Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity

Author: Alexey Moskalev

Publisher: Academic Press

Published: 2017-11-17

Total Pages: 546

ISBN-13: 012811083X

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Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. - Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease - Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory - Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan


Being an Independent Regulator

Being an Independent Regulator

Author: OECD

Publisher: Org. for Economic Cooperation & Development

Published: 2016

Total Pages: 0

ISBN-13: 9789264255395

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This report identifies the critical points where undue influence can be exercised at different moments in the life of a regulator and discusses some of the avenues for developing a culture of independence, including through interactions with stakeholders, staffing and financing.


The Evolution of Social Behavior in Insects and Arachnids

The Evolution of Social Behavior in Insects and Arachnids

Author: Jae C. Choe

Publisher: Cambridge University Press

Published: 1997

Total Pages: 556

ISBN-13: 9780521589772

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'Social' insects and arachnids exhibit complex forms of behavior that involve cooperation in building a nest, defending against attackers or rearing offspring. This book is a comprehensive, up-to-date guide to sociality and its evolution in a wide range of taxa.


Principles of Animal Locomotion

Principles of Animal Locomotion

Author: R. McNeill Alexander

Publisher: Princeton University Press

Published: 2006-03-19

Total Pages: 384

ISBN-13: 0691126348

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How can geckoes walk on the ceiling and basilisk lizards run over water? What are the aerodynamic effects that enable small insects to fly? What are the relative merits of squids' jet-propelled swimming and fishes' tail-powered swimming? Why do horses change gait as they increase speed? What determines our own vertical leap? Recent technical advances have greatly increased researchers' ability to answer these questions with certainty and in detail. This text provides an up-to-date overview of how animals run, walk, jump, crawl, swim, soar, hover, and fly. Excluding only the tiny creatures that use cilia, it covers all animals that power their movements with muscle--from roundworms to whales, clams to elephants, and gnats to albatrosses. The introduction sets out the general rules governing all modes of animal locomotion and considers the performance criteria--such as speed, endurance, and economy--that have shaped their selection. It introduces energetics and optimality as basic principles. The text then tackles each of the major modes by which animals move on land, in water, and through air. It explains the mechanisms involved and the physical and biological forces shaping those mechanisms, paying particular attention to energy costs. Focusing on general principles but extensively discussing a wide variety of individual cases, this is a superb synthesis of current knowledge about animal locomotion. It will be enormously useful to advanced undergraduates, graduate students, and a range of professional biologists, physicists, and engineers.


Sexual Conflict

Sexual Conflict

Author: Göran Arnqvist

Publisher: Princeton University Press

Published: 2005-07-25

Total Pages: 356

ISBN-13: 9780691122182

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"This book demonstrates that , despite a shared genome, conflicts between interacting males and females are ubiquitous, and that selection in the two sexes is continuously pulling this genome in opposite directions." --Cover.


The Evolution of Mating Systems in Insects and Arachnids

The Evolution of Mating Systems in Insects and Arachnids

Author: Jae C. Choe

Publisher: Cambridge University Press

Published: 1997-06-12

Total Pages: 401

ISBN-13: 0521580293

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Insects and arachnids display the most impressive diversity of mating and social behaviour among all animals. This book investigates sexual competition in these groups, and the variety of ways in which males and females pursue, persuade, manipulate, control and help one another, enabling us to gain a better understanding of how conflicts and confluences of interest evolve together. Each chapter provides a comprehensive review of mating systems in particular insect and arachnid groups, discusses intrinsic and extrinsic factors responsible for observed mating strategies, and suggests fruitful avenues for further research. The book culminates in a synthesis, reviewing the date in terms of the theory of sexual conflict. This broad-based book will be of immense value to students and researchers interested in reproductive strategies, behavioural ecology, entomology and arachnology.


Market and Competition Authorities

Market and Competition Authorities

Author: Annetje Ottow

Publisher:

Published: 2015

Total Pages: 305

ISBN-13: 0198733046

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Market and competition authorities operate in a complex environment with conflicting stakeholder demands. Balancing the various interests of the authority and stakeholder in an objective and impartial manner is strategic to achieving the goals of the legislation imposed. In a fresh approach examining the actions of an authority when a regulation is applied, Annetje Ottow argues the vital importance of the behavior of authorities, focusing on five fundamental good agency principles: legality, independence, transparency, effectiveness, and responsibility, or, LITER. These principles provide agencies and those reviewing their actions with a framework for agency design and action. Combining theory and practice to provide insight into agencies' organization and behavior, this book outlines and analyses behavioral issues using an ecosystemic method, addressing how independent agencies should be assessed, and which principles should apply. Using cases from the Netherlands and the UK, Ottow examines the key processes of authorities against the LITER principles, and opens the debate on 'how to regulate the agency'.


The Making of Economic Policy

The Making of Economic Policy

Author: Avinash K. Dixit

Publisher: MIT Press

Published: 1998-09-01

Total Pages: 220

ISBN-13: 9780262540988

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The Making of Economic Policy begins by observing that most countries' trade policies are so blatantly contrary to all the prescriptions of the economist that there is no way to understand this discrepancy except by delving into the politics. The same is true for many other dimensions of economic policy. Avinash Dixit looks for an improved understanding of the politics of economic policy-making from a transaction cost perspective. Such costs of planning, implementing, and monitoring an exchange have proved critical to explaining many phenomena in industrial organization. Dixit discusses the variety of similar transaction costs encountered in the political process of making economic policy and how these costs affect the operation of different institutions and policies. Dixit organizes a burgeoning body of research in political economy in this framework. He uses U.S. fiscal policy and the General Agreement on Tariffs and Trade (GATT) as two examples that illustrate the framework, and show how policy often deviates from the economist's ideal of efficiency. The approach reveals, however, that some seemingly inefficient practices are quite creditable attempts to cope with transaction costs such as opportunism and asymmetric information. Copublished with the Center for Economic Studies and the Ifo Institute


Regulation in Practice

Regulation in Practice

Author: Martino Maggetti

Publisher:

Published: 2012

Total Pages: 0

ISBN-13: 9781907301285

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This book develops and applies an inventive theoretical approach, which combines different levels of analysis and activates a wide range of methods, to the comparative study of an important point that had been neglected so far, namely the real (or "de facto") independence of regulatory agencies. The first part of the book examines the organizational and institutional factors shaping de facto independence of regulatory agencies in Western Europe. Second, the role of independent regulatory agencies in the policy-making process is investigated, using de facto independence as an explanatory variable. The third part is devoted to the relations between regulatory agencies and the news media. In the conclusive discussion, the author also tackles a set of normative questions, which relates to the virtues and perils of independence.