Cytotoxic Payloads for Antibody–Drug Conjugates
Cytotoxic Payloads for Antibody–Drug Conjugates

Author: David E Thurston

Publisher: Royal Society of Chemistry

Published: 2019-07-11

Total Pages: 502

ISBN-13: 1788018451

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Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

Surface Modification of Nanoparticles for Targeted Drug Delivery
Surface Modification of Nanoparticles for Targeted Drug Delivery

Author: Yashwant V Pathak

Publisher: Springer

Published: 2019-03-11

Total Pages: 503

ISBN-13: 3030061159

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This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.

Competition, Innovation, and Growth in Japan
Competition, Innovation, and Growth in Japan

Author: Yuji Honjo

Publisher: Springer

Published: 2017-05-11

Total Pages: 269

ISBN-13: 9811038635

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This book addresses three important concepts in the economy—competition, innovation, and growth—using various cases and available data in Japan and other countries. First, the authors discuss competition, including global competition, to provide a better understanding of competition policy in Japan. Then, the authors examine the effects of human capital and alliance on innovation while providing new innovation indicators. Moreover, the authors examine growth from the perspective of corporate strategy such as acquisition, including international comparison. The interplay of competition, innovation, and growth has been prevalent in Japan, and it still acts as a catalyst for stimulating the stagnant economy. A better understanding of competition, innovation, and growth provides the tools to reinvigorate the stagnant economy in Japan and to reinforce the economy in other countries where the period of rapid growth has ended.

Soil Microbiology and Sustainable Crop Production
Soil Microbiology and Sustainable Crop Production

Author: Geoffrey R. Dixon

Publisher: Springer Science & Business Media

Published: 2010-09-08

Total Pages: 444

ISBN-13: 9048194792

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Soils into which crop plants root and from which they obtain essential minerals and water contain huge arrays of microbes. Many have highly beneficial effects on crop growth and productivity, others are pathogens causing diseases and losses to yield and quality, a few microbes offer protection from these pathogenic forms and others have little or no effect. These intimate and often complex inter-relationships are being explored with increasing success providing exciting opportunities for increasing crop yields and quality in sustainable harmony with the populations of beneficial soil microbes and to the detriment of pathogens. This book explores current knowledge for each of these aspects of soil microbiology and indicates where future progress is most likely to aid in increasing crop productivity by means which are environmentally benign and beneficial.

The University and its Disciplines
The University and its Disciplines

Author: Carolin Kreber

Publisher: Routledge

Published: 2010-07-15

Total Pages: 376

ISBN-13: 113589034X

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University teaching and learning take place within ever more specialized disciplinary settings, each characterized by its unique traditions, concepts, practices and procedures. It is now widely recognized that support for teaching and learning needs to take this discipline-specificity into account. However, in a world characterized by rapid change, complexity and uncertainty, problems do not present themselves as distinct subjects but increasingly within trans-disciplinary contexts calling for graduate outcomes that go beyond specialized knowledge and skills. This ground-breaking book highlights the important interplay between context-specific and context-transcendent aspects of teaching, learning and assessment. It explores critical questions, such as: What are the ‘ways of thinking and practicing’ characteristic of particular disciplines? How can students be supported in becoming participants of particular disciplinary discourse communities? Can the diversity in teaching, learning and assessment practices that we observe across departments be attributed exclusively to disciplinary structure? To what extent do the disciplines prepare students for the complexities and uncertainties that characterize their later professional, civic and personal lives? Written for university teachers, educational developers as well as new and experienced researchers of Higher Education, this highly-anticipated first edition offers innovative perspectives from leading Canadian, US and UK scholars on how academic learning within particular disciplines can help students acquire the skills, abilities and dispositions they need to succeed academically and also post graduation. Carolin Kreber is Professor of Teaching and Learning in Higher Education and the Director of the Centre for Teaching, Learning and Assessment at the University of Edinburgh

Non-motor Parkinson's Disease
Non-motor Parkinson's Disease

Author: Néstor Gálvez-Jiménez

Publisher: Cambridge University Press

Published: 2022-03-10

Total Pages: 271

ISBN-13: 1316510654

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A comprehensive and practical manual describing the manifestations, pathophysiology and treatments for non-motor Parkinson's Disease. Topics covered in depth include autonomic and sexual dysfunction, mood disorders, sleep disturbances and drug-induced non-motor symptoms.

Carrion Ecology, Evolution, and Their Applications
Carrion Ecology, Evolution, and Their Applications

Author: M. Eric Benbow

Publisher: CRC Press

Published: 2015-08-18

Total Pages: 596

ISBN-13: 1466575476

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Shortlisted for the 2018 TWS Wildlife Publication Awards in the edited book categoryDecomposition and recycling of vertebrate remains have been understudied, hampered largely due to these processes being aesthetically challenging (e.g., smell and sight). Technological innovations have provided the means to explore new and historically understo

Active Food Packaging
Active Food Packaging

Author: M.L. Rooney

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 272

ISBN-13: 1461521750

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Food packaging materials have traditionally been chosen to avoid unwanted interactions with the food. During the past two decades a wide variety of packaging materials have been devised or developed to interact with the food. These packaging materials, which are designed to perform some desired role other than to provide an inert barrier to outside influences, are termed 'active packaging'. The benefits of active packaging are based on both chemical and physical effects. Active packaging concepts have often been presented to the food industry with few supporting results of background research. This manner of introduction has led to substantial uncertainty by potential users because claims have sometimes been based on extrapolation from what little proven information is available. The forms of active packaging have been chosen to respond to various food properties which are often unrelated to one another. For instance many packaging requirements for post harvest horticultural produce are quite different from those for most processed foods. The object of this book is to introduce and consolidate information upon which active packaging concepts are based. Scientists, technologists, students and regulators will find here the basis of those active packaging materials, which are either commercial or proposed. The book should assist the inquirer to understand how other concepts might be applied or where they should be rejected.

Neurocounseling
Neurocounseling

Author: Thomas A. Field

Publisher: John Wiley & Sons

Published: 2017-02-07

Total Pages: 295

ISBN-13: 1119375568

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This text presents current, accessible information on enhancing the counseling process using a brain-based paradigm. Leading experts provide guidelines and insights for becoming a skillful neuroscience-informed counselor, making direct connections between the material covered and clinical practice. In this much-needed resource—the first to address neurocounseling concepts across the counseling curriculum—chapters cover each of the eight common core areas in the 2016 CACREP Standards in addition to several specialty areas of the Standards. Detailed case studies, questions for reflection, quiz questions, and a glossary facilitate classroom use. *Requests for digital versions from ACA can be found on www.wiley.com. *To purchase print copies, please visit the ACA website *Reproduction requests for material from books published by ACA should be directed to [email protected]