Chemistry and Biochemistry of B12
Chemistry and Biochemistry of B12

Author: Ruma Banerjee

Publisher: John Wiley & Sons

Published: 1999-11-03

Total Pages: 960

ISBN-13: 9780471253907

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A Definitive New Reference for the Latest Advances in B_12 Chemistry and Biochemistry Over the past decade, the field of B_12 research has been revolutionized by such major breakthroughs as the unraveling of the entire biosynthetic pathway for this important vitamin. This comprehensive compendium surveys the wealth of information that has accumulated, covering in one volume virtually all aspects of the field-from physical and inorganic chemistry to enzymology, microbiology, medicine, and diagnostic and therapeutic applications. Edited by Dr. Ruma Banerjee, a highly respected and active member of the B_12 community, this work provides B_12 researchers with a dependable and up-to-date reference on the subject. Leading authorities from five continents explore such new areas as the structural biology of B_12-dependent enzymes, free-radical-mediated reaction mechanisms, biosynthesis, and much more. The role of B_12 in nutrition and disease, and B_12 transport, are also thoroughly examined. Complete with color illustrations and extensive references, Chemistry and Biochemistry of B_12 is a one-of-a-kind resource for biochemists, biophysicists, spectroscopists, microbiologists, molecular biologists, and anyone with an interest in "nature's most beautiful cofactor."

Industrial Biotechnology of Vitamins, Biopigments, and Antioxidants
Industrial Biotechnology of Vitamins, Biopigments, and Antioxidants

Author: Erick J. Vandamme

Publisher: John Wiley & Sons

Published: 2016-04-25

Total Pages: 580

ISBN-13: 3527337342

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Vitamins are a group of physiologically very important, chemically quite complex organic compounds, that are essential for humans and animals. Some vitamins and other growth factors behave as antioxidants, while some can be considered as biopigments. As their chemical synthesis is laborious, their biotechnology-based synthesis and production via microbial fermentation has gained substantial interest within the last decades. Recent progress in microbial genetics and in metabolic engineering and implementation of innovative bioprocess technology has led to a biotechnology-based industrial production of many vitamins and related compounds. Divided into three sections, this volume covers: 1. water-soluble vitamins 2. fat-soluble vitamin compounds and 3. other growth factors, biopigments, and antioxidants. They are all reviewed systematically: from natural occurrence and assays, via biosynthesis, strain development, to industrially-employed biotechnological syntheses and applications.

Laboratory Assessment of Vitamin Status
Laboratory Assessment of Vitamin Status

Author: Dominic J. Harrington

Publisher: Academic Press

Published: 2018-11-28

Total Pages: 342

ISBN-13: 0128130512

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Laboratory Assessment of Vitamin Status provides a comprehensive understanding of the limitations of commonly used approaches used for the evaluation of vitamin status, reducing harm in the general health setting. It outlines the application of 'Best Practice' approaches to the evaluation of vitamin status, giving physicians and other healthcare professionals the opportunity to make evidence-based interventions. Nearly every metabolic and developmental pathway in the human body has a dependency on at least one micronutrient. Currently, the clinical utility of approaches taken by laboratories for the assessment of vitamin status is generally poorly understood, missing the opportunity to diagnosis vitamin deficiencies. This essential reference gives clinical and biomedical scientists an understanding of the limitations of commonly used approaches to the evaluation of vitamin status in the general health setting through change in practice. Nutritionists and dietitians gain an understanding of more sophisticated markers of vitamin status. - Describes specialist assays in sufficient detail to enable laboratories to replicate what is being performed by expert groups - Provides detailed information that supports laboratories in the setting up of methods for the evaluation of vitamin status - Informs laboratories looking for third party providers of specialist investigations - Provides an essential overview of reference ranges for each vitamin

Vitamin C
Vitamin C

Author: M B Davies

Publisher: Royal Society of Chemistry

Published: 2007-10-31

Total Pages: 174

ISBN-13: 1847552307

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Vitamin C is the first book to cover the history, chemistry, biochemistry, and medical importance of vitamin C and is the first to provide an in-depth, interdisciplinary study of this essential and fascinating compound. The book provides a comprehensive and systematic account of the vitamin C story, fully surveying the history of scurvy and how its cure led to the suggestion, discovery, and isolation of the vitamin, later named L-ascorbic acid. It describes in detail the vitamin's structure determination, synthesis and manufacture, and its oxidation products, derivatives and related compounds. Its key biochemical roles are fully categorized and explained, and the medical importance of the vitamin, including the recent use of so-called megadoses, is thoroughly discussed. Vitamin C will be of interest to a very wide readership and will provide useful background information and inspiration for students at various levels. It will also be relevant to the interested chemist or lay person, as well as those carrying out research in this area.

Vitamin B12
Vitamin B12

Author: Rima Obeid

Publisher: CRC Press

Published: 2017-07-12

Total Pages: 378

ISBN-13: 1351645854

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Cobalamin (vitamin B12) was discovered in the first half of the 20th century. Vast amount of information on the role of the vitamins in human health and disease became available. Cobalamin science was, however, based on theoretical concepts that have been accepted without further proof of facts and hypotheses. Recently, the breath-taking pace of development in research technologies has changed our understanding for the role of nutrients and the complex interaction between diet, environment and diseases. Conditions like aging, diet and drugs increase the risk of developing cobalamin deficiency, probably because of diminished ability to liberate, absorb or distribute the food-derived vitamin. From a basic science point of view, understanding of the transport and function of the vitamin, may pave the road for using this system for drug delivery. This book represents up-to-date literature on the discoveries and developments in the field of cobalamin. It includes multifaceted aspects of the vitamin in health and disease conditions. The book has been written by leading scientists who have significant contributions in this field and represents therefore, a timely unique encyclopaedia on cobalamin.

B Vitamins and Folate
B Vitamins and Folate

Author: Victor R. Preedy

Publisher: Royal Society of Chemistry

Published: 2013

Total Pages: 890

ISBN-13: 1849733694

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Written by an expert team, this research compilation provides a fascinating insight into the scientific knowledge around these compounds for health and nutritional scientists.

The Chemical Biology of Human Vitamins
The Chemical Biology of Human Vitamins

Author: Christopher Walsh

Publisher: Royal Society of Chemistry

Published: 2019

Total Pages: 462

ISBN-13: 1788014642

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This textbook provides a thorough chemocentric view on the key small molecules of life, the human vitamins and their active coenzyme forms.

Metal Ions in Biochemistry
Metal Ions in Biochemistry

Author: Pabitra Krishna Bhattacharya

Publisher: CRC Press

Published: 2020-12-13

Total Pages: 428

ISBN-13: 1000292665

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The second edition of Metal Ions in Biochemistry deals with the multidisciplinary subject of bio-inorganic chemistry, encompassing the disciplines of inorganic chemistry, biochemistry and medicine. The book deals with the role of metal ions in biochemistry, emphasising that biochemistry is mainly the chemistry of metal-biochemical complexes. Hence, the book starts with the structures of biochemicals and the identification of their metal binding sites. Thermodynamic and kinetic properties of the complexes are explained from the point of view of the nature of metal-ligand bonds. Various catalytic and structural roles of metal ions in biochemicals are discussed in detail. Features The role of Na+ and K+ in brain chemistry. The role of zinc insulin in glucose metabolism and its enhancement by vanadium and chromium compounds. Discussion of the role of zinc signals, zinc fingers and cascade effect in biochemistry. Haemoglobin synthesis and the role of vitamin B12 in it. The role of lanthanides in biochemical systems. A detailed discussion of the role of non-metals in biochemistry, a topic missing in most of the books on bio-inorganic chemistry. The study of bio-inorganic chemistry makes biochemists rethink the mechanistic pathways of biochemical reactions mediated by metal ions. There is a realisation of the role of metal complexes and inorganic ions as therapeutics such as iron in leukaemia, thalassemia and sickle cell anaemia, iodine in hypothyroidism and zinc, vanadium and chromium in glucose metabolism. The most recent realisation is of the use of zinc in the prevention and treatment of COVID-19.

Radical SAM Enzymes
Radical SAM Enzymes

Author:

Publisher: Academic Press

Published: 2018-08-09

Total Pages: 0

ISBN-13: 9780128127940

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Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more.