The world is under constant threat of a virus evolving into a global plague. To this point, there is no direct defense against a widespread viral infection. DNA Vaccines: Design of a Gene to Eradicate HIV offers an innovative and new strategy to combat deadly viral infections. Presented is the discovery of a unique identifier for HIV. Analysis of the transcription and translation mechanisms utilized by cells leads to exploring the function of nuclear transcription factor proteins as intracellular hunter-killer molecules aimed specifically at viral genomes. Utilizing amino acid-to-nucleotide binding characteristics, taking into account Watson-Crick binding, Hoogsteen grove binding, and Vander Waals forces, modifications to existing transcription factors binding sites are undertaken. Transcription factors are altered to specifically target the unique identifier of pathogenic viruses. Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cells cytoplasm as RNA. This text describes the design of an intracellular courier gene technology to make cells defensible against HIV and other lethal pathogenic viral threats.
The luminous aether, a concept known for hundreds of years, is the fine essence of the universe. Over the last 130 years, mainstream science abandoned the knowledge such an aether existed. Yet, reawakening the principles of a luminous aether as the fabric of space--both within our being and surrounding us, reaching out in every direction to the very edges of the universe-- explains many unsolved mysteries. The luminous aether is a vast three-dimensional ocean of the tiniest and most elemental particles called quadsitrons. From the fusion of quadsitrons and energy, all else in the universe is constructed. The dynamics of quadsitrons interacting with energy accounts for and connects all the micro and macrophenomena that fill our lives, such as gravity, light, electrons, atoms, molecules, and magnetism. It is essential we understand and grasp the principles of this wondrous quadsitron-energy connectivity in order to advance our technology forward to interstellar travel.
Advances in medicine have brought us the stethoscope, artificial kidneys, and computerized health records. They have also changed the doctor-patient relationship. This book explores how the technologies of medicine are created and how we respond to the problems and successes of their use. Stanley Joel Reiser, MD, walks us through the ways medical innovations exert their influence by discussing a number of selected technologies, including the X-ray, ultrasound, and respirator. Reiser creates a new understanding of thinking about how health care is practiced in the United States and thereby suggests new methods to effectively meet the challenges of living with technological medicine. As healthcare reform continues to be an intensely debated topic in America, Technological Medicine shows us the pros and cons of applying technological solutions health and illness.
The world is on fire, threatened by a global pandemic brought on by COVID-19. This virulent viral pathogen has rapidly infected every continent across the globe and has spread misery and death in its wake. COVID-19 is very efficient, carrying in its genetic code the instructions to construct its own personal replication machinery. This virus is very effective at copying itself, but does so with a relatively high rate of mutation to the genetic code. Given Coronavirus exhibits a frequent rate of alteration to its state, resulting in an elusive adversary, which makes treating with traditional vaccines an ongoing challenge. Fighting back with novel mRNA therapies, which can be rapidly redesigned, may offer an effective broad-spectrum therapeutic armamentarium to combat Coronavirus. Modification of the native human CD8 cell surface receptor to alert the immune system to the possible presence of the COVID-19, can result in early development of antibodies to target the pathogen. But taking the fight directly to the virus, to stop the infection in an afflicted person, is the next necessary technologic leap in pharmaceutical medicine. Redesigning native human transcription factors to create a hunter-killer protein to neutralize the COVID-19 genome is the next critical innovation necessary to eradicate viral pandemics. Cultivating a cure to counteract viral infections such as Coronavirus is now more essential than ever. Ebola, a devastatingly hostile viral infection, sits lurking, in wait. At the point Ebola evolves into an airborne viral entity, the consequences of such a noxious global pandemic will be horrific. The time is now, to secure versatile and effective vaccines and devise an effective cure to stop rampant viral infections, such as Coronavirus and Ebola.
The world is under constant threat of a virus evolving into a global plague.To this point, there is no direct defense against a widespread viral infection. Fourth Generation Biologics: Molecular Virus Killers offers an innovative, new strategy to combat deadly viral infections. Presented is the discovery of unique identifiers for the viral scourges: HIV, Herpes Simplex, the Shingles virus, the Smallpox virus and the newly emerging threats of Ebola virus and the Chikungunya virus. Analysis of the transcription and translation mechanisms utilized by cells leads to exploring the function of nuclear signaling proteins as intracellular hunter-killer molecules aimed specifically at viral genomes. Utilizing amino acid-to-nucleotide binding characteristics, taking into account Watson-Crick binding, Hoogsteen grove binding, and Vander Waals forces, modifications to existing transcription factors binding sites is undertaken. Transcription factors are altered to specifically target the unique identifier of pathogenic viruses. Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cells cytoplasm as RNA. This emerging technology is then extrapolated to explore activating therapeutic nuclear genes to treat challenging medical conditions including diabetes and osteoarthritis.
Current students of philosophy or armchair philosophers... Want the answer to the Primordial Existential Question: Why is there something rather than nothing? While history has produced no shortage of attempted answers, clearly none is the answer. Now comes the unique perspective of acosmism to provide a complete and plausible answer. After a lifetime of reflection, acosmist Sherman O'Brien offers this analysis of the issues and a thoughtful, reasoned answer to philosophy's most vexing question. The acosmic answer requires no faith whatsoever, either in supernatural or unexplained causes; in fact, it discourages it. Acosmism rejects both traditional religion and philosophically neglectful science. As a metaphysical system, it is based on an epistemological insight, with implications for immortality, determinism, ethics, and ultimate purpose. Reasoned wholly from the ground up, its conclusion is the very meaning of existence. The solution to the Omniscience Riddle becomes the key to understanding how the question is best stated and understood. This book represents one person's effort to make sense of what is true and what only seems to be so. Why is there something rather than nothing? What is your potential role in the entirety of experience? This foray into acosmism offers a path to the genuine understanding of both existence and reality. Note: the main text constitutes roughly two-thirds of the total pages, the remainder being mostly endnotes.
The Voice of Clinical ReasonHarrison’s Principles of Internal Medicine is the world's most trusted clinical medicine text—and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. Harrison's Principles of Internal Medicine stands as the benchmark for authoritative, practical information on patient care and the pathogenesis and clinical management of symptoms and signs and specific diseases. Written and edited by the world’s top experts in their respective fields, this landmark guide provides the comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Harrison’s is world-renowned as the most authoritative source for: • Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases • Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases • The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow • Updated clinical trial results and recommended guidelines • Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings • Coverage of both therapeutic approaches and specific treatment regimens • Practical clinical decision trees and algorithms • Organ-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, general and specific approaches to therapy Harrison’s remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world’s top experts are featured in the 21st edition: • Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer • Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries • More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes • More than a dozen atlases featuring curated collections of visual aspects of diagnosis and management • Complete, updated curation and synthesis of primary medical literature which incorporates current data from major studies and clinical trials • Clinical reasoning resources and helpful disease/presentation schemas • Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms
Today's medicine is strongly influenced by natural science, which focuses entirely on the material nature of reality. Molecular biology has become the foundation of modern medicine with the result that today's medical industry chases after technology to solve all its problems. In the process it is losing its own essence as it moves into fields increasingly alien to human nature as a whole. Nevertheless, many doctors are beginning to reexamine this exclusive worldview in favor of a more wholistic approach to healing. To this end, anthroposophical medicine encompasses a wide range of healing modalities, including orthodox, allopathic medicine. The Anthroposophical Approach to Medicine explores the body's relationship to soul and spirit on the basis of Rudolf Steiner's insights into the activities of the spiritual world. Edited by doctors Friedrich Husemann and Otto Wolff, this book invites us to an in-depth view of a true alternative to materialistically oriented medicine. Chapters include essays on childhood development and diseases; the disorders of old age; neuroses and psychological imbalances; pharmacology; healing plants; biochemistry and pathology; blood-work; and special diagnostic techniques. This first of a multi-volume series is an invaluable tool to all who want to extend the practice of medicine to include the whole human being.
The first edition of Understanding Global Health set a new information standard for this rapidly emerging subject. Written by a remarkable group of authors and contributors, this comprehensive, engagingly written text offers unmatched coverage of every important topic--from infectious disease to economics to war. Created with the non-specialist in mind, Understanding Global Health explores the current burden of disease in the world, how health is determined, and the problems faced by populations and health care workers around the world. The second edition has been thoroughly updated to include the most current information and timely topics. New chapters cover such topics as human trafficking, malaria and neglected tropical diseases, surgical issues in global health, and mental health. Every chapter includes Learning Objectives, Summary, Study Questions, and References and, in many instances, practical case examples. -- Provided by publisher.
To be the best doctor you can be, you need the best information. For more than 90 years, what is now called Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature. But Goldman-Cecil Medicine is not just a textbook. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier's full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information. - More than 400 chapters authored by a veritable "Who's Who" of modern medicine - A practical, templated organization with an emphasis on evidence-based references - Thousands of algorithms, figures, and tables that make its information readily accessible - Supplemented by over 1500 board-style questions and answers to help you prepare for certification and recertification examinations
