Peptide Macrocycles

Peptide Macrocycles

Author: Matthew B. Coppock

Publisher: Humana

Published: 2021-11-02

Total Pages: 469

ISBN-13: 9781071616888

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This volume explores the latest techniques and strategies used to study the field of peptide macrocycles. The chapters in this book ae organized into four parts: macrocycles synthesis, combinational library synthesis and screening, macrocycle characterization, and unique applications. Part One looks at a variety of peptide cyclization methodologies, and Part Two describes methods for the creation of peptide macrocycles libraries and their subsequent screening against biological targets of interest. Part Three discusses the study and characterization of peptide macrocycle-target interactions, and Part Four introduces unique applications for peptide macrocycles, from higher-order structure formation to post-synthetic functional modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Macrocycles: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this developing field.


The Modernisation of State Aid for Economic and Social Development

The Modernisation of State Aid for Economic and Social Development

Author: Bruno Nascimbene

Publisher: Springer

Published: 2018-11-28

Total Pages: 315

ISBN-13: 3319992260

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This book analyses the recent modernisation of EU State aid law from various perspectives, and considers both substantive and procedural aspects. It also discusses the reasons for, and the goals and future implications of the modernisation programme, including the evolution of the concept of State aid. The ambitious reform programme was launched in 2012 and has now been almost fully implemented by virtue of the adoption of new rules of procedure in July 2013, and exemption in June 2014. The book highlights the main aspects of this sector reform, which include the Commission’s change of attitude towards so-called positive aid, i.e. those able to promote economic growth, and the intention to focus on matters of greater systematic extent. These objectives also imply a third aspect: increasing the intensity of the control powers conferred on the Commission with regard to that aid that prove to be harmful to competition and the internal market. The book also examines the greater responsibility given to States for self-assessment of their economic policy measures, and explores the resulting impact on, and challenges posed to the administrations of the Member States. The book’s second part is devoted to the application State aid rules in the area of services of general economic interest, with a special focus on aid in the field of social health and infrastructure.


Rapid Prototyping & Manufacturing

Rapid Prototyping & Manufacturing

Author: Paul Francis Jacobs

Publisher: Society of Manufacturing Engineers

Published: 1992

Total Pages: 449

ISBN-13: 0872634256

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This turnkey technology source provides an introduction to rapid prototyping and manufacturing (RP&M) with emphasis on Stereolithography which represents the majority of all rapid prototyping systems currently in place. The content is based on theory, analysis and experiment with extensive test data, including select case studies from the automotive, simultaneous engineering, and medical sectors.


The Erasers

The Erasers

Author: Alain Robbe-Grillet

Publisher: Grove/Atlantic, Inc.

Published: 2015-06-23

Total Pages: 231

ISBN-13: 0802190553

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The first book from the French avant-gardist and author of Jealousy. “Robbe-Grillet is the forerunner of a revolution in the novel” (Claude Mauriac, cultural critic for Le Figaro). Alain Robbe-Grillet is internationally hailed as the chief spokesman for the nouveau roman and one of the great novelists of the twentieth century. The Erasers, his first novel, reads like a detective story but is primarily concerned with weaving and then probing a complete mixture of fact and fantasy. The narrative spans the twenty-four-hour period following a series of eight murders in eight days, presumably the work of a terrorist group. After the ninth murder, the investigation is turned over to a police agent—who may in fact be the assassin. Both an engrossing mystery and a sinister deconstruction of reality, The Erasers intrigues and unnerves with equal force as it pulls us along to its ominous conclusion. “On the surface, and surface is the key word with this author, The Erasers is a mystery story, where a police agent named Wallas stalks an unknown assassin through a nameless puzzleboard Flemish town . . . Nothing is certain. The only thing the reader can be sure of is the laser precise detail in which all that isn’t clear is described, catalogued and analyzed.” —The Millions “A haunting, mystifying evocation of a murder that will keep your attention riveted.” —The Dallas Morning News Praise for Alain Robbe-Grillet “I can think of no other writer who can render the banal so fearfully fantastic.” —Books and Bookmen “I doubt that fiction as art can any longer be seriously discussed without Robbe-Grillet.” —The New York Times


A Frequency Dictionary of Japanese

A Frequency Dictionary of Japanese

Author: Yukio Tono

Publisher: Routledge

Published: 2013-12-19

Total Pages: 813

ISBN-13: 1317831403

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A Frequency Dictionary of Japanese is an invaluable tool for all learners of Japanese, providing a list of the 5,000 most commonly used words in the language. Based on a100 million word corpus, composed of spoken, fiction, non-fiction and news texts in current use, the dictionary provides the user with a detailed frequency-based list, as well as alphabetical and part-of-speech indices. All entries in the frequency list feature the English equivalent and a sample sentence with English translation. The dictionary also contains 25 thematically organised lists of frequently used words on a variety of topics such as food, weather, occupations and leisure. Numerous bar charts are also included to highlight the phonetic and spelling variants across register. A Frequency Dictionary of Japanese enables students of all levels to maximise their study of Japanese vocabulary in an efficient and engaging way. It is also an excellent resource for teachers of the language.


Dunbar's Cove

Dunbar's Cove

Author: Borden Deal

Publisher:

Published: 1957

Total Pages: 456

ISBN-13:

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One man's fight to hold his land against the encroaching TVA.


Main Street U S S R

Main Street U S S R

Author: Irving R Levine

Publisher: Palala Press

Published: 2015-09-06

Total Pages: 420

ISBN-13: 9781341725548

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This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.