Charge migration through DNA has been the focus of considerable interest in recent years. This book presents contributions from an international team of researchers active in this field. It contains a wide range of topics that includes the mathematical background of the quantum processes involved, the role of charge transfer in DNA radiation damage, a new approach to DNA sequencing, DNA photonics, and many others.
The past few years have witnessed intense research in this fascinating field as well as many controversial discussions. Now the time is ripe for a comprehensive book covering not only theoretical aspects, but also such mechanistic topics as principles and mechanisms of photoinduced charge injection, transport and trapping in DNA, sequence-dependent DNA dynamics, spectroscopic investigations of hole transport and much more. From the contents: * Principles and Mechanisms of Photoinduced Charge Injection, Transport and Trapping in DNA * Sequence-Dependent DNA Dynamics: The Regulator of DNA-Mediated Charge Transport * Excess Electron Transfer in DNA Probed with Flavin and Thymine Dimer Modified Oligonucleotides * Dynamics of Photoinitiated Hole and Electron Injection in Duplex DNA * Spectroscopic Investigation of Oxidative Hole Transfer via Adenine Hopping in DNA * Chemical Probing of Reductive Electron Transfer in DNA * Chemical Approach for Modulating Hole Transport in DNA * Spectroscopic Investigation of Charge Transfer in DNA * Spectroscopic Probing of Ultrafast Structural Relaxation and Electron Transfer Dynamics in DNA Edited by Hans-Achim Wagenknecht, and written by renowned international authors, this book provides an excellent overview with high quality contributions, making it a "must-have" for everyone working in the field.
This text details contemporary electroanalytical strategies of biomolecules and electrical phenomena in biological systems. It presents developments in sequence-specific DNA detection for more efficient medical diagnosis of genetic and infectious diseases and microbial and viral pathogens.
The lipid bilayer is central to life, as all living organisms possess a lipid bilayer structure, thereby underlying the lipid bilayer principle of biomembranes. The lipid bilayer principle and its applications are the main theme of this new book series.This new series on bilayer lipid membranes (BLMs and liposomes) include invited chapters on a broad range of topics, from theoretical investigations, specific studies, experimental methods, to practical applications. Written for newcomers, experienced scientists, and those who are not familiar with these specific research areas, the Series covers all aspects of lipid bilayer investigations, both fundamental and applied.* Covers a broad range of topics ranging from theoretical research, specific studies, experimental methods, to practical applications* Authoritative timely reviews by experts in this field* Indispensable source of information for new scientists
Charged Particle and Photon Interactions with Matter offers in-depth perspectives on phenomena of ionization and excitation induced by charged particle and photon interactions with matter in vivo and in vitro. This reference probes concepts not only in radiation and photochemistry, but also in radiation physics, radiation biochemistry, and radiatio
This book is a collection of original research and survey articles on mathematical inequalities and their numerous applications in diverse areas of mathematics and engineering. It includes chapters on convexity and related concepts; inequalities for mean values, sums, functions, operators, functionals, integrals and their applications in various branches of mathematics and related sciences; fractional integral inequalities; and weighted type integral inequalities. It also presents their wide applications in biomathematics, boundary value problems, mechanics, queuing models, scattering, and geomechanics in a concise, but easily understandable way that makes the further ramifications and future directions clear. The broad scope and high quality of the contributions make this book highly attractive for graduates, postgraduates and researchers. All the contributing authors are leading international academics, scientists, researchers and scholars.
The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.
This unique volume presents the scientific achievements of outstanding scientists from different countries working in diverse areas of Condensed Matter Physics. Drawn from the 32nd International Workshop on Condensed Matter Theories held in Loughborough in August 2008, these 46 papers, while centered on the concepts and techniques of theoretical condensed matter physics, also address broad issues of common concern for all physicists. It is particularly relevant to theorists who apply advanced many-particle methods in other areas of physics.The primary topics covered in the paper contributions include: statistical mechanics, nonlinear dynamics, quantum Fermi and Bose liquids, boson condensates, strongly correlated electron systems, superconductivity and phase transitions. Among the specific questions addressed and discussed are modern theories of graphene, Quantum Hall Effect, models of social dynamics, which are based on the example of Obama-McCain election, extraordinary magnetoresistance, supercooled atomic gases, transitions between various magnetic states in different systems made from magnetic nanoparticles, order-disorder-order phase transitions in spin frustrated systems, embolic stroke and semifluxon dynamics in extended Josephson junctions. The book provides the latest updated information on modern Condensed Matter Theories and the methods used. The many recent developments in the field such as the discovery of graphene or of new phenomena in supercooled gases or of an extraordinary magnetoresistance augur well for this timely publication. The main value of the book lies in the diversity of topics being covered comprehensively, which puts the book in a primary position in the modern market.
