomedical R&D, parallel investments in a wide range of seemingly unrelated disciplines are also required. This report summarizes a major conference that reviewed our nation's R&D support for biotechnology and information technologies. The volume includes newly commissioned research and makes recommendations and findings concerning the important relationship between information technologies and biotechnology. It emphasizes the fall off in R&D investments needed to sustain the growth of the U.S. economy and to capitalize on the growing investment in biomedicine. It also encourages greater support for inter-disciplinary training to support new areas such as bioinformatics and urges more emphasis on and support for multi-disciplinary research centers.
