Recent advances in neonatal hematology, largely made by the authors of these chapters, are likely to generate wide spread and long-term improvements in outcomes, as well as reductions in costs of care. Publication of these advances in a single volume will facilitate dissemination of these techniques and practices. The advances include neuroprotection from erythropoietic stimulators, improved guidelines for platelet transfusions, evidence-based guidelines for FFP administration, improved diagnostic methods for genetic causes of severe neonatal jaundice, more accurate definitions of hematological perturbations in necrotizing enterocolitis and sepsis, and reduction in transfusions and in IVH rates by cord milking/delayed clamping.
Preterm neonates remain at increased risk for adverse bilirubin-related outcomes, including acute bilirubin encephalopathy relative to term infants. Yet, most vulnerable neonates are likely to benefit from the potent anti-oxidant properties of bilirubin. Evidence-based guidelines for the management of hyperbilirubinemia in preterm infants, however, are lacking. High concentrations of unconjugated bilirubin can cause permanent neurologic damage in infants, evident through magnetic resonance imaging of chronic bilirubin encephalopathy or kernicterus. There is a growing concern that exposures to even moderate concentrations of bilirubin may lead to subtle but permanent neurodevelopmental impairment referred to as bilirubin-induced neurologic dysfunction. Our current use of phototherapy to decrease bilirubin loads and its potential photo-oxidant properties is a biological conundrum that has been questioned in the use of phototherapy for very low birth weight neonates. In this issue of Clinics in Perinatology, we provide updates on the current understanding of the biology, mechanisms of increasing bilirubin load due to hemolysis, decreased bilirubin binding capacity and glucose-6-phosphate dehydrogenase deficiency, as well as clinical strategies to operationalize the thresholds for hyperbilirubinemia interventions in preterm infants.
Bronchopulmonary dysplasia (BPD) as a chronic lung disease affecting preterm infants has been recognized for more than 45 years. However, little progress has been made in the prevention and treatment of the disease. BPD continues to be a major morbidity affecting preterm infants. Studies in pre-adolescent children demonstrate that the abnormal lung function from BPD persists well into childhood. Infants with BPD also have an increased risk for adverse neurodevelopmental outcome. Thus BPD imposes a significant burden of adverse health outcomes in preterm infants. The major risk factors for BPD are prematurity, mechanical ventilation, exposure to noxious insults such as oxygen, infections. New research data both in basic science and clinical studies have shed light on the pathogenesis, and possible new treatment or management strategies for the future. In the proposed issue of the Clinics in Perinatology, we would like to comprehensively cover BPD both from a basic science and clinical perspective. Our attempt is to balance new information along with classic topics. The proposed authors for the issue are recognized experts in the topic area/s. We hope that the issue will be of interest to a broad array of readership.
Blood transfusions are an important part of hematologic care. This issue of Hematology/Oncology Clinics will focus on transfusion medicine and will include articles on: RBC Transfusions: Conclusions from Clinical Trials and the Establishment of Evidence-based Guidelines for Adults, Platelet Transfusions: Conclusions from Clinical Trials and the Establishment of Evidence- and/or Experience-based Guidelines for Adults, Use and Overuse of Plasma Products: Establishment of Evidence- and/or Experience-based Guidelines for Plasma Transfusion in Adults, Stem Cell Mobilization/Collection: Coordination Between Hem/Onc, Transplant, and Transfusion Services, Management of Patients with Sickle Cell Disease Using Transfusion Therapy: Guidelines and Complications, and many more exciting articles.
Written for neonatal and pediatric nurse practitioner students, Fetal and Neonatal Physiology for the Advanced Practice Nurse explores the developmental physiology of premature and term infants and presents common diseases that affect this specialized population. This unique text offers an innovative and engaging approach to learning normal and abnormal physiology to prepare students for their roles as resourceful and informed problem-solvers, caregivers, and health promoters. Part One introduces core concepts including fetal origins of disease, genetic inheritance patterns, and placental physiology. Part Two investigates each major human body system. Finally, Part Three offers an exploration into the transition to extrauterine life and common challenges for perinatal and neonatal clinicians. With a multitude of student learning resources and tools, Fetal and Neonatal Physiology for the Advanced Practice Nurse promotes contemplative thinking, understanding, and retention. Every chapter includes learning objectives for guidance, advice from the authors, and a mind map to visualize difficult concepts. Written by junior and senior nurses and physicians, this text embodies the interprofessional approach associated with optimal outcomes. Chapter podcasts and discussion questions are included with the text to actively integrate written content and engage students using multisensory teaching methods. Key Features Presents a concise, visual and interactive presentation of a challenging subject Designed specifically to accommodate a semester-long course Contains numerous illustrations depicting fetal development and physiology of the different body systems Each chapter contains reflective questions and other interactive learning resources Incorporates genetics and pathophysiologic correlations Meets the nationally-recognized accreditation requirements for APN physiology coursework
Neonatal Clinical Pharmacology and Therapeutics covers the significant advances in clinical pharmacology and the principles of neonatal therapeutics. This book is composed of 20 chapters that tackle various neonatal diseases and their corresponding therapeutic options. The opening chapters review the pharmacological principles and kinetics, placental drug transfer, and drug therapy in pregnancy. The next chapters consider the other aspects of clinical pharmacology, including tocolytics, oxytocin, maternal drug use, neonatal withdrawal, prophylaxis, and the effect of material analgesia and anesthetics on newborn. Considerable chapters are devoted to the treatment options of neonatal diseases, including apnea, pulmonary and systemic disorders, cardiac diseases, jaundice, hypoglycemia, and nutrient deficiencies. The remaining chapters discuss other therapeutic options, such as blood cell component therapy, the use of analgesia and muscle relaxants, and parenteral nutrition. This book is intended primarily for all doctors who care for newborn babies and clinical pharmacologists.
This issue will provide a current update on diagnosis, treatment, and management of children with being hematological disorders. Dr. Callaghan has put together a comprehensive issue with clinical reviews written by top experts in the field. Articles are devoted to the following topics: Hemophilia; Sickle cell acute chest; Sickle cell drugs; Sickle cell gene therapy; Sickle cell menses and pain; Pediatric DVT; Atypical HUS; von Willebrand Disease; Female bleeding; Functional platelet disorders; Hemolytic anemia; Advocacy in hematology; ITP; and Acquired aplastic anemia. Readers will come away with the current clinical information they need to improve clinical outcomes.
Written and edited by renowned experts in pediatric anesthesia, Smith's Anesthesia for Infants and Children provides clear, concise guidance on effective perioperative care for any type of pediatric surgery. The 10th Edition contains significantly revised content throughout, bringing you fully up to date with recent advances in clinical and basic science that have led to changes in today's clinical practice. - Offers comprehensive coverage of physiology, pharmacology, and clinical anesthetic management of infants and children of all ages. - Contains new chapters on Airway Physiology and Development, Normal and Difficult Airway Management, Ultrasound, Acute Pain Management, Chronic Pain Management, Palliative Pain Management, Infectious Diseases, and Education; plus extensively revised content on cardiovascular physiology; induction, maintenance, and recovery; organ transplantation, and more. - Features more than 100 video demonstrations, including regional anesthesia videos, echocardiograms of congenital heart lesions, anatomic dissections of various congenital heart specimens with audio explanations, various pediatric surgical operative procedures, airway management, and much more. - Provides outstanding visual guidance throughout, including full-color photographs, drawings, graphs and charts, and radiographic images. - Includes quick-reference appendices online: drug dosages, growth curves, normal values for pulmonary function tests, and a listing of common and uncommon syndromes. - Provides an interactive question bank online for review and self-assessment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Completely revised, the second edition of Key Topics in Neonatology provides a practical, systematic reference for all the major topics in neonatal medicine. Practical and easy to use, the book retains the same well-received format as the first edition, updates subject matter where significant recent developments have taken place, and widens the scope of the text by adding entirely new coverage. Distilling this large body of information into compact yet clear topics, the authors provide succinct reviews of issues that are often skimmed over in similar sized texts. This is the resource you will want on hand to solve the complex issues you face on a daily basis. New topics include: Abdominal Wall Defects Breast Feeding Cerebral Palsy Hearing Screening Hepatitis C Metabolic Acidosis Outcomes of Neonatal Intensive Care Updated topics include: Childbirth Complications and Fetal Outcome Chromosomal Abnormalities Chronic Lung Disease Complications of Mechanical Ventilation Congenital Malformations and Birth Defects Death of a Baby Extreme Prematurity Hepatitis B HIV/AIDS Immunisation Infants of Diabetic Mothers Jaundice Liver Disorders Maternal Drug Abuse Neonatal Screening for Inherited Disease Sedation and Analgesia on the Neonatal Intensive Care Unit Seizures Transfusion of Blood and Blood Products Transport of Sick Neonates, and more
Praise for the Fifth Edition: “This book provides a complete look at neonatal healthcare delivery...[It] includes discussions of contemporary topics of interest, such as informatics, genetics, global health, and family-centered care, which are vital to providers caring for neonates today. The case studies and evidence-based practice dialogues provide great opportunities for further reflection. The book is useful to a wide audience in nursing, including undergraduate and graduate nursing students, practicing neonatal and pediatric nurses, and advanced practice nurses who care for neonates." Score: 92, 4 Stars--Doody's Medical Reviews The sixth edition of this acclaimed neonatal nursing text is completely updated to encompass the most current research findings and strategies for providing cost-effective and evidence-based care. It continues to address neonatal care from a physiologic and pathophysiologic perspective, with a major emphasis on nursing management at the bedside and advanced practice level. It examines each neonatal body system and describes evidence-based interventions that assist in understanding the ‘why’ behind various clinical presentations. Integrative management is threaded throughout the text along with extensive research findings to support practice strategies and rationales for sound clinical decision-making. Case studies, evidence-based practice boxes, QSEN competencies, and online resources help to amplify and reinforce content. New to the Sixth Edition: New technologies including neonatal health care simulation Trauma-Informed Care Substantial revisions to the Neonatal Resuscitation Program Updates in Continuous Quality Improvement Emphasis on neuroprotective factors Emerging global trends Genomics and its relationship to precision health prevention of diseases Maternal-Fetal Units Neonatal Abstinence Syndrome and maternal drug use Leadership and cost management of the NICU Updates on neonatal care protocols and procedures, new treatments, and new trends in family-centered integrative developmental care New palliative care protocols Video clips regarding parental caregiving Parent perspectives on care Podcasts from experts in the field Highlighted callouts for Emergency Alert, Quality and Safety Issues, and Family Concerns Key Features: Complete physiologic and embryologic foundation of each neonatal body system The relevance of various diagnostic tests Integrates quality and safety as per QSEN competencies Case studies, evidence-based practice boxes, parent handouts, and online resources Authored by internationally reputed “mother” of neonatal nursing Parent Voices provide new perspective on neonatal care
